| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | 70,000,000 | $180,707,800 | 2.31% | ||
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,495,290 | $118,112,957 | 3.98% | |
| 3. | Tang Capital Management Kevin C. Tang | 1,236,027 | $97,633,773 | 4.82% | |
| 4. | D E Shaw D. E. Shaw | 948,161 | $74,895,237 | +3% | 0.04% |
| 5. | Citadel Investment Group Ken Griffin | 840,220 | $66,368,978 | -20% | 0.01% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $68.48 | 131,425 | $8,999,984.00 | 459,010 | 2026-01-23 | Filing | |
| $43.93 | 21 | $922.61 | 168,672 | 2025-03-17 | Filing | |
| $44.11 | 528 | $23,291.40 | 168,651 | 2025-03-14 | Filing | |
| $43.77 | 963 | $42,155.13 | 168,123 | 2025-03-11 | Filing | |
| $43.37 | 577 | $25,023.34 | 167,160 | 2025-03-10 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $102.09 | 2,000 | $204,180.00 | 0 | 2026-02-13 | Filing | |
| $103.30 | 2,631 | $271,791.51 | 20,655 | 2026-02-02 | Filing | |
| $103.30 | 9,108 | $940,888.28 | 160,294 | 2026-02-02 | Filing | |
| $103.30 | 968 | $99,997.79 | 4,503 | 2026-02-02 | Filing | |
| $96.19 | 1,053 | $101,290.18 | 43,741 | 2026-01-26 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 6,795,121 | $536,746,608 | 14.42% | |
| 2. | 6,065,308 | $479,050,121 | 0.21% | |
| 3. | 3,645,286 | $287,941,139 | 0% | |
| 4. | 2,596,089 | $205,065,069 | 0% | |
| 5. | 2,143,992 | $169,353,928 | 0.01% |
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