| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Farallon Capital Thomas Steyer | 14,582,796 | $1,161,519,701 | -1% | 5.48% |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 9,455,357 | $753,119,185 | 4.41% | |
| 3. | Paradigm Biocapital Advisors Senai Asefaw | 6,644,403 | $529,226,699 | +7% | 13.51% |
| 4. | Biotechnology Value Fund / BVF Inc Mark Lampert | 3,356,782 | $267,367,686 | -16% | 9% |
| 5. | Deerfield Management James E. Flynn | 2,894,613 | $230,555,925 | -21% | 2.94% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $46.00 | 760,869 | $34,999,974.00 | 760,869 | 2024-12-05 | Filing | |
| $46.00 | 543,478 | $24,999,988.00 | 2,096,612 | 2024-12-05 | Filing | |
| $20.85 | 6,200 | $129,270.00 | 1,553,134 | 2023-03-10 | Filing | |
| $20.43 | 93,800 | $1,916,334.00 | 1,546,934 | 2023-03-10 | Filing | |
| $22.00 | 318,181 | $6,999,982.00 | 618,181 | 2023-03-07 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $115.60 | 908 | $104,964.80 | 46,976 | 2026-01-21 | Filing | |
| $102.90 | 1,700 | $174,930.00 | 141,053 | 2026-01-07 | Filing | |
| $101.79 | 20,204 | $2,056,621.73 | 142,753 | 2026-01-07 | Filing | |
| $100.02 | 53,096 | $5,310,470.77 | 162,957 | 2026-01-07 | Filing | |
| $98.00 | 10,000 | $980,000.00 | 108,065 | 2026-01-07 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 16,719,886 | $1,331,738,920 | 0.02% | |
| 2. | 12,303,502 | $980,035,989 | 0.44% | |
| 3. | 8,926,656 | $711,008,150 | 0.01% | |
| 4. | 8,587,981 | $684,032,699 | 0.03% | |
| 5. | 7,601,087 | $605,426,580 | 58.53% |
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