| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 8,657,242 | $673,620,000 | +31% | 3.94% |
| 2. | VenBio Select Advisor Kurt Von Emster | 7,474,747 | $581,610,064 | +18% | 5.72% |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 5,502,710 | $428,165,865 | 14.41% | |
| 4. | Siren L.L.C. Raymond Debbane | 3,286,830 | $255,748,242 | -5% | 7.63% |
| 5. | Driehaus Capital Richard Driehaus | 1,069,238 | $83,197,409 | +14% | 0.57% |