| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 8,689,190 | $992,913,741 | +6% | 11.44% |
| 2. | Darwin Global Management Abhishek Trehan | 2,198,187 | $251,186,828 | +6% | 20.42% |
| 3. | Perceptive Advisors Joseph Edelman | 2,027,608 | $231,694,766 | +9% | 4.9% |
| 4. | Driehaus Capital Richard Driehaus | 1,721,296 | $196,692,494 | -12% | 1.68% |
| 5. | VenBio Select Advisor Kurt Von Emster | 1,175,000 | $134,267,250 | +105% | 1.95% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $16.00 | 937,500 | Large Shareholder | 5,156,553 | 2020-06-16 | Filing | |
| $16.00 | 12,500 | Director | 4,168,718 | 2020-06-16 | Filing | |
| $16.00 | 93,000 | Director | 2,222,967 | 2020-06-16 | Filing | |
| $16.00 | 250,000 | Director | 2,309,554 | 2020-06-16 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $87.05 | 132 | Officer | 109,491 | 2024-11-18 | Filing | |
| $86.49 | 1,757 | Officer | 109,623 | 2024-11-18 | Filing | |
| $85.60 | 6,111 | Officer | 111,380 | 2024-11-18 | Filing | |
| $105.50 | 105 | Officer, Director | 137,398 | 2024-11-07 | Filing | |
| $104.72 | 434 | Officer, Director | 137,503 | 2024-11-07 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 14,213,365 | $892,599,345 | 0.06% | |
| 2. | 8,575,847 | $538,563,192 | 0.01% | |
| 3. | 8,452,371 | $530,808,899 | 0.01% | |
| 4. | 6,981,376 | $438,407,264 | 0.26% | |
| 5. | 4,431,920 | $278,324,577 | 0.05% |
