RA Capital Management Bets Another $20 Million On Kala Pharmaceuticals Inc.

	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549	OMB APPROVAL
		OMB Number:     3235-0145 Expires:   February 28, 2009 Estimated average burden hours per response…   10.4

SCHEDULE 13D

 

Under the Securities Exchange Act of 1934

 

(Amendment No. 1)*

 

	Kala Pharmaceuticals, Inc.
	(Name of Issuer)
	Common Stock, par value $0.001 per share
	(Title of Class of Securities)
	483119103
	(CUSIP Number)

RA Capital Management, LLC

20 Park Plaza, Suite 1200

Boston, MA 02116

Telephone: 617.778.2512

Attn: Peter Kolchinsky

(Name, Address and Telephone Number of Person
Authorized to
Receive Notices and Communications)

	October 3, 2018
	(Date of Event Which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G
to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e),
240.13d-1(f) or 240.13d-1(g), check the following box. ¨

Note: Schedules filed in paper format shall include a signed
original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting
person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing
information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall
not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).

CUSIP No. 483119103

1	Names of Reporting Persons. RA Capital Management, LLC
2	Check the Appropriate Box if a Member of a Group (See Instructions)
	(a)      ¨
	(b)      ¨
3	SEC Use Only
4	Source of Funds (See Instructions): AF
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e): ¨
6	Citizenship or Place of Organization.      Massachusetts

Number of Shares Beneficially Owned by Each Reporting Person With	7      Sole Voting Power      0 shares
	8      Shared Voting Power      4,537,478 shares
	9      Sole Dispositive Power      0 shares
	10    Shared Dispositive Power      4,537,478 shares

11	Aggregate Amount Beneficially Owned by Each Reporting Person 4,537,478 shares
12	Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)     ¨
13	Percent of Class Represented by Amount in Row (11) 14.1%1
14	Type of Reporting Person (See Instructions) IA, OO (Limited Liability Company)

¹
The reporting person is the beneficial owner of 4,537,478 shares of
the Issuer’s Common Stock which constitute approximately 14.1% of the class outstanding.
The percentage calculation assumes that there are currently 32,106,674 outstanding shares
of Common Stock of the Issuer, based on the Issuer’s Prospectus as filed with the
Securities and Exchange Commission (“SEC”) on October 3, 2018. 

CUSIP No. 483119103

1	Names of Reporting Persons.   Peter Kolchinsky
2	Check the Appropriate Box if a Member of a Group (See Instructions)
	(a)      ¨
	(b)      ¨
3	SEC Use Only
4	Source of Funds (See Instructions): AF
5	Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e): ¨
6	Citizenship or Place of Organization.      United States

Number of Shares Beneficially Owned by Each Reporting Person With	7      Sole Voting Power      0 shares
	8      Shared Voting Power      4,537,478 shares
	9      Sole Dispositive Power      0 shares
	10    Shared Dispositive Power      4,537,478 shares

11	Aggregate Amount Beneficially Owned by Each Reporting Person 4,537,478 shares
12	Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)     ¨
13	Percent of Class Represented by Amount in Row (11) 14.1%2
14	Type of Reporting Person (See Instructions) HC, IN

² The reporting person is
the beneficial owner of 4,537,478 shares of the Issuer’s Common Stock which constitute approximately 14.1% of the class
outstanding. The percentage calculation assumes that there are currently 32,106,674 outstanding shares of Common Stock of the
Issuer, based on the Issuer’s Prospectus as filed with the Securities and Exchange Commission (“SEC”) on October
3, 2018.

CUSIP No. 483119103

This Amendment No. 1 amends and supplements
the statement on Schedule 13D (the “Statement”) originally filed with the Securities and Exchange Commission on February
14, 2018 by the Reporting Persons with respect to the Common Stock, $0.001 par value (the “Common Stock”), of Kala
Pharmaceuticals, Inc. (the “Issuer”).   Unless otherwise defined herein, capitalized terms used in this
Amendment No. 1 shall have the meanings ascribed to them in the initial Statement.

Item 3. Source and Amount of Funds or Other Consideration

Item 3 of the Statement is hereby amended
and supplemented as follows:

On October 3, 2018, the Reporting Persons purchased
2,424,242 shares of Common Stock of the Issuer for $19,999,996.50. The shares were purchased with working capital.

Item 4. Purpose of Transaction

 

Item 4 is hereby supplemented as follows:

The Reporting Persons acquired the Common Stock
referred to in Item 3 for investment purposes and not with an intent, purpose or effect of changing control of the Issuer.

 

Item 5. Interest in Securities of the Issuer

(a) and (b) See Items 7-11 of the cover pages
and Item 2 above.

(c) The following table lists the Reporting
Persons’ transactions in Common Stock that were effected during the sixty day period prior to the filing of this Schedule
13D:

Transaction		Date		No. Shares		Price
Purchase		3-Oct-2018		2,000,301* and 423,941		$	8.25

Shares marked with an * were acquired by the
Fund. The remaining shares were acquired for the Account.

(d) Not applicable.

(e) Not applicable.

Item 7. Material to Be Filed as Exhibits

Exhibit 1

Joint Filing Agreement by and among the Reporting Persons is incorporated herein by reference to Exhibit 1 to the Schedule 13D filed by the Reporting Persons with the Securities and Exchange Commission on February 14, 2018.

CUSIP No. 483119103

SIGNATURE

 

After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date:

October 5, 2018

	RA CAPITAL MANAGEMENT, LLC
	By: /s/ Peter Kolchinsky
	Peter Kolchinsky
	Manager
	PETER KOLCHINSKY
	/s/ Peter Kolchinsky