Page 11 of 15 SEC Filing Name Date Number of Shares Transaction Price/Share Footnotes 667, L.P. 02/24/16 4,850 Purchase 29.7746 1 Baker Brothers Life Sciences, L.P. 02/24/16 43,056 Purchase 29.7746 1 667, L.P. 02/24/16 466 Purchase 28.4650 Baker Brothers Life Sciences, L.P. 02/24/16 4,134 Purchase 28.4650 667, L.P. 02/24/16 7,593 Purchase 28.5233 2 Baker Brothers Life Sciences, L.P. 02/24/16 67,407 Purchase 28.5233 2 667, L.P. 02/25/16 14,447 Purchase 29.8633 3 Baker Brothers Life Sciences, L.P. 02/25/16 128,255 Purchase 29.8633 3 667, L.P. 02/26/16 4,485 Purchase 30.1342 4 Baker Brothers Life Sciences, L.P. 02/26/16 39,815 Purchase 30.1342 4 667, L.P. 02/29/16 5,955 Purchase 30.5484 5 Baker Brothers Life Sciences, L.P. 02/29/16 54,439 Purchase 30.5484 5 667, L.P. 02/29/16 18,866 Purchase 30.3425 6 Baker Brothers Life Sciences, L.P. 02/29/16 172,462 Purchase 30.3425 6 667, L.P. 03/01/16 2,386 Purchase 31.2443 7 Baker Brothers Life Sciences, L.P. 03/01/16 21,814 Purchase 31.2443 7 667, L.P. 03/02/16 32,934 Purchase 32.7574 8 Baker Brothers Life Sciences, L.P. 03/02/16 301,066 Purchase 32.7574 8 667, L.P. 03/02/16 6,508 Purchase 32.2400 Baker Brothers Life Sciences, L.P. 03/02/16 59,492 Purchase 32.2400 667, L.P. 03/04/16 4,496 Purchase 31.6820 9 Baker Brothers Life Sciences, L.P. 03/04/16 41,104 Purchase 31.6820 9 667, L.P. 03/04/16 23,908 Purchase 32.4927 10 Baker Brothers Life Sciences, L.P. 03/04/16 218,550 Purchase 32.4927 10 667, L.P. 03/07/16 4,597 Purchase 33.6757 11 Baker Brothers Life Sciences, L.P. 03/07/16 40,921 Purchase 33.6757 11 667, L.P. 03/07/16 1,590 Purchase 33.7250 12 Baker Brothers Life Sciences, L.P. 03/07/16 14,157 Purchase 33.7250 12 667, L.P. 03/08/16 5,504 Purchase 32.1486 13 Baker Brothers Life Sciences, L.P. 03/08/16 48,996 Purchase 32.1486 13 667, L.P. 03/08/16 9,968 Purchase 32.1658 14 Baker Brothers Life Sciences, L.P. 03/08/16 88,732 Purchase 32.1658 14
(1) The reported price is a weighted average price. These shares
were traded in multiple transactions at a prices ranging from $29.00 to $29.94. The Reporting Persons undertake to provide the
Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the “Staff”), upon
request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.
(2) The reported price is a weighted average
price. These shares were traded in multiple transactions at prices ranging from $28.50 to $28.57. The Reporting Persons undertake
to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the number of
shares traded at each separate price within the ranges set forth in this footnote.
(3) The reported price is a weighted average
price. These shares were traded in multiple transactions at prices ranging from $29.55 to $30.00. The Reporting Persons undertake
to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the number of
shares traded at each separate price within the ranges set forth in this footnote.
(4) The reported price is a weighted average price. These shares
were traded in multiple transactions at prices ranging from $29.84 to $30.50. The Reporting Persons undertake to provide the Issuer,
any security holder of the Issuer, or the Staff, upon request, full information regarding the number of shares traded at each separate
price within the ranges set forth in this footnote.
