SOPHiA GENETICS SA (NASDAQ:SOPH) Q4 2023 Earnings Call Transcript

SOPHiA GENETICS SA (NASDAQ:SOPH) Q4 2023 Earnings Call Transcript March 5, 2024

SOPHiA GENETICS SA misses on earnings expectations. Reported EPS is $-0.37 EPS, expectations were $-0.25. SOPH isn’t one of the 30 most popular stocks among hedge funds at the end of the third quarter (see the details here).

Operator: Good morning. My name is Drew, and I will be your conference operator today. At this time, I would like to welcome everyone to the SOPHiA GENETICS’ Fourth Quarter and Full Year 2023 Earnings Conference Call. All participants will be in listen-only mode. [Operator Instructions] Please note, this event is being recorded. I would now like to turn the conference over to Kellen Sanger, SOPHiA GENETICS’ Head of Strategy and Investor Relations. You may begin.

Kellen Sanger: Thank you, and good morning, everyone. Welcome to the SOPHiA GENETICS’ fourth quarter and full year 2023 earnings conference call. Joining me today to discuss our results are Dr. Jurgi Camblong, our Co-Founder and Chief Executive Officer, and Ross Muken, our Chief Financial Officer and Chief Operating Officer. I’d like to remind you that management will make statements during this call that are forward-looking statements within the meaning of federal securities laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated and you should not place undue reliance on forward-looking statements. Additional information regarding these risks, uncertainties and factors that could cause results to differ appears in the press release SOPHiA GENETICS issued today and in the documents and reports filed by SOPHiA GENETICS from time to time with the Securities and Exchange Commission.

During this call, we will present both IFRS and non-IFRS financial measures. A reconciliation of IFRS to non-IFRS measures is included in today’s earnings press release, which is available on our website. With that, I will now turn the call over to Jurgi.

Jurgi Camblong: Thanks, Kellen, and good morning, everyone. During today’s call, I will start with an overview of our progress in 2023, followed by a quick look at our performance in Q4. Next, I will highlight our key priorities for 2024. Then, Ross will provide a more detailed look at our financial results, business trends and guidance for the upcoming year. Before I get started, I want to take a momentum to reflect on some of the trends we saw in healthcare in 2023 and also more broadly across industry. In many ways, 2023 was the year of AI. It was the first time that the general public gained access to powerful AI models and learn what they can do. As the Co-founder and leader of an AI-driven precision medicine company who has been working on building AI in healthcare since SOPHiA GENETICS’ inception in 2011, this moment has been a fulfilling experience for me.

I will take this opportunity to highlight that since inception 13 years ago, we have invested over $400 million to build some of the most advanced AI capabilities in the healthcare sector. We have recruited a team of more than 200 of the top data scientists and engineers in the world who contribute to building and developing our platform, SOPHiA DDM. SOPHiA DDM today is widely recognized by healthcare professionals for its world-class analytical performance and by some of our partners as the leading AI platform in healthcare. However, at SOPHiA GENETICS, innovation is not the development of new technology, but rather the adoption of those technologies in the market. And in that spirit, let’s turn to 2023 and the progress we made driving adoption of SOPHiA DDM.

2023 was a tremendous year for SOPHiA GENETICS. We grew revenue 31% year-over-year to $62.4 million by continuing to drive widespread adoption of our platform. In 2023, SOPHiA DDM was used by 450 core genomic customers across the globe to perform over 317,000 analyses. This record number of analyses represent a remarkable 27% year-over-year growth when excluding COVID-related volume. At the beginning of 2023, we laid out three primary drivers to achieve our ambitious growth objective. First, we highlighted the large market potential for SOPHiA DDM’s Solid Tumor application. Especially, we expressed excitement over HRD, which was exhibiting workplace analytical performance due to an innovative deep learning algorithm we developed called GIInger.

Second, we highlighted high potential for growth in the U.S. market. And third, we explained that the genomic and multimodal data computed every day on our platform in addition to our advanced AI algorithms being trained on these datasets would create meaningful value for our biopharma partners. I’m proud to say that we delivered in each of these three areas. With respect to SOPHiA DDM Solid Tumor applications and in particular HRD, we saw impressive growth. Solid tumor revenue grew above company average in 2023 and HRD was a major driver with over 150% revenue growth during the period. We’re pleased to see both existing and new customers adopt SOPHiA DDM for Solid Tumor applications. We signed an impressive 36 new logos for Solid Tumor applications in 2023, and by the end of Q4, we were proud to have a total of 129 core genomics customers using Solid Tumor applications.

