Sarepta Therapeutics, Inc. (NASDAQ:SRPT) Q3 2023 Earnings Call Transcript

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Joseph Schwartz: Great. Thanks very much for fitting me in. I was wondering how are you thinking about upcoming clinical data for a different gene therapy candidate, which will have an interim look soon. Is there anything that you’ll be focused on in particular? And how do you see the trade-off between safety and efficacy. If it were able to produce a greater impact on FAA, how would that impact your relative value proposition for ELEVIDYS?

Douglas Ingram: Thank you for the question. Look, as I’ve said many times before, we have in front of us an exceptionally ferocious competitor and that Duchenne muscular dystrophy. And all of our focus and all of our energy is in beating the damn disease. And I think this team is doing a brilliant job of that. We’re exceptionally pleased with the performance of ELEVIDYS. There were some — many years ago, people made decisions about constructs and capsids and the like. And with the benefit of many years of experience, we are exceptionally proud of. And frankly, nothing less than thrilled with the particular capsid and construct that we have. It’s shown not only, but it is able to intervene protect these muscles of these children and arrested decline but it couldn’t do that with a particularly laudable safety profile given the amount of therapy required here and the fact that it’s full body infusions.

RH74 has been a standout. And we’re quite confident that anyone who is rational who had an opportunity to make a decision today about what capsid they would use and what construct they would develop. I’m sure they would do their best to try to copy us. So we’re — we’re not focused on any competitor besides Duchenne muscle dystrophy, and we are ferociously committed to beating this disease. So that’s our focus right now. But thank you very much for your questions.

Operator: I would now like to turn the call back over to Doug for closing remarks.

Douglas Ingram: Well, thank you very much, Michelle. And thanks, everyone, for attending tonight, and thank you for your very thoughtful questions. Let me summarize. This quarter has been an extraordinarily important one. With our fourth approval, we launched ELEVIDYS and in my opinion, we launched it brilliantly. We’ve continued to serve the community with our PMOs, which continue robust growth even in the face of an ELEVIDYS launch. And on a non-GAAP basis, we are now profitable, and we are marching toward a cash flow positive in the very near future. We have built a strong enduring organization that is focused on two major things. The first is serving our patient community through brilliant science and the second is executing and getting things done.

And that is precisely what we will be doing over the coming months. We intend to continue our strong performance and commitment to serving this community. We intend to move with speed to submit our efficacy supplement and conclude the review on the broadening of the ELEVIDYS label. And when our label has been updated to remove age and ambulation restrictions, we intend to bring this therapy to the majority of patients living with Duchenne in the United States. And with that, I look forward to updating all of you on our progress along the way and have a lovely evening. Thank you.

Operator: This concludes today’s conference call. Thank you for participating. You may now disconnect.

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