| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 14,555,555 | $364,034,431 | +35% | 3.58% |
| 2. | Adage Capital Management Phill Gross And Robert Atchinson | 11,281,741 | $282,156,342 | +13% | 0.43% |
| 3. | Farallon Capital Thomas Steyer | 5,377,068 | $134,480,471 | +25% | 0.63% |
| 4. | Siren L.L.C. Raymond Debbane | 4,027,517 | $100,728,200 | +25% | 3% |
| 5. | EcoR1 Capital Oleg Nodelman | 3,115,000 | $77,906,150 | +467% | 3.53% |