This group includes nearly 50 customers using SOPHiA DDM for HRD, all of which were attracted by the application’s world-class analytical performance. Moving on to our second growth driver for 2023, the U.S. market. In 2023, U.S. revenue grew 70% to $9.5 million, up from $5.6 million in 2022. We signed nine new core genomic customers in the U.S. in 2023, and we’re proud to welcome some of the top U.S. cancer centers and labs to the SOPHiA DDM network. Apart from customers’ relationships, we also had a landmark year with our partners in the U.S. Namely, we continued to build our strategic partnership with Memorial Sloan Kettering. During 2023, we entered into a partnership with MSK to help them to decentralize their liquid biopsy test, MSK-ACCESS, and their solid tumor test, MSK-IMPACT, and to make these tests available to healthcare institutions across the globe.

We officially launched MSK-ACCESS powered with SOPHiA DDM in December and have been pleased to see strong demand for this application in the market. In the U.S., we announced a number of new signings for MSK-ACCESS powered with SOPHiA DDM and are looking forward to capitalizing on this momentum going into 2024. The third growth driver we focused on in 2023 was delivering value to our biopharma customers. The first way we accomplished this was by a number of deals with biopharma partners where they sponsored the deployment of SOPHiA DDM. Biopharma customers are motivated to do this because they are mutually interested in expanding access to cancer testing. Our partnership with AstraZeneca has been a major proof point in this area. Last month, we announced that AZ sponsored the deployment of SOPHiA DDM’s HRD application across Spain in 2023 with resounding success.

While the deployment of our genomics offering continues to be a key focus for us and our biopharma partners, we have always intended to complement our genomics computing capabilities with multimodal analytics. Multimodal data and multimodal algorithms analyzing that data provides significant value to biopharma companies. 2023 was a landmark year for us in building our multimodal capabilities. We launched SOPHiA CarePath, a model of SOPHiA DDM, which enables customers to perform longitudinal analyses of multimodal patient data. This includes multimodal models designed to predict treatment effects of different therapy decisions. As you can imagine, these capabilities provide differentiated value to our biopharma customers who are willing to pay for the access to the multimodal patient data and to multimodal algorithms, which analyze them.

Towards the end of 2023, we completed a momentous project with one of our key biopharma partners, where SOPHiA CarePath identified a signature in subpopulations of lung cancer patients, which could indicate different treatment effects for a specific drug. We continue to remain excited about these use cases for our multimodal offering and the value these capabilities bring to our biopharma customers. In 2024, we plan to expand the footprint of SOPHiA CarePath beyond lung cancer to breast, prostate and kidney cancer. We recently announced two data partnerships, which will accelerate our progress in this mission. First with MSK, second with Exactis Innovation, a network of 13 hospitals across Canada dedicated to improving cancer survivorship. These partners will help us gain access to valuable multimodal datasets, which will be ingested into SOPHiA CarePath for our biopharma customers to use and access.

Now that I have provided a brief overview of 2023 as well, I would like to spend a minute discussing Q4 2023 performance in more detail. In Q4, we grew revenue 27% year-over-year to $17 million. We performed approximately 85,000 analyses, up 20% year-over-year, including COVID-related analyses or 24% year-over-year growth excluding COVID-related analyses. As of December 31, we had 450 core genomics customers who are using our platform regularly to analyze patients for cancer and rare diseases, up from 434 in the prior year and up 19% sequentially from Q3. Q4 was a great quarter in terms of landing new logos. In the fourth quarter, we landed a resounding 35 new core genomics customers. These customers will add to our total number of core genomic customers over the course of 2024 as they are onboarded on to SOPHiA DDM.

