We recently compiled a list of the 10 Stocks With At Least $30 Million In Insider Spending Recently. In this article, we are going to take a look at where Septerna, Inc. (NASDAQ:SEPN) stands against the other stocks. We previously covered 10 stocks with at least $20 million in insider spending recently.
Trump administration’s tariffs on goods imported from Canada and Mexico, as well as additional duties on China, took effect yesterday. As expected, the stock market reacted immediately. The technology index fell 1.2%, hitting its lowest point in almost four months, wiping out post-election gains, while blue-chip companies declined 1.5% or 650 points.
“Tariffs of these magnitude will drive both Canada and Mexico into a recession,” JP Morgan analysts wrote in their daily Tuesday note, writes The Street. Analysts added that higher costs and supply-chain disruptions will affect U.S. growth and domestic stocks. The tariffs could impact $2.2 trillion of global trade and provoke economic slowdowns in the U.S.
Many analysts have downgraded their U.S. stock projections, believing that strong earnings in 2025 may be more challenging. The broader market index is expected to finish the year around 9% higher than in 2024, but that’s still lower than the early January forecast of 12.2%.
The biggest potential positive factor, many experts are banking on, is a productivity boost from AI and expected lower interest rates. Morgan Stanley’s Andrew Slimmon suggests that the adoption of AI could lead to a productivity boom, similar to what happened with the Internet in the late 1990s.
With market fluctuations and uncertainty at play, insider trading draws attention. Executives and insiders, who possess valuable insights into company strategies, plans, and future moves, may engage in trades worth examining. For example, when a CEO or CFO invests their own money in company stock, it can signal strong confidence in the company’s potential.
Insider buying and selling can be influenced by a range of factors, so these actions should be evaluated in the broader context of a company’s financial health, industry trends, and overall market conditions. This underscores the importance of thorough research before making any investment. While insider trading activity can provide useful insights into a company’s potential, it should be considered alongside other key factors to help investors make well-informed decisions.
Today, we’ll focus on stocks with at least $30 million in insider spending. We used Insider Monkey’s stock screener to find stocks where at least one insider purchase in the last five months was worth $30 million or more. While the total value of all insider purchases could be higher, we only looked at those over $30 million. Since more than 10 stocks met these criteria, we chose the top 10 with the largest insider purchases above $30 million.
Our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds, focusing on insider trading and stock picks from hedge fund investor newsletters and conferences. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 373.4% since May 2014, beating its benchmark by 218 percentage points (see more details here).
For each stock, we provide details on the highest individual purchase, the number of insider purchases higher than $30 million over the last three months and the company’s current market capitalization. Let’s take a look at 10 stocks with at least $30 million in insider spending recently.

A biotechnologist in a lab wearing an apron and safety glasses, working on a biopharmaceutical process.
Septerna, Inc. (NASDAQ:SEPN)
Highest Individual Purchase: $68,911,200.00
Number of Purchases Above $30 million: 1
Market Capitalization: $273.521 million
Seventh among 10 stocks with at least $30 million in insider spending recently is Septerna, a clinical-stage biotech. The South San Francisco-headquartered company is engaged in the discovery and development of G protein-coupled receptor oral small molecule product candidates.
Septerna is focused on three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. This is one of the 10 best rebound stocks to invest in now.
On October 28, one insider acquired $68.91 million worth of Septerna, Inc. (NASDAQ:SEPN) shares at a price of $18 per share. Currently, the stock is trading at $6.16 having lost 73.10% since the beginning of the year. The biggest drop in the stock’s price of 57% happened on February 18 after the company announced it would stop the Phase 1 clinical trial of SEP-786. One of its previously leading drug candidates SEP-786 targets a GPCR implicated in hypoparathyroidism. The decision came after two participants in the trial experienced an unexpected increase in bilirubin levels, which is a potential sign of liver issues. The elevated bilirubin levels were reversible, and the company did not find any evidence of serious adverse events in the trial.
For the third quarter of 2024, the company reported revenue of $176,000, which compares to revenue of $33,000 in the same period of 2023. Net loss attributable to common stockholders amounted to $20.52 million, compared to a net loss of $10.95 million in the third quarter of 2023.
Four analysts have an average “Moderate Buy” on Septerna, Inc. (NASDAQ:SEPN) stock, with a price target of $34, according to MarketBeat.
Overall SEPN ranks 7th on our list of the stocks with at least $30 million in insider spending recently. While we acknowledge the potential of SEPN as an investment, our conviction lies in the belief that AI stocks hold greater promise for delivering higher returns, and doing so within a shorter time frame. If you are looking for an AI stock that is more promising than SEPN but that trades at less than 5 times its earnings, check out our report about the cheapest AI stock.
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Disclosure: None. This article is originally published at Insider Monkey.