| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Siren L.L.C. Raymond Debbane | 10,825,013 | $476,841,823 | +18% | 14.22% |
| 2. | Samsara BioCapital Srini Akkaraju And Michael Dybbs | 6,897,652 | $303,841,571 | +23% | 31.35% |
| 3. | Redmile Group Jeremy Green | 5,220,846 | $229,978,266 | +34% | 16.94% |
| 4. | Orbis Investment Management William B. Gray | 3,428,929 | $151,044,322 | +1035% | 0.63% |
| 5. | Paradigm Biocapital Advisors Senai Asefaw | 3,062,157 | $134,888,016 | +53% | 3.44% |