As mentioned previously, it typically takes customers six to nine months to enter routine usage. After landing a new logo, our expand strategy continues to be effective as existing customers adopt more and more applications. As of the end of Q4, 56% of customers were using two or more applications, up from 49% a year ago; 31% of customers were using three or more applications, up from 28% a year ago; and 21% were using four or more applications, up from 17% a year ago. Moreover, our net dollar retention was 130% in Q4 2023, up 2,800 basis points from 102% at the end of 2022. The continued proof of our ability to expand within existing customers exemplifies the importance of landing new customers across the globe. On that note, I will take a quick moment to highlight our progress in a key growth market for us, India, where the usage of our platform grew 70% from 2022 to 2023.

I recently returned from a heartwarming trip across India, visiting our fantastic partners there such as Tata Memorial Hospital in Mumbai and the Institute Rotary Cancer Hospital in New Delhi. I also spent time with our newest partner, Karkinos Healthcare, an oncology platform boldly addressing the over 2 million estimated cancer cases in India each year. Together, we will work with Karkinos to provide genomic testing applications to the population of India in addition to a range of other strategic objectives. I am especially inspired by the shared vision between SOPHiA GENETICS and Karkinos, and I am excited for what this means for the broad deployment of SOPHiA DDM across India. Beyond India, I would like to announce today a few additional major signings and expansions.

In the U.S., we recently signed Lifespan Health System, a network of award-winning hospitals in Rhode Island with dozens of locations across state. Lifespan adopted multiple SOPHiA DDM hem-onc applications due to their top analytical performance and our platform’s ability to seamlessly integrate into the workflow. In Spain, we recently expanded our relationship with the Vall d’Hebron Institute of Oncology, one of the top comprehensive cancer centers in Europe, with adopting SOPHiA DDM Solid Tumor application for HRD. Vall d’Hebron joins other top European cancer centers using SOPHiA DDM for HRD testing, including the top two, namely Gustave Roussy and The Royal Marsden. I’m also excited to announce that in LATAM, we expanded our relationship with Dasa, the largest clinical diagnostics company in Latin America.

Dasa is adopting MSK-ACCESS powered with SOPHiA DDM for liquid biopsy testing. This will be the Dasa’s sixth SOPHiA DDM application. We’re excited to see these customers in addition to the 35 new logos we landed in Q4 2023, beginning ramping up usage of SOPHiA DDM during 2024. Speaking of 2024, let’s move on to our priorities and outlook for the upcoming year. Similar to last year, I will highlight three primary growth drivers. I will then touch on how these growth drivers along with continued fiscal discipline will allow us to achieve profitability in the next two-plus years. First, we are excited to capitalize on the launch of our new liquid biopsy offering, including MSK-ACCESS powered with SOPHiA DDM. We are pleased with the strong demand we are seeing in the market for this application and are excited by our sales pipeline for it, which is approaching double-digit millions.

As an additional catalyst for the growth of our liquid biopsy applications, we recently announced a collaboration with AstraZeneca, in which they will sponsor the deployment of MSK-ACCESS on SOPHiA DDM to customers across the globe during 2024. Our second growth driver for 2024 is the significant opportunity we continue to see in solid tumors. A major tailwind for us in the solid tumor space has been the increasing complexity of signatures. As signature detection becomes more complex, more sophisticated algorithms are needed. One example is our proprietary algorithm GIInger, which was recently published in Cell Reports Medicine for its unique ability to detect the HRD signature. Beyond HRD, we are also using other algorithms to help customers like Boundless Bio detect additional complex signatures such as extrachromosomal DNA, which are present in about 20% of cancer cases.

Not only are we well equipped algorithmically to address this growing demand in solid tumors, but we also have a strong portfolio of comprehensive genomic profiling applications to meet our customers’ needs. This includes the upcoming launch of MSK-IMPACT powered with SOPHiA DDM. Similar to our work with MSK-ACCESS, we will decentralize MSK’s CGP test, MSK-IMPACT, and deploy it to customers worldwide. AstraZeneca joins us in the mission and will also contribute to the deployment of the application to customers across the globe. The third key priority for us in 2024 is continuing the trend of strong growth in the U.S. As mentioned earlier, we picked up significant momentum in the U.S. in 2023. In 2024, we’re looking forward to capitalizing on this momentum and leveraging marquee names to attract other U.S. customers to our network.

