Kymera Therapeutics, Inc. (NASDAQ:KYMR) Q1 2024 Earnings Call Transcript

Kymera Therapeutics, Inc. (NASDAQ:KYMR) Q1 2024 Earnings Call Transcript May 3, 2024

Kymera Therapeutics, Inc. isn’t one of the 30 most popular stocks among hedge funds at the end of the third quarter (see the details here).

Operator: Good day, and welcome to the Kymera Therapeutics First Quarter 2024 Results Conference Call. All participants will be in the listen-only mode. [Operator Instructions] After today’s presentation, there will be an opportunity to ask questions. [Operator Instructions] Please note that this event is being recorded. I would now like to turn the conference over to Justine Koenigsberg. Please go ahead.

Justine Koenigsberg: Thank you. Good morning, and welcome to Kymera’s quarterly update call. Joining me this morning are Nello Mainolfi, President and CEO; Jared Gollob, our Chief Medical Officer; and Bruce Jacobs, our Chief Financial Officer. Following our prepared remarks, we will open the call to questions. To have enough time to address everyone’s questions, we ask that you please limit your questions to one, and a relevant follow-up. Before we begin, I would like to remind you that today’s discussion will include forward-looking statements about our future expectations, plans, and prospects. These statements are subject to risks and uncertainties that may cause the actual results to differ materially from those projected.

A description of these risks can be found in our most recent 10-Q filed with the SEC. Any forward-looking statements speak only as of today’s date, and we assume no obligation to update any forward-looking statements made on today’s call. With that, I’ll now turn the call over to Nello.

Nello Mainolfi: Thank you, Justine. Good morning, everybody. It’s been a very productive beginning of 2024, starting in January with an extensive update at our Immunology R&D Day, and a subsequent financing to provide capital that we will invest in our expanding clinical development efforts and growing pipeline. Past quarters we focused on execution on both our preclinical and clinical pipeline, as well as external engagement across the variety of business and medical conferences. Today, our plan is to share a brief update on our programs, as well as timelines for new [indiscernible] we’re expecting through the rest of this year, and early ’25. As we shared earlier this year, we believe we have a significant opportunity to address and expand the existing treatment paradigms within immunology by developing compelling oral small molecule degrader medicine with biologics-like activity.

As has been the case all the way back to the starting of the company, we have taken a differentiated approach to target selection and focused on critical molecular pathways that are well validated through human genetics, clinical evidence, and/or the success of approved drugs. Many of these pathways play a key role in immune-mediated disease pathology. And while injectable biologics dominate these markets, often due to their strong clinical activity, they’re not without limitations, which in many instances can limit penetration. As a result, we believe developing convenient oral options with biologics-like activity and good safety profile represents an enormous opportunity to expand patient access in many of these markets that are currently dominated by injectable agents.

Our IRAK4 program, which was our first program to enter clinical development that simplifies a target and a pathway that has the potential for a broad patient impact. We have talked in the past about our reasons for enthusiasm around IRAK4 as a target, and our rationale for pursuing it. IRAK4 is an obligate node in IL-1R/TLR signaling, and believe its degradation is the only approach to fully block the pathway, creating multiple development opportunities in large [indiscernible] indications. In the KT-474, IRAK4 Phase 1 trial we observed deep and well-tolerated degradation, early signs of clinical efficacy, and high fidelity of translation from preclinical models to patients, which provide key insights for our growing immunology pipeline, and position future programs such as our STAT6 and TYK2 degrader programs for success.

In March, we had the opportunity to showcase our proprietary immunology programs, KT-621, our STAT6 degrader, and KT-294, our TYK2 degrader at the American Academy of Dermatology Annual Meeting. The poster presentations, which marked the first data from a STAT6 targeted agent and the TYK2 degrader to be shared at a major medical meeting highlighted our robust preclinical packages, and support the significant potential of our oral degrader in this pathway. In our KT-621 AAD poster, we highlighted the preclinical efficacy studies comparing KT-621 to dupilumab in a preclinical atopic dermatitis model. Importantly, KT-621 shows robust activity in vivo in this model, equal or superior to dupilumab. KT-621 degradation STAT6 was well tolerated in multiple preclinical safety studies at dosage and concentration up to 40-fold above the projected human executions concentration.

If we can indeed deliver biologics-like activity and good safety profile at oral once-daily dosing, we believe KT-621 could change the treatment paradigm for millions of patients suffering from Ph2-driven information. In terms of timing, KT-621 is currently IND enabling studies, and is on track to enter Phase 1 testing in the second-half of 2024. It’s our intent to conduct a Phase 1 healthy volunteer study to assess single and multiple ascending doses of KT-621, and move quickly from there into patients. We have finalized our clinical development plans and strategy, and we look forward to sharing more details as we move closer into clinical data. Moving to TYK2, we shared a poster in AAD that demonstrated [indiscernible] inhibition of the IL-23, IL-12, and Type 1 interferon pathway, showing KT-294’s potential to recapitulate the biology of human TYK2 loss of function in patients.

