So I think you should — we feel pretty good about it. And that gives us the confidence to make a public comment about that.
Jonathan Chang: Got it. Thank you.
Operator: Thank you for your question. We are now taking the next question. Please stand by. The next question from Ziyi Chen from GS. Please go ahead. Your line is open.
Ziyi Chen: Thank you. Thank you for taking my questions. The first question is, if we’re looking at the commercial infrastructure, or with more drugs expected to be launched in 2023 and next year, including margetuximab, eGFR and more antibiotics. So the therapeutic category is becoming much bigger compared to what is now. Trying to understand a bit more about your plan in terms of commercialization team set up in order to achieve the sales efficiency and, of course, maintain the productivity when covering a variety of different therapeutic areas. And secondly, since you mentioned about, Optune, we’re looking forward to the data. But could you elaborate a little bit more about based on the LUNAR data and what you’re going to planning to communicate to in China and what could potentially be the pathway, and also timetable for the potential indication of in China. Thank you.
Jonathan Wang: Yes, thanks, Ziyi. And I’ll give your second question to Rafael. On your first question, as you know people who are familiar with Zai Lab story knows, we’ve been pretty thoughtful about curating a portfolio that’s clustered around specific areas that are very strategic for us. And within that, some of the — they’re all quite differentiated and some of the programs are quite large in terms of commercial potential. So potential blockbusters would be the likes of the based on data for LUNAR, the Tumor Treating Fields franchise, bemarituzumab, adagrasib as a pipeline program. I think that people are also under estimating under appreciating drugs like KarXT et cetera. So that’s point one. Point two is it’s actually a — if you look at a snapshot of a quarter, two quarter, three quarter, you will not see it.
But if you look at what we have in currently the NDA submissions, and you’ve already mentioned some of those, and you look at the programs that we have in pivotal stage right now. There’s also a lot of clustering effect going on. So for women’s cancer franchise that we’ve already built that with ZEJULA , but we have tipped back that Josh mentioned that these are pretty substantial operating leverage that kicks in, I believe that we have a slide on corporate debt that says, here’s a case study for ZEJULA, which is the first drug in women’s cancer franchise, you layer it back on top of that, and we’re sort of expecting commercial profitability kind of profit margins for that product to be in the 40% range, and you can build upon from there. And then you look at the long programs in just the near-term stuff.
And you’ve got in addition to of course, LUNAR, which benefits from of course, a specialized sales force for Tumor Treating Fields, and often anyways, the lung itself would have — a LUNAR, the KRAZATI, we got the ROS1, and probably missing one or two more. And so we think that we have a lot of just a great opportunity here to drive productivity as we scale kind of revenue, pretty much at the same time. Again, you will not see it in like a quarter view, two quarter view from within a 1 to 2-year timeframe, you should really begin to see that.
