Page 12 of 16 – SEC Filing 667, L.P. 9/13/2016 2,445 Purchase 50.4214 26 Baker Brothers Life Sciences, L.P. 9/13/2016 21,804 Purchase 50.4214 26 667, L.P. 9/13/2016 101 Purchase 50.6370 27 Baker Brothers Life Sciences, L.P. 9/13/2016 899 Purchase 50.6370 27 667, L.P. 9/13/2016 6,565 Purchase 51.4057 28 Baker Brothers Life Sciences, L.P. 9/13/2016 58,541 Purchase 51.4057 28 667, L.P. 9/13/2016 2,730 Purchase 51.5457 29 Baker Brothers Life Sciences, L.P. 9/13/2016 24,339 Purchase 51.5457 29
(1) The reported price is a weighted average price. These shares
were traded in multiple transactions at a prices ranging from $45.40 to $46.00. The Reporting Persons undertake to provide the
Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the “Staff”), upon
request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.
(2) The reported price is a weighted
average price. These shares were traded in multiple transactions at prices ranging from $44.83 to $45.00. The Reporting Persons
undertake to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(3) The reported price is a weighted
average price. These shares were traded in multiple transactions at prices ranging from $46.02 to $46.15. The Reporting Persons
undertake to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(4) The reported price is a weighted
average price. These shares were traded in multiple transactions at prices ranging from $45.18 to $46.15. The Reporting Persons
undertake to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(5) The reported price is a weighted
average price. These shares were traded in multiple transactions at prices ranging from $45.00 to $45.15. The Reporting Persons
undertake to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(6) The reported price is a weighted
average price. These shares were traded in multiple transactions at prices ranging from $46.00 to $46.25. The Reporting Persons
undertake to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(7) The reported price is a weighted average price. These shares
were traded in multiple transactions at prices ranging from $48.21 to $48.35. The Reporting Persons undertake to provide the Issuer,
any security holder of the Issuer, or the Staff, upon request, full information regarding the number of shares traded at each separate
price within the ranges set forth in this footnote.
Page 12 of 16
| 667, L.P. | 9/13/2016 | 2,445 | Purchase | 50.4214 | 26 |
| Baker Brothers Life Sciences, L.P. | 9/13/2016 | 21,804 | Purchase | 50.4214 | 26 |
| 667, L.P. | 9/13/2016 | 101 | Purchase | 50.6370 | 27 |
| Baker Brothers Life Sciences, L.P. | 9/13/2016 | 899 | Purchase | 50.6370 | 27 |
| 667, L.P. | 9/13/2016 | 6,565 | Purchase | 51.4057 | 28 |
| Baker Brothers Life Sciences, L.P. | 9/13/2016 | 58,541 | Purchase | 51.4057 | 28 |
| 667, L.P. | 9/13/2016 | 2,730 | Purchase | 51.5457 | 29 |
| Baker Brothers Life Sciences, L.P. | 9/13/2016 | 24,339 | Purchase | 51.5457 | 29 |
(1) The reported price is a weighted average price. These shares
were traded in multiple transactions at a prices ranging from $45.40 to $46.00. The Reporting Persons undertake to provide the
Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the “Staff”), upon
request, full information regarding the number of shares traded at each separate price within the ranges set forth in this footnote.
(2) The reported price is a weighted
average price. These shares were traded in multiple transactions at prices ranging from $44.83 to $45.00. The Reporting Persons
undertake to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(3) The reported price is a weighted
average price. These shares were traded in multiple transactions at prices ranging from $46.02 to $46.15. The Reporting Persons
undertake to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(4) The reported price is a weighted
average price. These shares were traded in multiple transactions at prices ranging from $45.18 to $46.15. The Reporting Persons
undertake to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(5) The reported price is a weighted
average price. These shares were traded in multiple transactions at prices ranging from $45.00 to $45.15. The Reporting Persons
undertake to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(6) The reported price is a weighted
average price. These shares were traded in multiple transactions at prices ranging from $46.00 to $46.25. The Reporting Persons
undertake to provide the Issuer, any security holder of the Issuer, or the Staff, upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(7) The reported price is a weighted average price. These shares
were traded in multiple transactions at prices ranging from $48.21 to $48.35. The Reporting Persons undertake to provide the Issuer,
any security holder of the Issuer, or the Staff, upon request, full information regarding the number of shares traded at each separate
price within the ranges set forth in this footnote.
| Page 12 of 16 |
