Liisa Bayko: Hi there. Thanks for taking the question. I wanted to circle back to pain and just two questions for me. First of all, the article, so the Editorial [indiscernible] General Medicine did focus in on overwhelmingly more females and the two acute pain indications that you’re using as examples. So maybe you can just speak to that in addressing sort of the underrepresentation of males? And then finally, just if you could comment on any capabilities that you’ve been working on developing. This is obviously a much different market to commercialize into than CF with a lot of generic competition and the need to get on hospital formulary, et cetera, and how are you building sort of those capabilities as you’re waiting for data? Thanks.
Reshma Kewalramani: Sure thing. Liisa, this is Reshma. Let me start and then I’ll pass it over to Stuart. Most companies, including our own, want to ensure that we have more people of color in our trials, more women in our trials, and I guess we have succeeded. So I see the fact that 548 has many women as a positive. Perhaps one point to make underneath, just underline that comment, is remember in the acute pain study one was an abdominoplastyi and abdominoplasty is a procedure involving fat in the belly kind of surgery. Some people call it a tummy tuck, and that is a surgical procedure that more women undergo. With regard to the commercialization of pain, I’ll turn it over to Stuart, but I want to frame up the following concept.
In the acute pain setting, one of the most important elements that VX-548 could address is effective pain relief without the addiction potential of opioids. And that part of it, this addiction potential of opioids is something that is not only of interest to Vertex, but it’s of interest to the community, to policy makers, to physicians, and we see a lot of tailwinds. And so, as I turn it over to Stuart, I’ll ask him to comment on our commercialization efforts, but also the tailwinds we see. Stuart?
Stuart Arbuckle: Yeah, so to your question about capabilities, I think we’re trying to get the best of both worlds. We are trying to leverage the capabilities that have made us be successful to date, And much of that is based around our ability to get reimbursement and access for our medicines and also work with policymakers, with guideline institutions, et cetera, to support the appropriate use of effective medicines like ours. And as Reshma said, we’re already seeing tailwinds, if we can call them that, in the pain market with people looking to move away from the restrictions that they’ve previously put in place for things like opioids in terms of who can prescribe them, for how long, for which patients in which settings, to people looking at policy changes like the No Pain Act, which we highlighted a couple of quarters ago now, where people are looking to make sure that there are no financial barriers or disincentives to people doing the right thing and using a non-opioid effective pain medicine just because there are generic medicines available.
So that’s something that we’re going to be looking to build on, some of the capabilities that we’ve used to help us be successful. Having said that, we are going to be selling into a different segment of the market. This is obviously going to be a very hospital institution driven sale and so we are looking to bring in and have brought in new capabilities as we’ve brought on our paying business unit people who are experienced in that kind of institutional setting. So I would say we’re trying to get the best of both worlds, leverage what we’ve been good at in the past, while bringing in people who bring new knowledge, skills, and experience to the company as well.
Operator: Thanks. The next question will come from Michael Yee with Jefferies. Please go ahead.
