Rob Davis: Yes. And Steve, just to maybe, from a commercial perspective, build on the question, from a launch timing perspective, our expectation is that we would be in the market in 2025. And obviously, we are working to be ready for that season in 2025. And then from – a differentiator for us, recall that our coverage covers what is the full prevention season for RSV, which is five months to six months. We are a single fixed dose, not a weight-based administered shot. So, for us, those are all very important things. And the last thing I would note is the site of action for us is really, we think, has low risk of development of resistance and is different than the competition. So, we actually are very bullish on this. I think we don’t talk about it, frankly, because we have so many other good things to talk about.
It sometimes gets lost. But it doesn’t mean we are not excited about this and/or dengue, which frankly, I still believe dengue is a little bit, obviously, later than this, but huge for us. So, those were things we are excited about. It just reinforces the breadth of the portfolio we have.
Peter Dannenbaum: Thank you, Steve. Next question please, Ivy.
Operator: Next we will go to the line of Chris Shibutani from Goldman Sachs. Please go ahead.
Chris Shibutani: Thank you. If I could ask about immunology, essentially a reentry into that realm with the Prometheus acquisition, if you could just update us on what we should be expecting to learn and also what you find interesting perhaps being to further build out on the immunology platform. Specifically, the clinicaltrials.gov has the Phase 2 maintenance data and UC is enrolling. Should we expect to hear from you on results there? I did not observe something there on Crohn’s disease. What’s the update on that program? And then in immunology further, it appeared from the start of the year a lot of excitement about different modalities, cell therapies in particular, oral advanced treatments. Share with us some views on where you think immunology could go to take Merck to be a relevant presence in the 2030s. Thank you.
Dean Li: Chris, that’s a great question and an expansive question. So, let me just hit in relationship to the TL1A antibody. We have our ulcerative colitis trial moving forward, and that’s been listed and that’s moving forward. I think probably the really important thing for me that I look out is getting the Crohn’s disease trial moving. The reason I think it’s really important is I will remind myself that TL1A is in the super TNF family. But TL1A may be different than run-of-the-mill TNF in its ability to not just dampen inflammation, but affect fibrosis. So, going from ulcerative colitis to Crohn’s disease, Crohn’s disease has lots of strictures in this. That will be important. And it will be also important to look and follow – I follow our data in TL1A in relationship to lung disease and scleroderma.
So, that’s with that. I would also emphasize that there are other assets within the partnership or acquisition that we did with Prometheus and those compounds, which had already been discussed previously are advancing through the pipeline as well. And then the other question that you have is, are we interested in other platforms and moving forward, the answer is absolutely yes. I think you had a question in terms of cell therapy with immunology. I think there is interesting there. But as you know, we have – when we have looked at cell therapy in relationship to cancer, especially not in heme, but in solid, we have been a little bit probably more exploratory. And right now, our view of cell therapy in immunology is one that might be more similar to our view of cell therapy in solid tumor, a little bit more exploratory.
Peter Dannenbaum: Great. Thank you, Chris. Ivy, we have time for one more question please.
Operator: And for our final question, we will go to the line of Louise Chen from Cantor Fitzgerald. Please go ahead.
Louise Chen: Hi. Thanks for taking my question. I just wanted to ask you on your ADC platform, if you feel that what you have is enough for now or do you want to expand or add on to it. And any interest in radiopharmaceuticals? Thank you.
Dean Li: Thank you very much for that question. So, when we think about tissue targeting, we think of ADCs. And the answer is, I think the ADC fields will continue to develop, and I think there will be other payloads, other linkers, but also the specificity by which you do the tissue targeting in relationship to the antibody may change. There is also clearly evidence of potential movements into peptide drug conjugates that we are interested in as well as the possibility that the payload is no longer chemotherapy-based, but other sort of compound-based. So, we are interested in that. In tissue targeting more broadly, we are interested, and so we view that as, okay, that’s how we are going to move sort of toxic cell chemotherapy agents into tissue targeting sort of scheme making chemotherapy precision medicine.
But we also are very interested in the IO space in relationship to tissue targeting, and that is – our foray in that is really helped by our proposed acquisition with Harpoon that has a very interesting asset in relationship to tissue targeting and immune engagers.
Peter Dannenbaum: Great. Thank you, Louise and thank you all for the really good questions and appreciate you sticking to mostly one question. We got to a lot of questioners, so appreciate that. If you have any follow-ups, please reach out to IR. We will be seeing you soon. Thank you.
Operator: Thank you all for participating in the Merck & Company Q4 sales and earnings conference call. That concludes today’s conference. Please disconnect at this time and have a great rest of your day.