Apart from the three growth drivers mentioned today, we’re also delivering a series of targeted high-impact platform and application launches in 2024. We plan to launch new capabilities in hem-onc with an application to measure minimal residual disease for acute myeloid leukemia. We also plan to launch new features in rare and inherited disorders to serve our customers’ needs on world genome sequencing and pharmacogenomics. From a platform perspective, we are launching a full modernization of SOPHiA DDM as we move to web technology and microservices. We will also continue making upgrades to SOPHiA CarePath and its multimodal capability in order to create even more value for our biopharma customers. Based on our current commercial pipeline, we’re confident that these new launches will deliver long-term value to our business.

In summary, 2024 is an exciting year from our liquid biopsy capabilities, to our world-class solid tumor applications, to the momentum we are building in the U.S., we are well equipped for 2024, and as we continue on our path to profitability in the next two-plus years. So, with that, I will now turn it over to Ross, who will provide a more detailed look at our financial results, business trends and guidance for the 2024 year.

Ross Muken: Thank you, Jurgi, and good morning, everyone. I’m pleased to share that despite the challenging macro environment, SOPHiA GENETICS delivered strong performance in the fourth quarter, continuing our commitment to sustainable growth. Total revenue for the fourth quarter of 2023 was $17 million compared to $13.4 million for the fourth quarter of 2022, representing year-over-year growth of 27%. Constant currency revenue growth was 26% and constant currency revenue growth excluding COVID-related revenue was also 27%. Of note, clinical revenue fell in line within our internal plan as consumption trends played out as expected in the second half. However, we did have a small amount of biopharma-related revenue shift from the fourth quarter to the first half of 2024.

As I’ve stated previously, our biopharma revenue is still in its nascent stages and thus you should continue to expect small timing-related recognition impacts over the near to medium term. Platform analyses volume was approximately 85,000 for the fourth quarter of 2023 compared to 71,000 for the fourth quarter of 2022. The 20% year-over-year growth was attributable to the strength of our core platform analyses volume, offset by continued expected decline of COVID-related analyses volume. Excluding COVID-related volume, platform analyses grew a healthy 24% year-over-year in the period. Strength in North America and Asia Pacific highlighted geographic outperformance in the quarter, offsetting a slight moderation in Latin America, which had an overall strong 2023.

From an application standpoint, rare and inherited disease applications outperformed oncology applications in the period given broad demand for exomes despite strong contributions from solid tumor, liquid biopsy and hem-onc applications. Gross profit for the fourth quarter of 2023 was $11.9 million compared to gross profit of $9.6 million in the fourth quarter of 2022, representing year-over-year growth of 24%. Gross margin was 70% for the fourth quarter of 2023 compared with 72% for the fourth quarter of 2022. Adjusted gross profit was $12.5 million, an increase of 25% compared to adjusted gross profit of $10 million in the fourth quarter of 2022. Adjusted gross margin was 73% for the fourth quarter of 2023 compared to 75% for the fourth quarter of 2022.

We continued to benefit in the period from economies of scale related to cloud-based compute and storage costs as well as favorable price capture, partially offset by a challenging prior-year comparable related to sizable Microsoft Azure cloud credits, offsetting our computational and storage-related costs. Excluding this one-time benefit, gross margins would have increased 600 basis points year-on-year. Total operating expenses for the fourth quarter of 2023 were $30.8 million compared to $24.7 million for the fourth quarter of 2022. Across the functions, we continued to benefit from lower headcount both on a year-over-year as well as quarter-on-quarter basis. FX was a notable headwind in the period, particularly impacting R&D expenditures.

On a reported basis, share-based compensation was also a notable headwind broadly. Lastly, I am also proud of our hard work on the G&A side where we continue to benefit from lower professional service fees and optimization of our public company costs. Operating loss for the fourth quarter of 2023 was $18.9 million compared to $15.1 million in the fourth quarter of 2022. Adjusted operating loss for the fourth quarter of 2023 was $13.3 million compared to $12.1 million for the fourth quarter of 2022. We continue to be pleased with our trajectory toward profitability and believe the additional headcount actions we took in the second half of 2023 were necessary to sustain the trend into the first half of 2024. Of note, below the line this quarter, we did have a significant charge related to foreign exchange losses.

