| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 6,084,412 | $340,605,384 | 4.53% | |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 6,084,249 | $340,596,259 | -5% | 3.63% |
| 3. | Perceptive Advisors Joseph Edelman | 3,680,473 | $206,032,879 | +4% | 5.67% |
| 4. | Polar Capital Brian Ashford-Russell And Tim Woolley | 1,500,000 | $83,970,000 | 0.46% | |
| 5. | Driehaus Capital Richard Driehaus | 1,290,975 | $72,268,780 | -1% | 0.59% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.17 | 10,000 | Officer, Director | 111,335 | 2021-03-30 | Filing | |
| $26.42 | 378,501 | Director | 3,074,893 | 2018-06-25 | Filing | |
| $17.00 | 100,000 | Large Shareholder | 2,696,392 | 2017-10-10 | Filing | |
| $17.00 | 100,000 | Large Shareholder, Director | 2,696,392 | 2017-10-10 | Filing | |
| $17.00 | 550,000 | Large Shareholder | 4,909,956 | 2017-10-10 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $62.00 | 7,030 | Officer | 19,209 | 2025-04-08 | Filing | |
| $60.00 | 6,700 | Officer | 26,239 | 2025-04-08 | Filing | |
| $59.00 | 600 | Officer | 32,939 | 2025-04-08 | Filing | |
| $58.36 | 6,430 | Officer | 33,539 | 2025-04-08 | Filing | |
| $61.54 | 9,312 | Officer | 22,620 | 2025-04-08 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 89,622 | $4,747,277 | 0.21% | |
| 2. | 85,719 | $4,540,522 | 0% | |
| 3. | 36,984 | $1,959,042 | 0.04% | |
| 4. | 22,192 | $1,175,510 | 0% | |
| 5. | 1,971 | $104,404 | 0.05% |
