| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 2,860,000 | $48,362,600 | 6.38% | |
| 2. | EcoR1 Capital Oleg Nodelman | 2,030,544 | $34,336,499 | 1.56% | |
| 3. | Nantahala Capital Management Wilmot B. Harkey And Daniel Mack | 1,175,951 | $19,885,331 | 0.66% | |
| 4. | Cannell Capital J. Carlo Cannell | 216,917 | $3,668,066 | -53% | 1.78% |
| 5. | Renaissance Technologies Jim Simons | 205,700 | $3,478,387 | -37% | 0.01% |