This is due to the material appreciation of the Swiss franc and euro in the period. As this is primarily related to intercompany receivables, you will see an immaterial impact on our cash utilization overall. Lastly, total cash burn for the fourth quarter of 2023 was $9.5 million compared to $10.6 million in the prior-year quarter. This represents an 11% year-over-year improvement even when factoring in a credit to computational and storage-related expenses related to our strategic agreement with Microsoft in Q4 2022. We remain happy overall with our cash and utilization trends and are on track with respect to our medium-term liquidity trajectory. Now, turning to full year 2023 financials. Total revenue for the full year 2023 was $62.4 million compared to $47.6 million in 2022, representing year-over-year growth of 31%.

Constant currency revenue growth was 30% and constant currency revenue growth excluding COVID-related revenue was 32%. This outcome was generally in line with our initial forecast and speaks to the level of revenue visibility we continue to have in the business despite ongoing macro and industry-specific headwinds. Platform analyses volume was 317,000 for the full year 2023 compared to 264,000 in 2022, represented 20% year-over-year growth. Excluding COVID-related volume, platform analyses grew at a strong 27% year-over-year in the period. For the full year, oncology application growth outperformed rare and inherited disease applications, led by strength in solid tumors and liquid biopsy. Regional growth was generally balanced with APAC representing the exception, delivering greater than 50% growth.

Core genomic customers were 450 as of December 31, 2023, up from 434 in the prior-year period and up sequentially by 19 customers relative to Q3 2023. Annualized revenue churn rate was 4% in 2023, in line with our expectations. Net dollar retention for the year improved to 130%, up 2,800 basis points from 102% in 2022. Constant currency net dollar retention, excluding COVID-related revenue, was 130% as compared to 123% in 2022. Strong NDR and a healthy level of backlog continued to provide us with a high level of revenue visibility going forward. Gross profit for the full year 2023 was $42.9 million compared to gross profit of $31.3 million in 2022, representing year-over-year growth of 37%. Gross margin was 69% for the full year 2023 compared with 66% for 2022.

Adjusted gross profit was $45 million, an increase of 39% compared to adjusted gross profit of $32.4 million in the full year 2022. Adjusted gross margin was 72% for the full year 2023 compared to 68% for 2022. I am incredibly proud of this outcome as we have now outperformed our medium-term guidance for an entire year. I’ll remain encouraged with respect to continued expansion opportunities moving forward. Total operating expenses for the full year 2023 were $117.7 million compared to $119.1 million in 2022. R&D expenses for the full year were $37 million compared to $35.4 million in 2022. Sales and marketing expenses for the full year 2023 were $28.4 million compared to $28.3 million in 2022. General and administrative expenses for the full year 2023 were $53.3 million compared to $55.8 million in 2022.

Operating loss for the full year 2023 was $74.8 million compared to $87.8 million in 2022. Adjusted operating loss for the full year 2023 was $55.9 million compared to $72 million in 2022. Lastly, total cash burn for the full year 2023 was $55.4 million compared to $86.7 million in the prior year, down 36%. We are quite proud of this achievement and remain committed to sustainable growth moving forward. Cash and cash equivalents were approximately $123.3 million as of December 31, 2023. Now, turning to our 2024 outlook. SOPHiA GENETICS expects full year reported revenue to be between $78 million and $81 million, representing 25% to 30% growth on a reported basis. Let me provide a few key underlying assumptions relative to our reported revenue forecast for 2024.

One, we currently contemplate that exchange rates will remain highly volatile, and as such, we are anticipating a moderate negative impact to reported results in 2024. Two, we also expect a very modest headwind to 2024 reported revenues related to a ceasing of COVID-related contribution. The combined impact of these assumptions would place our implied organic growth rate toward the low end of our medium-term guidance of 30% to 35%. This is despite excellent new customer momentum exhibited in 2023. We would attribute two key factors to a more conservative stance as we approach 2024 revenue guidance. First, we have assumed elongated implementation times for liquid biopsy applications given the complexity of the workflow as compared to tissue.

Further adding complication is a need to help our customers gain access to tumor-normal reference samples for proficiency testing. We currently believe this may add up to three months to implementation timelines, meaning we will likely see a larger impact from recent key wins in 2025. Second, we are seeing increased adoption of new sequencers in the market. This includes companies like Complete Genomics, PacBio, Ultima, Oxford Nanopore and Element. At SOPHiA GENETICS, we welcome this diversity. One of the founding principles of our platform is to be technology agnostic. While the prevalence of these new sequencers is driving opportunity across our offering, the changing adoption pattern also warrants some conservatism about customer readiness to implement our solutions as they first need to manage their sequencer transitions.