Page 11 of 15 Pages
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Name | Date | Number of Shares | Transaction | Price/Share | Footnotes |
667, L.P. | 02/24/16 | 4,850 | Purchase | 29.7746 | 1 |
Baker Brothers Life Sciences, L.P. | 02/24/16 | 43,056 | Purchase | 29.7746 | 1 |
667, L.P. | 02/24/16 | 466 | Purchase | 28.4650 | |
Baker Brothers Life Sciences, L.P. | 02/24/16 | 4,134 | Purchase | 28.4650 | |
667, L.P. | 02/24/16 | 7,593 | Purchase | 28.5233 | 2 |
Baker Brothers Life Sciences, L.P. | 02/24/16 | 67,407 | Purchase | 28.5233 | 2 |
667, L.P. | 02/25/16 | 14,447 | Purchase | 29.8633 | 3 |
Baker Brothers Life Sciences, L.P. | 02/25/16 | 128,255 | Purchase | 29.8633 | 3 |
667, L.P. | 02/26/16 | 4,485 | Purchase | 30.1342 | 4 |
Baker Brothers Life Sciences, L.P. | 02/26/16 | 39,815 | Purchase | 30.1342 | 4 |
667, L.P. | 02/29/16 | 5,955 | Purchase | 30.5484 | 5 |
Baker Brothers Life Sciences, L.P. | 02/29/16 | 54,439 | Purchase | 30.5484 | 5 |
667, L.P. | 02/29/16 | 18,866 | Purchase | 30.3425 | 6 |
Baker Brothers Life Sciences, L.P. | 02/29/16 | 172,462 | Purchase | 30.3425 | 6 |
667, L.P. | 03/01/16 | 2,386 | Purchase | 31.2443 | 7 |
Baker Brothers Life Sciences, L.P. | 03/01/16 | 21,814 | Purchase | 31.2443 | 7 |
667, L.P. | 03/02/16 | 32,934 | Purchase | 32.7574 | 8 |
Baker Brothers Life Sciences, L.P. | 03/02/16 | 301,066 | Purchase | 32.7574 | 8 |
667, L.P. | 03/02/16 | 6,508 | Purchase | 32.2400 | |
Baker Brothers Life Sciences, L.P. | 03/02/16 | 59,492 | Purchase | 32.2400 | |
667, L.P. | 03/04/16 | 4,496 | Purchase | 31.6820 | 9 |
Baker Brothers Life Sciences, L.P. | 03/04/16 | 41,104 | Purchase | 31.6820 | 9 |
667, L.P. | 03/04/16 | 23,908 | Purchase | 32.4927 | 10 |
Baker Brothers Life Sciences, L.P. | 03/04/16 | 218,550 | Purchase | 32.4927 | 10 |
667, L.P. | 03/07/16 | 4,597 | Purchase | 33.6757 | 11 |
Baker Brothers Life Sciences, L.P. | 03/07/16 | 40,921 | Purchase | 33.6757 | 11 |
667, L.P. | 03/07/16 | 1,590 | Purchase | 33.7250 | 12 |
Baker Brothers Life Sciences, L.P. | 03/07/16 | 14,157 | Purchase | 33.7250 | 12 |
667, L.P. | 03/08/16 | 5,504 | Purchase | 32.1486 | 13 |
Baker Brothers Life Sciences, L.P. | 03/08/16 | 48,996 | Purchase | 32.1486 | 13 |
667, L.P. | 03/08/16 | 9,968 | Purchase | 32.1658 | 14 |
Baker Brothers Life Sciences, L.P. | 03/08/16 | 88,732 | Purchase | 32.1658 | 14 |
(1) The reported price is a weighted average price. These shares
were traded in multiple transactions at a prices ranging from $29.00 to $29.94. The Reporting Persons undertake to provide the
Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the “Staff”), upon
request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.
(2) The reported price is a weighted average
price. These shares were traded in multiple transactions at prices ranging from $28.50 to $28.57. The Reporting Persons undertake
to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the number of
shares traded at each separate price within the ranges set forth in this footnote.
(3) The reported price is a weighted average
price. These shares were traded in multiple transactions at prices ranging from $29.55 to $30.00. The Reporting Persons undertake
to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the number of
shares traded at each separate price within the ranges set forth in this footnote.
(4) The reported price is a weighted average price. These shares
were traded in multiple transactions at prices ranging from $29.84 to $30.50. The Reporting Persons undertake to provide the Issuer,
any security holder of the Issuer, or the Staff, upon request, full information regarding the number of shares traded at each separate
price within the ranges set forth in this footnote.
Page 11 of 15 Pages