| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 6,398,366 | $335,210,395 | +1% | 3.47% |
| 2. | RA Capital Management Peter Kolchinsky | 6,084,412 | $318,762,345 | 3.67% | |
| 3. | Perceptive Advisors Joseph Edelman | 3,560,214 | $186,519,611 | +4% | 3.94% |
| 4. | Polar Capital Brian Ashford-Russell And Tim Woolley | 1,500,000 | $78,585,000 | 0.37% | |
| 5. | Driehaus Capital Richard Driehaus | 1,299,490 | $68,080,281 | +10% | 0.58% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.17 | 10,000 | Officer, Director | 111,335 | 2021-03-30 | Filing | |
| $26.42 | 378,501 | Director | 3,074,893 | 2018-06-25 | Filing | |
| $17.00 | 100,000 | Large Shareholder | 2,696,392 | 2017-10-10 | Filing | |
| $17.00 | 100,000 | Large Shareholder, Director | 2,696,392 | 2017-10-10 | Filing | |
| $17.00 | 550,000 | Large Shareholder | 4,909,956 | 2017-10-10 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $68.43 | 200 | Officer | 972 | 2024-11-11 | Filing | |
| $67.56 | 11,070 | Officer | 1,172 | 2024-11-11 | Filing | |
| $66.95 | 17,540 | Officer | 12,242 | 2024-11-11 | Filing | |
| $65.68 | 38,051 | Officer | 29,782 | 2024-11-11 | Filing | |
| $67.83 | 700 | Officer | 0 | 2024-11-11 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 8,052,648 | $370,180,229 | 0.29% | |
| 2. | 6,351,750 | $291,989,948 | 0% | |
| 3. | 5,047,934 | $232,053,526 | 0.04% | |
| 4. | 3,226,938 | $148,342,339 | 0% | |
| 5. | 2,909,956 | $133,770,677 | 8.91% |
