| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 2,622,222 | $477,323,071 | +8% | 6.95% |
| 2. | Redmile Group Jeremy Green | 810,245 | $147,488,897 | -21% | 8.68% |
| 3. | Soleus Capital Guy Levy | 216,979 | $39,496,687 | +73% | 3.05% |
| 4. | Woodline Partners Michael Rockefeller And Karl Kroeker | 179,815 | $32,731,724 | -39% | 0.27% |
| 5. | Baker Bros. Advisors Julian Baker And Felix Baker | 169,934 | $30,933,086 | 0.32% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.00 | 25,000 | Large Shareholder, Officer, Director | 2,001,462 | 2018-10-18 | Filing | |
| $20.00 | 25,000 | Large Shareholder, Officer, Director | 2,036,462 | 2018-10-18 | Filing | |
| $12.45 | 1,018 | Large Shareholder, Officer, Director | 1,976,462 | 2018-06-06 | Filing | |
| $11.15 | 13,116 | Large Shareholder, Officer, Director | 1,975,444 | 2018-06-06 | Filing | |
| $10.75 | 10,866 | Large Shareholder, Officer, Director | 1,962,328 | 2018-06-05 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $171.63 | 640 | Large Shareholder, Officer, Director | 1,537,262 | 2024-12-13 | Filing | |
| $170.47 | 957 | Large Shareholder, Officer, Director | 1,537,902 | 2024-12-13 | Filing | |
| $169.65 | 911 | Large Shareholder, Officer, Director | 1,538,859 | 2024-12-13 | Filing | |
| $166.93 | 923 | Large Shareholder, Officer, Director | 1,539,770 | 2024-12-13 | Filing | |
| $165.82 | 1,977 | Large Shareholder, Officer, Director | 1,540,693 | 2024-12-13 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 2,435,774 | $302,182,123 | 0% | |
| 2. | 2,385,898 | $295,994,506 | 0.02% | |
| 3. | 1,809,547 | $224,492,402 | 0% | |
| 4. | 1,237,497 | $153,523,878 | 0% | |
| 5. | 988,460 | $122,628,348 | 6.55% |