Thus, a majority of the growth forecasted in 2024 is from the expansion of existing customers. This is consistent with our historical NDR of 125% to 130%. We will update you over the course of the year as to how new implementations are trending. With respect to seasonality, we would expect 2024 to follow our typical cadence, whereby 1Q and 3Q tend to be seasonally softer from a revenue standpoint, while 2Q and 4Q tend to be seasonally stronger, with 4Q being the largest in terms of percent of revenue contribution to the full year, as many of our recently signed logos will likely begin ramping up at that point. We continue to expect a larger portion of our 2024 revenue to be recognized overall in the second half of the year. Following on our strong cost performance in 2023, SOPHiA GENETICS expects further gross margin expansion from 2023 levels in 2024.

We currently forecast adjusted gross margins for 2024 in the range of 72.5% to 72.7%, representing an improvement of up to 50 basis points. This is despite a challenging comp in the first quarter due to the remaining prior year Microsoft credit. Turning to operating loss. We currently expect adjusted operating loss to fall between $45 million and $50 million. This is yet again another notable improvement from 2023 levels despite a less material benefit year-over-year with respect to headcount, which drove a majority of our loss improvement in 2023. We are confident in our medium-term path to profitability. We have taken the required actions to expedite that goal and remain obsessed with capital efficiency. In the second half of 2023, we took some tactical headcount actions to further optimize our operations while also continuing to focus our R&D efforts on increasingly high ROI projects.

These were difficult decisions, but we prioritized sustaining medium-term revenue momentum at our previously communicated targeted levels, while ensuring a reasonable timeframe to cash flow generation. In 2024, we will continue to revisit our discretionary expenditures and execute and identify savings in systems, professional services and certain public company costs. The combined nature of these items and the natural operating leverage in the business from strong revenue growth will further our path to profitability in the next two-plus years. With that, I would like to turn the call back over to Jurgi for the closing remarks before we take your questions.

Jurgi Camblong: Thank you, Ross. We’re proud of our performance, which we believe reflects our continued ability to execute on our vision and the opportunity ahead. SOPHiA’s success stands on our ability to delight customers and continue driving more and more usage of our platform. After a successful 2023, our focus shifts to SOPHiA’s future. I will share just a few final thoughts as we look towards the near future with three key priorities for 2024. First, we look forward to seeing significant growth from new liquid biopsy applications, including MSK-ACCESS powered with SOPHiA DDM as we deploy the applications to customer worldwide with the help of our biopharma partners. Second, although we set the bar high in 2023, we’re excited to continue growing SOPHiA DDM Solid Tumor applications and capitalize on the demand of increasingly complex signatures.

And third, we plan to continue our strong trajectory of growth in the U.S. as we leverage momentum from 2023. In closing, thank you to our SOPHiA colleagues, partners, customers and investors for joining us in our journey. Without you, none of this would be possible. Please note that we are attending Cowen Health Care Conference tomorrow in Boston and Barclays next week in Miami. I look forward to continuing to update you on SOPHiA’s future success of democratizing data-driven medicine. Operator, you may now open the line for questions.

Operator: Before we begin, I’d like to turn it back over to Ross for a brief statement.

Ross Muken: Thanks. Please note, Jurgi won’t be joining us today for the Q&A portion of the call as he had a minor medical procedure over the weekend. He sends his regards and apologizes for not being able to make it today. We look forward to having him back soon. Now back to you, Drew.

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Q&A Session

Operator: The line is now open for questions. We will now begin the question-and-answer session. [Operator Instructions] The first question comes from Dan Brennan with TD Cowen. Please go ahead.

Dan Brennan: Great. Thanks for the questions, Ross. I hope Jurgi is okay. Maybe just on — first question just on the guide. You talked about the elongated implementation for liquid biopsy and the newer platforms. Could you just contextualize that a little bit, like just size the liquid biopsy business today, kind of frame exactly what’s going on there? And then, on the sequencing side, just give a little more color that like how pervert — how widespread is this new platform adoption? And like in the second quarter, will we be talking about this? Could this be something that lingers throughout the year for you guys? And then I have a few follow-ups. Thanks.