The biological differentiation of KT-294 from [indiscernible] small molecule inhibitors will demonstrating through [indiscernible] compared to [Supra] (ph), which is important in inflammatory bowel syndrome, as well as was shown through superior inhibition of Type 1 interferon pathway compared to TAK-279, which is relevant for the treatment of several diseases including interferon-related diseases. Additionally, KT-294 demonstrated decent sustained TYK2 knockdown in vivo with low daily oral doses. We believe that this data demonstrates that a TYK2 degrader has the potential to deliver best-in-class TKY2 pathway blockade with productivity across multiple IL-12, 23, and Type 1 interferon-driven immune-inflammatory diseases. We intend to continue to share updates across our pipeline in medical meetings in 2024.

In fact, later this month, we present poster highlighting KT-621 and its potential to treat Ph2 allergic diseases at both the American Thoracic Society International Conference, in San Diego, as well as at the Digestive Disease Week, in D.C. These presentations which build on what was previously shared at the R&D Day will include new exciting additional preclinical data. To sum up my intro here, since our founding day, years ago, a milestone which we will commemorate just in a few days, we have demonstrated consistent and scalable innovation, including strong preclinical to clinical translation of degradation safety and activity across the whole pipeline. We have also achieved early proof of concept in both immunology and oncology, which we believe is a significant accomplishment for the new modality.

As we are transitioning from early to mid-late development across our pipeline, we remain committed to building on our early success and expanding our team and capabilities to deliver on the substantial clinical and commercial opportunities that our programs offer, to ultimately become a global commercial stage medicines company. In the meantime, we look forward important and near-term data readouts in this year in oncology, and multiple readouts from our immunology pipeline in ’25. I’ll pause here, and ask Jared to provide an update on our clinical programs. Jared?

Jared Gollob: Thanks, Nello. I’ll round out the immunology discussion this morning with IRAK4, and then give an update on our two clinical oncology programs. Our first-in-class oral IRAK4 degrader, KT-474 is progressing in two Phase 2 trials in hidradenitis suppurativa and atopic dermatitis. These trials are being conducted by Sanofi under our collaboration, and we expect to be in a position to share top line data in the first-half of 2025. Recall that Sanofi moved this program into Phase 2 studies based on the early clinical data we generated in HS and AD patients in Phase 1 trial. In that study, not only did we achieve our study objectives in terms of PK, PD, and safety, but we also delivered encouraging signs of clinical activity that we will also evaluate over a longer dosing period in the Phase 2 trials.

These randomized placebo-controlled trials represent an opportunity to demonstrate the potential for IRAK4 degradation generally, and KT-474 specifically to transform the treatment of complex inflammatory diseases and to offer HS and AD patients well-tolerated, effective, and convenient oral medicine. So, switching gears now to oncology, I’ll start by noting that we recently presented scientific data on our oncology pipeline in both the late-breaking poster session and during the major symposium at the AACR Annual Meeting. As we shared in the past, our preclinical and early clinical findings, highlighted last month at the meeting, support the advantages of degraders over other existing technologies and agents, and further validate our differentiated molecular design, target selection, and translational strategies to advance a new generation of medicines for patients.

KT-253, our highly potent degrader of MDM2 E3 ligase that modulates the most common tumor suppressor p53, is currently in development for the treatment of liquid and solid tumors. Preliminary data from the Phase 1 clinical trial showed evidence of target engagement and in p53 pathway activation, along with initial signs of anti-tumor activity with out dose-liming toxicity, including typical hematological toxicity. These findings support our therapeutic hypothesis for MDM2 degraders, and the potential to improve the therapeutic index compared to MDM2 small-molecule inhibitors. As we finish dose escalation of the Phase 1 trial this year, we hope to see anti-tumor activity in a variety of tumor types. And coupled with our biomarker selection strategy, we plan to assess these data collectively to inform next steps.

Finally, on MDM2, we are announcing today that we’ve had an abstract accepted for a poster presentation at ASCO, in June, where we will provide a clinical data update. Once the trial is completed, we expect to present the full dataset at a medical meeting later in the year. KT-333, our highly selective degrader of STAT3, a traditionally undrugged transcription factor recognized as a key component of the JAK/STAT signaling pathway with both tumor cell intrinsic and tumor cell extrinsic effects on the tumor microenvironment is currently in development for the treatment of multiple STAT3-dependent pathologies, including hematological malignancies and solid tumors. Preliminary data from the Phase 1 trial demonstrated early signs of anti-tumor activity at doses that were generally well tolerated and associated with substantial STAT3 knockdown in blood and tumor.

