| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 1,706,469 | $190,117,711 | +69% | 6.5% |
| 2. | Polaris Capital Management Bernard Horn | 1,305,560 | $145,452,440 | -6% | 7.16% |
| 3. | Citadel Investment Group Ken Griffin | 1,053,521 | $117,372,775 | +172% | 0.02% |
| 4. | Renaissance Technologies Jim Simons | 1,049,974 | $116,977,603 | +3% | 0.17% |
| 5. | Vestal Point Capital Ryan Wilder | 900,000 | $100,269,000 | -40% | 7.6% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $119.65 | 12,000 | Officer | 27,932 | 2024-03-01 | Filing | |
| $112.32 | 11,482 | Director | 1,152,788 | 2020-05-27 | Filing | |
| $111.56 | 9,884 | Director | 1,141,306 | 2020-05-27 | Filing | |
| $110.52 | 8,391 | Director | 1,131,422 | 2020-05-27 | Filing | |
| $109.55 | 5,243 | Director | 1,123,031 | 2020-05-27 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $123.41 | 3,700 | Officer | 33,048 | 2024-11-08 | Filing | |
| $110.84 | 1,000 | Officer, Director | 428,976 | 2024-11-01 | Filing | |
| $108.30 | 1,410 | Officer | 14,531 | 2024-09-06 | Filing | |
| $108.83 | 163 | Officer | 6,596 | 2024-06-07 | Filing | |
| $109.65 | 5,000 | Officer | 36,629 | 2024-05-03 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 7,056,032 | $867,891,936 | 0.02% | |
| 2. | 6,363,748 | $782,741,004 | 0.01% | |
| 3. | 2,421,125 | $297,798,375 | 0.01% | |
| 4. | 1,397,284 | $171,865,938 | 0.01% | |
| 5. | 1,312,771 | $161,470,833 | 0.04% |
