Merck & Co. Inc. (MRK): Billionaire D.E. Shaw Is Bullish On This Stock Right Now

We recently compiled a list of the 10 Best Stocks to Buy According to Billionaire D.E. Shaw. In this article, we are going to take a look at where Merck & Co. Inc. (NYSE:MRK) stands against the other stocks.

Equity market pricing is never perfect due to supply and demand imbalances, emotional reactions, and errors. Billionaire investor David Elliot Shaw excels at detecting and exploiting these inefficiencies to generate shareholder value. Unlike most hedge fund managers who rely on intuition, Shaw uses sophisticated mathematical models and algorithms for investment decisions. Over the years, he has developed software and hardware to gain an edge in investment opportunities.

Born in 1951, David E. Shaw became a successful billionaire scientist and hedge fund manager. After earning a PhD from Stanford in 1980, he founded D.E. Shaw & Co. in 1988 with six employees and $28 million in capital. The hedge fund has averaged a 12.5% return since inception, with only one down year. Shaw’s firm uses powerful computers and advanced algorithms for quick market responses and risk management, returning over $51 billion to investors. Likewise, it generated a net return of 11.88% between 2001 and 2011. While Shaw’s firm was down by 9% at the height of the financial crisis in 2008, it bounced back to profitability with a 21% return in 2009.

READ ALSO: 10 Best Stocks to Buy According to Billionaire David Einhorn and Billionaire Paul Singer’s Top 12 Long-Term Stock Picks.

D.E. Shaw is expanding and launching new funds. In 2023, they raised money for D.E. Shaw Alkali Fund VI, the newest in their Alkali group. By November 2024, they had secured $1 billion for this fund, focusing on corporate debt, structured credit, and synthetic securitizations.

Last year, the firm also raised $1.1 billion for two new private investment vehicles: D.E. Shaw Voltaic Fund and D.E. Shaw Diopter Fund. In June 2024, D.E. Shaw announced it was raising its second fund in 16 months to target bank capital deals. They filed a private placement notice for D.E. Shaw Diopter Fund II, but the amount wasn’t disclosed.

Bloomberg reported that D.E. Shaw’s largest hedge fund, the D.E. Shaw Composite Fund, gained 9.6% in 2023, outperforming the HFR Global Hedge Fund Index, which was up about 2.5% through December 15. Reuters added that D.E. Shaw’s macro-oriented fund, the Oculus Fund, gained 7.8% in 2023, beating its macroeconomic peers. According to Bloomberg, the Oculus Fund has never had a negative year since it started.

Diversification is another vital arsenal that D.E. Shaw & Co. relies on to spread risk and reduce market volatility. The firm is highly diversified with a portfolio value of about $116.49 billion. While technology stocks account for the most significant share in the equity market at 24.6%, the hedge fund also has stakes in Services at 17.5% and the financial sector at 7.7%. In addition to diversifying holdings, Shaw relies on a multi-strategy approach to squeeze optimum value in the market.

Billionaire D.E. Shaw suggests investing in resilient companies, even as the US Federal Reserve signals fewer interest rate cuts in 2025. Despite three cuts reducing the benchmark rate to 4.25%-4.5%, economic slowdown concerns persist, especially in the labor market. Job growth is mainly in government and health care, while growth in manufacturing, business, and professional services has stagnated.

Our Methodology

To make the list of best stocks to buy according to billionaire D.E. Shaw, we scanned D.E. Shaw & Co investment portfolio. We then settled on the hedge fund’s largest holdings analyzing why they stand out and the number of hedge funds that hold stakes in them. Finally, we ranked the stocks in ascending order based on D.E. Shaw & Co stake value.

At Insider Monkey, we are obsessed with the stocks that hedge funds pile into. The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 275% since May 2014, beating its benchmark by 150 percentage points (see more details here).

Is Merck & Co. Inc. (MRK) Cheap NYSE Stock To Invest In Now?

A close-up of a person’s hand holding a bottle of pharmaceuticals.

Merck & Co. Inc. (NYSE:MRK)

D.E. Shaw & Co’s Stake Value: $767.79 Million

Number of Hedge Fund Holders: 86

Merck & Co. Inc. (NYSE:MRK) is a healthcare company that offers pharmaceutical products for human health in the areas of oncology, neuroscience, and diabetes, among others. Its lead product is Keytruda, a lead cancer drug approved for 40 different oncology indications. The medicine may be approved for a number of new indications, including small-cell lung cancer and ovarian cancer, with continued clinical trials and increased research and development (R&D) funding.

Merck & Co. Inc. (NYSE:MRK) is already looking into the future as it looks to reduce its reliance on Keytruda. The company already has more than 30 programs in phase clinical trials, with an additional 80 in phase 2 trials. The company has also moved to strengthen its prospects in the weight loss business by signing a licensing agreement with Chinese biopharma Hansoh Pharma.

The deal paves the way for the company to commercialize the Chinese company’s oral weight loss candidate HS 10535. Hansoh will get an upfront payment of $112 million from Merck & Co. Inc. (NYSE:MRK), with additional milestone payments of up to $1.9 billion possible.

Merck & Co. Inc. (NYSE:MRK) sees potential in HS-10535, which is still in the experimental stage, and this is reflected in the financial terms of the agreement. The company’s dedication to expanding its R&D pipeline in a therapeutic area with substantial unmet medical needs is demonstrated by the upfront payment and subsequent milestone payments.

Oakmark Equity and Income Fund stated the following regarding Merck & Co., Inc. (NYSE:MRK) in its Q3 2024 investor letter:

“Merck & Co., Inc. (NYSE:MRK) is a global pharmaceutical firm with leading oncology, vaccine and animal health franchises. Premier products in Merck’s portfolio include Keytruda, Gardasil, Winrevair and Bravecto. Outsized contributor Keytruda is an immuno-oncology drug that treats several cancers and tumors. Keytruda is an astounding clinical and commercial success that is on track to become one of the best-selling prescription drugs to date. Investor angst surrounding Keytruda’s pending U.S. patent expiration in 2028 presented a chance to buy shares at a discounted valuation. We believe opportunities to extend Keytruda’s duration through life cycle management are underappreciated. More importantly, discounted cash flows from products already on market cover today’s entire stock price, meaning there is minimal value ascribed to a promising pipeline with strong sales potential. We believe Merck is led by a capable management team that looks to reinvest these cash flows in an accretive manner.”

Overall MRK ranks 6th on our list of the best stocks to buy according to Billionaire D. E. Shaw. While we acknowledge the potential of MRK as an investment, our conviction lies in the belief that under the radar AI stocks hold greater promise for delivering higher returns, and doing so within a shorter timeframe. If you are looking for an AI stock that is more promising than MRK but that trades at less than 5 times its earnings, check out our report about the cheapest AI stock.

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Disclosure: None. This article is originally published at Insider Monkey.