Our preclinical to clinical translation showed some early but encouraging responses in both CTCL and Hodgkin’s lymphoma. We also demonstrated stimulation of an inherent gamma response in tumor and blood, which is encouraging given the correlation between interferon gamma and how tumors respond to anti-PD-1 drugs. Dose escalation in the KT-333 Phase 1 study is ongoing, with the goal to further assess safety and anti-tumor activity in both liquid and solid tumors. We expect to complete the study this year, and deliver additional proof of concept data to define KT-333’s path for late-stage development. We are also announcing that we’ve had an abstract accepted for presentation at the European Hematology Association, or EHA meeting, in June, where we will present a clinical update.

We plan to present the full dataset at a medical meeting later in the year. Now, I’ll hand the call over to Bruce to share financials for the quarter. Bruce?

Bruce Jacobs: Thanks, Jared. I’ll quickly review our first quarter 2024 financial highlights, and you can certainly reference the tables down in today’s press release. Revenue in the first quarter of 2024 was $10.3 million. All of that was attributable to our Sanofi collaboration. And just a quick reminder, we had received or have received $55 million in total milestones as a result of the start of the two Phase 2 studies in the fourth quarter of last year. With respect to operating expenses, R&D for the quarter was $48.8 million, about $6.1 million of that represented non-cash stock-based comp, resulting in an adjusted cash R&D spend of $42.7 million, a 10% decrease from the comparable amount in the fourth quarter of 2023. On the G&A side, our spending for the quarter was $14.4 million, of which $5.9 million was non-cash stock-based comp.

The adjusted cash G&A spend of $8.5 million, again excluding the stock-based comp, reflects a 1% decrease from the comparable sequential quarter. Our cash balance at the end of the first quarter was $745 million. In January, as we mentioned, we realized approximately $300 million in net proceeds from our equity offering. And our cash balance is expected to provide a runway into the first quarter of 2027, and that will enable us to execute on multiple — or I should say, the first-half of ’27. That will enable us to execute on multiple data readouts including oncology proof of concept results in 2024, KT-474 Phase 2 data expected in the first-half of 2025, and several clinical inflection points for our STAT6 and TYK2 programs, also in 2025. So, this concludes our prepared remarks.

We’d be happy to take your questions. Operator, if you could open the line for questions? Thank you.

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Q&A Session

Operator: Thank you. We will now begin the question-and-answer session. [Operator Instructions] The first question is from the line of Brad Canino from Stifel. Please go ahead.

Brad Canino: Great, thanks so much for the question. It looks like we’re going to get two bites out of the apple for MDM2 this year. And, generally, I would assume that the completed 1A and the biomarker data later this year would be most material. So, just to not overlook what’s coming at ASCO, can I have you talk about the decision to present here what should be the focus and how should investors view it within the broader trial and strategy for the asset? Thank you.

Nello Mainolfi: So, thanks, Brad. So, just taking a step back, this is a program that we started clinical data then in the second-half, roughly the mid of last year. And our first update was our [indiscernible] call in November, if you recall, of last year. And we presented really limited data. And as we, since then, recruited many more patients in the solid tumor lymphoma arm as well as open [DML] (ph) arm, we thought it was important to connect with the medical community and, obviously, the investor community to give an update on the progress we’ve made in both arms of the trial that I believe would shine more light on the potentials of MDM2 across the subset of patients, and also create more enthusiasm, hopefully if we can, to continue to recruit the right type of patients to our study.

So, and obviously, when we share data there are multiple audiences. And the investor community being one of them that the goal is to complete, as we said in the press release, this Phase 1 dose escalation study by the end of the year. And then, yes, provide a full update, as well as plans for further development later in the year. But given the substantial [depth] (ph) our patients recruited between November and now, we thought this would be a good update to showcase the progress in the program.

Brad Canino: Okay, thanks for that. And then, Nello, I know you took part in a targeted protein degradation symposium at AACR. I’d just love to hear what your general insights were, thoughts were exiting that about the evolution of this therapeutic area? Thank you.

Jared Gollob: Yes, that’s a great question, Brad. So, firstly was a great meeting, I believe that I saw you there. It was very well attended, let’s call it, symposium, with many companies presenting. I actually hadn’t been in a TPD-focused symposium in probably too long. And so, it was great to see a huge amount of interest from many stakeholders in the state. I saw many physicians, I saw other small and large companies. So, I think the level of interest is increasing with the data, especially clinical data that different companies are sharing. I also came home with a great feeling that companies, like Kymera, are really leading the field here in terms of capabilities, target cell action, sophistication of approach. And so, I think, generally, with still a lot of work to do for the field, but I’m glad that we and others are leading in providing hopefully good examples for others to follow.

Operator: Thank you. We move to the next question. The next question is from the line of Ellie Merle from UBS. Please go ahead.

