| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Darwin Global Management Abhishek Trehan | 20,933,277 | $3,644,274,193 | +3% | 73.78% |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 6,592,746 | $1,147,401,514 | -2% | 6.72% |
| 3. | D E Shaw D. E. Shaw | 4,350,995 | $757,247,170 | -24% | 0.42% |
| 4. | Orbis Investment Management William B. Gray | 4,179,957 | $727,479,716 | +29% | 3.05% |
| 5. | Millennium Management Israel Englander | 1,311,654 | $228,280,262 | -44% | 0.1% |