| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 6,084,412 | $340,605,384 | 4.53% | |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 6,084,249 | $340,596,259 | -5% | 3.63% |
| 3. | Perceptive Advisors Joseph Edelman | 3,680,473 | $206,032,879 | +4% | 5.67% |
| 4. | Polar Capital Brian Ashford-Russell And Tim Woolley | 1,500,000 | $83,970,000 | 0.46% | |
| 5. | Driehaus Capital Richard Driehaus | 1,290,975 | $72,268,780 | -1% | 0.59% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.17 | 10,000 | Officer, Director | 111,335 | 2021-03-30 | Filing | |
| $26.42 | 378,501 | Director | 3,074,893 | 2018-06-25 | Filing | |
| $17.00 | 100,000 | Large Shareholder | 2,696,392 | 2017-10-10 | Filing | |
| $17.00 | 100,000 | Large Shareholder, Director | 2,696,392 | 2017-10-10 | Filing | |
| $17.00 | 550,000 | Large Shareholder | 4,909,956 | 2017-10-10 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $57.22 | 2,215 | Officer | 109,929 | 2025-02-19 | Filing | |
| $57.22 | 1,228 | Officer | 8,509 | 2025-02-19 | Filing | |
| $57.22 | 9,896 | Officer, Director | 201,281 | 2025-02-19 | Filing | |
| $57.22 | 2,035 | Officer | 5,858 | 2025-02-19 | Filing | |
| $57.22 | 635 | Officer | 2,070 | 2025-02-19 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 6,950,715 | $389,101,041 | 0% | |
| 2. | 6,571,190 | $367,855,216 | 0.28% | |
| 3. | 3,442,600 | $192,716,749 | 0% | |
| 4. | 2,909,956 | $162,899,337 | 9.19% | |
| 5. | 1,869,808 | $104,671,852 | 4.34% |
