Protagonist Therapeutics Inc (PTGX): RA Capital Management Acquires 6.8% Stake

Page 2 of 7 – SEC Filing

CUSIP No. 74366E102

13G

	1.	Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only). RA Capital Management, LLC
	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a) ¨
		(b) ¨
	3.	SEC Use Only
	4.	Citizenship or Place of Organization         Massachusetts

Number of Shares Beneficially Owned by Each Reporting Person With	5.	Sole Voting Power                           0
	6.	Shared Voting Power             1,109,229
	7.	Sole Dispositive Power                 0
	8.	Shared Dispositive Power      1,109,229

	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,109,229
	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)      ¨
	11.	Percent of Class Represented by Amount in Row (9) 6.8%1
	12.	Type of Reporting Person (See Instructions) IA

¹
The reporting person is the beneficial owner of 1,109,229 shares of Common Stock which constitutes approximately 6.8% of the Issuer’s
outstanding Common Stock shares. The percentage calculation assumes that there are currently 16,323,551 outstanding shares of Common
Stock, after the completion of the Issuer’s initial public offering, as reported in the Issuer’s final prospectus filed
with the Securities and Exchange Commission (“SEC”) on August 12, 2016.