Wall Street’s major indices rebounded anew on Wednesday as worries about tariff policies and the Federal Reserve’s independence tapered off after President Donald Trump assured that he had no intentions of ousting Jerome Powell.
The Nasdaq surged by 2.5 percent, the S&P 500 rose by 1.67 percent, while the Dow Jones increased by 1.07 percent.
Ten companies mirrored the broader market optimism as optimistic investors resumed pouring funds into their stocks. In this article, we have identified Wednesday’s 10 best-performing stocks during the intra-day trading and detailed the reasons behind their strong performance.
To come up with the list, we considered only the stocks with more than $2 billion in market capitalization and $5 million in intraday trading volume.
A man in long sleeves looking at stock market data. Photo by Tima Miroshnichenko on Pexels
10. Palantir Technologies Inc. (NASDAQ:PLTR)
Palantir Technologies Inc. saw its share prices rally by as much as 10.2 percent at intraday trading on Wednesday before closing the day just up by 7.27 percent at $100.82 apiece, as investors cheered news that it partnered with Google to integrate its cloud into the former’s FedStart initiative.
Leigh Palmer, vice president for technology, delivery, and operations at Google’s public sector, said in a statement that the collaboration aims to enhance the delivery of services to US government agencies while upholding the highest security and compliance standards.
Anthropic, Google’s generative artificial intelligence startup, was said to be the first software company to use the new capability. Its Claude for Enterprise application will be available to federal government agencies through PLTR FedStart on Google Cloud.
“By partnering with industry leaders to bring cutting-edge technologies to the US government, Google can accelerate public sector mission impact and outcomes,” Palmer said.
9. XPeng Inc. (NYSE:XPEV)
Chinese EV-maker XPeng Inc. rose for a second day on Wednesday, jumping 10.38 percent at intraday trading before ending the day up by 7.32 percent at $20.47 apiece as investors cheered news of a surge in deliveries in the first quarter of the year, coupled with the upcoming launches of more vehicles.
In a statement on Wednesday, XPEV said global deliveries in the first quarter of the year expanded by 370 percent to 94,008 units from the same period a year earlier, putting its total global deliveries to 700,000 units.
Additionally, its newly unveiled XPENG X9 variant alone received 6,000 firm orders within just seven days from launch.
XPEV also launched what it touted as the next-generation AI brain called XPENG World Foundation Model with 35 times the parameters of conventional vision-language-action models, enabling real-time adaptation to complex driving scenarios. The system’s self-optimizing capabilities enable real-time adaptation to unfamiliar driving scenarios.
8. Oklo Inc. (NYSE:OKLO)
Oklo Inc. grew its share prices for a second day on Wednesday, adding 12.6 percent at intra-day trading before ending the day just up by 8.45 percent at $23.35 apiece as investor sentiment was fueled by its chairman’s resignation to boost ties with other artificial intelligence companies.
In a statement, OKLO said Sam Altman, chief executive officer of OpenAI, has stepped down from his position as chairman of the board. The move was vital in boosting the company’s strategic partnerships with other AI firms and avoiding any conflict of interest.
“As OKLO explores strategic partnerships to deploy clean energy at scale, particularly to enable the deployment of AI, I believe now is the right time for me to step down,” Altman said.
“Historically, energy availability and cost, along with computational limitations, have been fundamental constraints on technological progress. A future where these are no longer limiting factors will be radically different, and I look forward to following Oklo’s leadership in driving this transformation,” he added.
Jacob DeWitte, OKLO’s CEO and co-founder, will replace Altman as OKLO’s chairman.
7. Amphenol Corp. (NYSE:APH)
Amphenol Corp. grew its share prices for a second straight day, jumping 10.43 percent at intra-day trading before paring gains to close just 8.21 percent higher at $71.15 apiece as investor sentiment was boosted by its impressive earnings performance in the first quarter of the year.
In a statement, APH said it achieved a 34.8-percent increase in net income in the first three months of the year at $744.2 million versus the $552 million registered in the same period last year, as consolidated net sales increased by 50 percent to $4.8 billion from $3.2 billion year-on-year.
Despite the improved numbers, APH remained cautious about its business outlook for the second quarter of the year amid ongoing market uncertainties.
“Assuming the continuation of current market conditions as well as constant exchange rates, for the second quarter of 2025, [APH] expects sales to be in the range of $4.9 billion to $5 billion, representing a 36 percent to 39 percent increase over the prior year quarter. Adjusted Diluted EPS is expected to be in the range of $0.64 to $0.66, representing a 45 percent to 50 percent increase from the second quarter of 2024,” it said.
APH designs and manufactures electrical, electronic, and fiber optic connectors and interconnect systems, antennas, sensors and sensor-based products, and coaxial and high-speed specialty cables.
6. Archer Aviation Inc. (NYSE:ACHR)
Archer Aviation saw its share prices rise by 16.2 percent at intra-day trading on Wednesday before paring gains to end just up by 8.2 percent at $71.14 apiece following news that Abu Dhabi officially approved the design for its first hybrid heliport, sparking hopes for ACHR’s looming takeoff.
On Wednesday, the UAE General Civil Aviation Authority approved the design of the first hybrid heliport to be located at the Abu Dhabi Cruise Terminal at Zayed Port, a leading hub for the regional cruise industry that welcomes more than 650,000 visitors annually.
