So again, utilizing our unique chemistry, that’s where we’ve been able to see that potency durability and distribution with RNAi. And then that gets the differentiation. And so I think with the ability to have that potency durability, that lets us end distribution, lets us think about differentiation in the target space within CNS and have an alternative approach to be able to look at both conjugated with GalNAc in the liver and beyond to think about the expanded target universe. It’s one of the pieces, as we said, again, in addition to our focus that we’ve been building in AIMers for RNA editing of really unlocking the power of potential genetic target validation. So we’ll get to the targets in the space that we make a unique insight into in development.
So again, early days were last year showing that PN chemistry and our unique chemistry would be applicable to RNAi with the extension of that this year to see it have the opportunity to open up more broadly and to be able to think about this as a powerful tool to use for silencing. And we’ll continue to provide updates as we said later this year on additional potential targets that we can explore. But again, put us in a position of being either first in class in the target or best in class.
Operator: Please standby for our next question. Next question comes from Mani Foroohar with SVB. Your line is now open.
Unidentified Participant: Hi. on for Mani. Thank you for taking our question. Regarding GSK collaboration, so for 006 first, given that this first in human study could potentially derisk RNA editing, how quickly could we expect the expansion of clinical development in other follow on indication? And more broadly, in regard to the collaboration, should we expect to see simultaneous program moving on to the clinic alongside GSK? Or is there a limitation in terms of the number of programs that could be pushed through development every year?
Paul Bolno: Thank you for your question. And again, I’ll pause between them in case it was unclear. So, yes, as you know, the first in human study we announced this year will begin with that translation to the clinic. And I think this is an exciting meaningful inflection for our relationship with GSK. And most importantly for the AATD patients with whom we’re going to accelerate, Wave developing this medicine for initially. I think to your point, the other substantial portion of this collaboration is the research and discovery portion of the collaboration. And I said in the beginning, this is underway. And so, we did say that this has those targets that get selected. There’s a research period where as we said we announced the deal, we could be working on more, what are called, target validation, more programs than they have the ability to select and nominate.
And so, I think what’s exciting for us is, we are working together, we are initiating some of these programs to begin to start working together to understand the target. And I expect over the course of this year, more opportunities to keep you all updated on our progress with that relationship. Both on the targets that GSK is working on, although we may not be able to disclose the targets per se, but at least the momentum on that side of the collaboration. But importantly, on the other side of the collaboration where our access to unique genetic insights enable Wave distillate programs. And those programs, we will be able to share our progress on. So it really is a multi collaboration. I think it’s off to a great start. And obviously, all of that gets driven on the productive translation of the first potential clinical program, excited about our progress.
I’ll pause just because I’ve lost the tail end of your last question just to make sure we answered your question.
Unidentified Participant: Thank you. I guess just as a follow on regarding those, would there be a pathway to potential foster approval in a subset of population for AATD?
