| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 7,880,094 | $382,026,957 | 17.33% | |
| 2. | Point72 Asset Management Steve Cohen | 1,932,890 | $93,706,507 | -15% | 0.1% |
| 3. | Tang Capital Management Kevin C. Tang | 1,332,087 | $64,579,578 | -1% | 3.19% |
| 4. | Millennium Management Israel Englander | 813,571 | $39,441,922 | -47% | 0.02% |
| 5. | Palo Alto Investors William Leland Edwards | 690,032 | $33,452,751 | +3% | 4.66% |