Ross Muken: Thanks, Dan. So, in terms of some of the factors we put into the guidance. So one, I would point you to the fact that we had a tremendous quarter in terms of adding new core logos, right? So, we added 35 in the period. We also had — and again, this is not a number we typically share, we also had incredibly strong bookings toward the end of the year. So, the new demand environment in general is quite healthy. A good portion of that is coming in liquid biopsy. And so, I think that solution, again, relative to tissue is a bit more complex, right? And I think on our end, both given it’s a tumor-normal solution and so that means sample acquisition is a bit more challenging, but also just the workflow for the customer.

We wanted to be a bit more, I would say, conservative and essentially added in our assumption of customers ramping about three months to the adoption process relative to our typical six months. So again, that mathematically would just mean we’re only getting roughly one quarter of contribution from some of those new customers in the year, whereas typically we would get two. So that’s liquid biopsy. On the sequencer side, obviously, this has been a market where you’ve had essentially two players for the majority of the last number of years with one player being quite dominant. We still see obviously no change in sort of the leadership position in the market. But we are seeing quite a number of new vendors having success in different applications within the market.

And so, for us, this is obviously a really nice development. We welcome the diversity of new applications and new sequencer types and vendors. But there is, I would say, to that degree, a bit less certainty for us solely because we have not seen this before, right? And so, again, I wouldn’t say there’s anything we’re necessarily seeing in our setup time that’s elongated, but we wanted to add a bit of cushion, just in case, right? And so, again, I think it’s ultimately on both of these ends, very positive long-term developments for us, but we wanted to be a bit extra conservative as we enter the year just because it does introduce in terms of new business a slightly different wrinkle than we typically have faced in the past.

Dan Brennan: Okay. Got it. Thanks. And then maybe just as a follow-up, it’ll be a two-parter, and then I’ll just go back in the queue. Just biopharma, I think in the 20-F, you noted was up [$3 million] (ph) year-on-year. Could you give us some color what the base was and just any color on the biopharma contribution and how we’re thinking about the impact in ’23? And then, you discussed in the prepared remarks the medium-term path to profitability and the actions that you guys are taking in order to ensure that. I know you haven’t given us a distinct date or timetable, but any more color around what that medium-term path looks like, whether how long, what the revenue base is, what needs to happen? Thank you.

Ross Muken: Excellent, Dan. Thanks for the question. So, in terms of biopharma, so you’ll note we still have not broken that out. And we did obviously also call out in the period that there was a slight amount of revenue that shifted to the first half of next year. I would say that business remains in its nascent stages. We’re still incredibly excited about the opportunity there. We’re seeing quite a lot of synergy between our clinical and pharma business, particularly in liquid biopsy, where I think again, this year, you’ll see continued updates from us on some of the new partnerships and success we’re having there. But I think overall, obviously, longer term for us, on top of what we’ve already done in terms of sponsored testing, we’re very excited about multimodal.

And multimodal for us is very present within sort of the pharma landscape. And that’s where, I would say, stay tuned for some of the other types of projects we’re working on, right? And so, overall, I’m pleased with how pharma performed this year. It actually outperformed our internal expectations. But I would say it’s still small enough as a business relative to the whole, where we’re not quite at the point of breaking it out. And so, the disclosures that you saw show you the nice momentum we’re having, but we’re still at a point where we want you to think about the platform as a whole. In terms of your second question relative to our path to profitability, I’m really proud this year of the work of the team. We did a great job on gross margins.

In this quarter, excluding the Microsoft credit, gross margins were up over 600 basis points. We also made great progress throughout the year on headcount, which is our main expense. And so, we’ll continue to see that improvement play out. As you know, we’re a European entity majority in terms of our headcount mix. And so, it does take some time for headcount actions to work their way through the P&L. So, you’ll continue to see that benefit on OpEx in the first part of next year. And then, we continue to be very disciplined on the rest of our discretionary spend, whether that’s professional services or systems or our real estate, et cetera. And so, we’re constantly looking for areas to target. That being said, I would say from here, the biggest contributor to the path to profitability is going to be the drop down of incremental revenue, right?