Sarepta Therapeutics, Inc. (NASDAQ:SRPT) Q1 2023 Earnings Call Transcript

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The good news for all of us is that 9001 is going to be watched by Sarepta. And at the risk of sounding a bit immodest, in my view, there is no team better than this Sarepta team to serve these patients, work intelligently with payers and gain access for this therapy for these kids as rapidly as possible. And I am quite confident that’s going to occur and quite confident payers are going to do the right thing. And certainly I believe that they’re going to do the right thing in the context of accelerated approval, which is from our perspective, the approach that one should be taking with respect to 9001, given the data that we have in front of us.

Dallan Murray: Yes. And I think Doug’s really covered it. There are as we said in the opening remarks, really constructive great dialogue going on with the payers. And right now we’re at the – we’re prior to launch they’re asking great questions about the timing and the patient population. And I think more specifically, calling to your question, regardless of when the policies are put in place, the payers are going to look at each patient on a case by case basis. And so the team, as Doug said, is ready to manage that, right, from day one.

Doug Ingram: We’re experienced in battle hardened team.

Operator: Thank you. Our next question comes from the line of Judah Frommer with Credit Suisse. Your line is now open.

Judah Frommer: Hi. Thanks for taking the question. Another one sort of from the payer angle. Any idea if there could be kind of a difference in ramp for patients that are, I guess naive to RNA therapies versus those that are on the PMOs gaining access? And then any indications around potential value based payments given, like you said, this is going to be the biggest gene therapy launch ever. So from a cost perspective, could there be any, I guess, interesting dynamics to the time of payments? Thank you.

Doug Ingram: Yes. As it relates to the first question, I don’t think there’s going to be a difference in ramp. I think this is a – for those who are amenable to this therapy, which at launch we are successful in our BLA would be ambulant patients, excluding a very narrow range of mutations who are rh.74 negative. I think this therapy is going to be extraordinarily important. And I think that there’s going to be an equal ramp, whether you’re naive or not naive to the PMOs. And in fact, we have dosed patients that have been on the PMO and remained on the PMO post dose. So we have good data that supports that. On the value-based agreements and the like, I’m not at a place right now where we’re going to discuss those issues yet.

I will tell you that we have done an enormous amount of work about, which I am extremely impressed and proud to frame the value proposition in the pharmacoeconomic model for one-time therapies like SRP-9001. And our approach to the payer community, pricing, value-based agreements and the like, will be inside the frame of that value framework itself. And the one thing I will tell you qualitatively at least, and then we’ll at the right time talk quantitatively, is that the value that this therapy will bring to Duchenne patients is going to be significantly greater than the cost of this therapy for the healthcare system, which is what we all should want.

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