| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 2,590,303 | $68,876,157 | 2.32% | |
| 2. | Opaleye Management James A. Silverman | 292,590 | $7,779,968 | +15% | 1.03% |
| 3. | Woodline Partners Michael Rockefeller And Karl Kroeker | 262,933 | $6,991,388 | +26% | 0.03% |
| 4. | Stonepine Capital Timothy P. Lynch | 115,000 | $3,057,850 | -1% | 2.23% |
| 5. | HighVista Strategies Andre F. Perold | 112,917 | $3,002,463 | +7% | 0.77% |