Soleno Therapeutics (SLNO): Breakthroughs in Prader-Willi Syndrome Treatment

We recently published a list of 10 Most Promising Small-Cap Stocks According to Hedge Funds. In this article, we are going to take a look at where Soleno Therapeutics, Inc. (NASDAQ:SLNO) stands against other most promising small-cap stocks.

Small-Cap Stocks are Expected to Offer Higher Returns in 2025

Small-cap stocks are offering a myriad of opportunities to investors and are expected to go higher. On September 25, Greg Tuorto, Goldman Sachs asset management portfolio manager, appeared in an interview on Yahoo Finance to discuss his thesis on small-cap stocks.

There have been several tailwinds for small-cap stocks, which may have been ignored previously. However, now that the economy is stabilizing, investors may find a variety of undervalued names in the healthcare and technology sectors especially.

Tuorto further added that small-cap stocks have been underperforming for three years, however, in 2024, there is a lot of pent-up opportunity in this area. A year from now, small-cap stocks are expected to deliver unprecedented returns as the economy continues to grow. He expects more IPOs and mergers and acquisitions to come through before 2024 comes to a close.

Nancy Prial, Co-CEO & Senior Portfolio Manager at Essex Investment Management, is also bullish on small caps. We recently covered her views in our article on the 8 Most Undervalued Small-Cap Stocks To Buy According To Analysts. Here’s an excerpt from it:

“Prial noted that small caps have been outperforming in the third quarter, largely driven by expectations of rate cuts, with a 50 basis point reduction being more significant than previously anticipated. She expressed optimism that small caps have substantial room to grow, emphasizing that this could mark the beginning of a multi-year cycle for these stocks. Currently, small-cap stocks are underrepresented in the market, comprising just under 5% of the total equity market, which is at record lows. This low ownership level presents an attractive opportunity for investors.

She pointed out that small-cap stocks remain significantly undervalued compared to their larger counterparts. Prial argued that for small caps to gain traction, several conditions must be met: the continuation of rate cuts, confidence in navigating a soft landing rather than a recession and expanding relative earnings growth. She noted that relative earnings growth for small caps is starting to improve and is expected to surpass that of large caps by the end of the year.”

Biotechs Set to Raise Millions in IPOs

The biotechnology sector is growing rapidly and a large number of startups are expected to go public. On October 7, Reuters reported that three startups are set to raise $400 million in their initial public offerings, amid the sector’s second IPO boom. In September, several drug developers made their market debuts, raising more than $900 million in their IPOs, encouraging other startups to follow suit.

While there is uncertainty around the presidential elections in the United States, biotechnology startups and companies are benefiting from the declining rate cuts. Experts polled by Reuters suggest that biotech companies are of the view that they should exploit the current market momentum rather than wait for presidential elections to normalize the market. However, this also puts immense pressure on other biotech companies to go public as soon as possible.

Our Methodology

To find the most promising small-cap stocks according to hedge funds, we used the Finviz stock screener. We set the market capitalization filter to range between $300 million and $2 billion. We then examined the hedge fund sentiment of these stocks as of Q2 2024 and picked the most popular ones. The stocks are sorted in ascending order of the number of hedge fund holders as of Q2 2024.

Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 275% since May 2014, beating its benchmark by 150 percentage points (see more details here).

Soleno Therapeutics (SLNO): Breakthroughs in Prader-Willi Syndrome Treatment

A clinical-stage biopharmaceutical company’s boardroom, emphasizing the importance of decision-making for the lead candidate development of a once-daily oral tablet.

Soleno Therapeutics, Inc. (NASDAQ:SLNO)

Number of Hedge Fund Holders: 29

Market Capitalization as of October 10, 2024: $1.99 Billion

Soleno Therapeutics, Inc. (NASDAQ:SLNO) is a specialty biotechnology company that ranks eighth on our list of the most promising small-cap stocks according to hedge funds. The company is currently developing Diazoxide Choline Extended-Release (DCCR), a tablet that treats Prader-Willi Syndrome (PWS), a genetic disorder.

The drug has already completed its phase 3 trials and is currently being evaluated in a phase 3 clinical development program. As for PWS, the five major concerns for Soleno Therapeutics, Inc. (NASDAQ:SLNO) include reducing hunger, improving behavior around food, enhancing metabolic health, reducing temper, and reducing OCD. The tablet also has the potential to treat other diseases such as obesity-associated mutations and life-threatening hypoglycemia.

In the second quarter of 2024, Soleno Therapeutics, Inc. (NASDAQ:SLNO) submitted a New Drug Application to the U.S. Food and Drug Administration (FDA) for the usage of DCCR as a treatment of PWS. During the same quarter, the company achieved a significant milestone after it was granted the “Breakthrough Therapy” designation for DCCR as a treatment for patients with genetically confirmed PWS and hyperphagia.

In Q2 2024, the company spent $12.3 million on research and development, compared to $5.1 million in the same quarter in 2023. Soleno Therapeutics, Inc. (NASDAQ:SLNO) is accelerating its communications with the FDA and is also working to improve supply chain activities. Overall, the company is positioned for solid growth in the coming years.

Overall, SLNO ranks 8th on our list of most promising small-cap stocks according to hedge funds. While we acknowledge the potential of SLNO as an investment, our conviction lies in the belief that AI stocks hold greater promise for delivering higher returns, and doing so within a shorter time frame. If you are looking for an AI stock that is more promising than SLNO but that trades at less than 5 times its earnings, check out our report about the cheapest AI stock.

READ NEXT: $30 Trillion Opportunity: 15 Best Humanoid Robot Stocks to Buy According to Morgan Stanley and Jim Cramer Says NVIDIA ‘Has Become A Wasteland’.

Disclosure: None. This article is originally published at Insider Monkey.