| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 1,706,469 | $290,099,730 | 13.16% | |
| 2. | Millennium Management Israel Englander | 1,202,711 | $204,460,870 | +347% | 0.09% |
| 3. | AQR Capital Management Cliff Asness | 877,267 | $149,135,332 | +26% | 0.08% |
| 4. | Renaissance Technologies Jim Simons | 836,774 | $142,251,580 | -10% | 0.22% |
| 5. | GMT Capital Thomas E. Claugus | 638,500 | $108,545,000 | -20% | 5.66% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $103.00 | 1,621 | $166,961.54 | 101,621 | 2025-05-12 | Filing | |
| $99.71 | 100 | $9,971.00 | 100,000 | 2025-05-09 | Filing | |
| $98.91 | 19,216 | $1,900,677.62 | 99,900 | 2025-05-09 | Filing | |
| $98.10 | 80,684 | $7,915,471.55 | 80,684 | 2025-05-09 | Filing | |
| $119.65 | 12,000 | $1,435,800.00 | 27,932 | 2024-03-01 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $169.51 | 2,238 | $379,365.62 | 19,508 | 2025-12-09 | Filing | |
| $171.20 | 4,500 | $770,405.40 | 7,012 | 2025-12-05 | Filing | |
| $171.11 | 160 | $27,377.60 | 7,012 | 2025-12-05 | Filing | |
| $177.27 | 38,126 | $6,758,672.27 | 393,332 | 2025-11-26 | Filing | |
| $179.79 | 507 | $91,154.70 | 431,458 | 2025-11-26 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 5,917,142 | $1,005,914,140 | 0.01% | |
| 2. | 5,451,241 | $926,710,907 | 0.02% | |
| 3. | 2,666,602 | $453,322,340 | 0.06% | |
| 4. | 2,623,303 | $445,964,615 | 0.09% | |
| 5. | 1,837,793 | $312,424,810 | 0.01% |