The new heliport was developed in partnership with ACHR, AD Ports Group, and Falcon Aviation Services, and will accommodate both traditional helicopters and electric vertical take-off and landing (eVTOL) aircraft.
The approval complemented ACHR’s planned launch of its Midnight aircraft in Abu Dhabi later this year.
In other news, ACHR said it would begin producing 10 Midnight aircraft at its ARC facility in Covington, Georgia this year to support its ongoing certification-related testing programs and deployments with key partners. It also plans to ramp up the factory’s capacity to a range of 650 to 2,000 aircraft annually.
5. Super Micro Computer Inc. (NASDAQ:SMCI)
Super Micro grew its share prices by 14.4 percent at intra-day trading on Wednesday before ending the day just up 7.59 percent at $32.9 apiece following news that it deepened its collaboration with Fujitsu Limited in AI computing through the launch of PRIMERGY GX2570 M8.
The PRIMERGY GX2570 M8 is an OEM server product created by SMCI that features high-performance GPUs and is designed for large-scale generative AI applications. It will be offered in two cooling configurations: a 10U air-cooled model and a 4U liquid-cooled model, both featuring the advanced NVIDIA HGX B200 GPU.
Beginning July 2025, Fujitsu said that it will combine the said server with its Takane large language model (LLM) for enterprises in a bid to offer managed services for generative AI infrastructure.
“Supermicro is excited to continue its strong relationship with Fujitsu. We believe the combination of Supermicro’s 10U air-cooled model and a 4U liquid-cooled model, both featuring the advanced NVIDIA HGX B200 GPU family, with Fujitsu’s recognized global service offer customers a proven AI solution for the acceleration of AI in the enterprise,” SMCI President and CEO Charles Liang said.
4. Vertiv Holdings Co. (NYSE:VRT)
Vertiv Holdings saw its share prices grow by 21 percent at intra-day trading before ending the day just up by 8.6 percent at $78 apiece as investors snapped up shares in the company following an impressive earnings performance in the first three months of the year.
During the period, VRT said it swung to a net income of $164.5 million from a $5.9 million net loss in the same period a year earlier as net sales increased by 24 percent to $2.036 billion from $1.639 billion year-on-year.
Looking ahead, VRT expects to book net sales between $2.325 billion and $2.375 billion in the second quarter of the year, or an organic growth of 19 percent to 23 percent.
Meanwhile, net sales in the full year were pegged at a range of $9.3 billion to $9.57 billion, or between 16.5 percent and 19.5 percent organic growth.
3. Trump Media & Technology Group Corp. (NASDAQ:DJT)
Trump Media extended its winning streak for a fourth straight day on Wednesday, adding 13.27 percent at intra-day trading before closing the session up by 11.54 percent at $26.38 apiece following announcements that the company will launch its own exchange-traded fund under its financial technology arm Truth.Fi.
Earlier this week, DJT said it partnered with Crypto.com and Yorkville America Digital to launch the ETFs.
The ETFs will be accessible on Crypto’s broker-dealer, Foris Capital LLC, and are expected to include digital assets along with securities that align with the made-in-America approach, covering various industries such as energy.
The initiative remains pending regulatory approval and is expected to be launched later this year. They will be available globally, including the US, Europe, and Asia, across existing platforms and brokerage firms.
2. Summit Therapeutics Inc. (NASDAQ:SMMT)
Summit Therapeutics surged by 23.76 percent at intra-day trading on Wednesday, a fourth straight day, before ending the day just up by 21.5 percent at $33.23 apiece as investor sentiment was boosted by the positive results of its phase 3 study for its lung cancer treatment candidate.
According to SMMT, Akeso achieved a significant milestone in its Phase 3 clinical trial to study ivonescimab’s combination with platinum-based chemotherapy as against the combination of tislelizumab, a PD-1 inhibitor, with the same chemo treatment.
The trial targeted patients with locally advanced or metastatic squamous non-small cell lung cancer (NSCLC) without regard to PD-L1 expression levels.
According to the companies, the combination of ivonescimab and chemotherapy significantly improved progression-free survival (PFS) compared to tislelizumab and chemotherapy. More importantly, no safety issues were recorded during the trial.
Following the clinical update, SMMT earned an Overweight rating from Cantor Fitzgerald, saying that it “continues to view ivonescimab as an asset with a highly binary future: either better than pembro with huge market potential or undifferentiated from pembro and of limited value.”
1. Tempus AI Inc. (NASDAQ:TEM)
Tempus AI extended its winning streak for a third straight day on Wednesday, adding 18.69 percent at intra-day trading before ending the day just up by 14.62 percent at $49.55 apiece after bagging a $200-million partnership with AstraZeneca and Pathos AI for the development of a multimodal foundation model in oncology.
In a statement, TEM said the total amount includes data licensing and model development fees.
The model, which will utilize TEM’s de-identified oncology data, will be used to gather biological and clinical insights, discover novel drug targets, and develop therapeutics for the broader oncology community.
Upon completion, the model will be shared among all three parties to advance their individual efforts to improve patient care.
“Generative AI and the emergence of large multimodal models is the final catalyst needed to usher in precision medicine in oncology at scale,” said TEM CEO Eric Lefkofsky.
“Tempus has spent the last decade investing billions of dollars into collecting the necessary data needed for a foundation model of this kind to take shape. We look forward to working with AstraZeneca and Pathos to apply AI-enabled solutions to advance therapies in an effort to help patients live longer and healthier lives,” he added.
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