| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Paradigm Biocapital Advisors Senai Asefaw | 7,544,172 | $188,604,300 | +12% | 4.81% |
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 5,295,893 | $132,397,325 | 4.46% | |
| 3. | Siren L.L.C. Raymond Debbane | 3,300,700 | $82,517,500 | 2.46% | |
| 4. | Logos Capital Arsani William | 3,208,875 | $80,221,875 | 4.85% | |
| 5. | Cormorant Asset Management Bihua Chen | 2,750,000 | $68,750,000 | 3.18% |