Unidentified Analyst: Hey, it’s Sam on for Ellie. I guess just in line with the previous question, from the MDM2 update at ASCO, can you provide any color on, I guess, like the extent of data that we could be expecting from the study, and I guess what kind of efficacy measures we should anticipate to look for? And what are you guys looking for from the data as you think about the development path forward?

Jared Gollob: Hey, great, thanks for the question. I mean, this is really a planned to be a clinical update for the Phase 1a dose escalation, so really to show the progress that we’ve made since last November. So, the goal is to share additional information on the types of patients we’ve enrolled, both solid tumor patients as well as patients with hematologic malignancies, to share the safety that we’ve been seeing as we’ve been dose-escalating to share more data on the pharmacodynamic effect of the drug. Recall that back in November we did show an impact on GDF15, which is this key biomarker just downstream of MDM2, so our aim is to show more data that provides that sort of information on pharmacologic engagement, and of course to provide whatever response data we have, clinical response data we have for patients with solid tumors and patients with hematologic malignancies.

Unidentified Analyst: Okay, great. Thank you so much. And I guess just a quick follow-up. Does any color on the updates for the biomarker patient selection strategy you guys are pursuing, and how is the progress kind of going there?

Jared Gollob: Yes, I think that’s an important question. I think Nello mentioned that earlier, which has been an important part of the program for MDM2, in addition to being able to demonstrate that the therapeutic index with our degraders is superior, as we’ve seen with MDM2 inhibitors, is to eventually be able to evolve a sort of patient selection strategy, or so-called sort of biomarker strategy for selecting patients who we think will be most sensitive to this treatment. We don’t plan on providing that particular update at ASCO, but our anticipation is that later in the year, preferably at a medical meeting, we’ll provide more of those data showing our progress preclinically, and even perhaps some of our clinical data that have been informing our ability to develop a patient selection biomarker strategy focusing on those patients who we think we’ll be able to predict would be most sensitive to MDM2 degradation.

Operator: Thank you. We move to the next question. The next question is from the line of Michael Schmidt from Guggenheim Securities. Please go ahead.

Unidentified Analyst: Good morning. This is [indiscernible] for Michael. We want to get your thoughts on recent [RAINBOK] (ph) data that showed superiority over Dupixent. As you think about the opportunity for your IRAK4 and STAT6 degraders, do the level-up results shift the bar for an oral agent in AD and potential other indications? And as a related question, what’s your strategy on future head-to-head studies against biologics for your overall II portfolio? Thank you.

Nello Mainolfi: Yes, that’s a great question. I don’t think we’re learning today that inhibiting JAK kinase is an extremely powerful anti-inflammatory mechanism. In fact, I think if you look across several indications, not only in AD, you see JAK inhibitors being extremely, extremely active. So, I don’t believe we learned anything new. I think what we are proposing here at Kymera is to use protein degradation to go after targets that provide the best efficacy to safety profile. So, the opportunity here is to have an oral drug that is well-tolerated, that does not require blood or minor blood testing or monitoring of patients for severe cardiovascular events. So, I don’t think this bar has moved at all. I think the field is still looking for oral agents that are active, that have a well-tolerated profile. And that’s really what we’re trying to do for both IRAK4 and STAT6 and TYK2 in a different way, obviously, we can discuss each program individually. Next question?

Operator: Thank you. The next question is from the line of Eric Joseph from J.P. Morgan. Please go ahead.

Eric Joseph: Hi, good morning. I just wanted to get a little bit of a better sense of what your internal bar is for moving 253 into later-stage development. I wonder whether key opportunities in heme malignancy will be strategically attractive enough, or do you want something broader that encompasses all tumors as well? And additionally, is the focus more on moving forward with a monotherapy strategy? Would you be amenable to combination approaches? Thanks.

Nello Mainolfi: Yes, thanks, Eric. Maybe I’ll start and then pass it to Jared. First, I would say the reason why we got involved with MDM2, which, as we all know, is a target that has been pursued by the whole industry in the past 15 years or so. So the reason for us to do so is to really unlock a broad variety of tumor types that we have seen are extremely sensitive to removal of MDM2, which is quite different, in our view, from inhibition of MDM2 KT-333 interaction that small-molecule inhibitors do. So, as Jared was saying, we have developed a sensitivity map, let’s say, across tumor types that point to a subset of tumors in which we’ve seen preclinically. And we’ll start sharing some clinical data. But we’ve seen preclinically, at least I can say so far, to be extremely sensitive to this mechanism.

And those go across both heme as well as solid tumors. I think we’ve shown already preclinically that AML, especially both as a single agent as well as combo, we’ve seen some really, really almost best-in-class activity. And this is an area that we would pursue independently of the opportunity in solid tumors, given the higher-med need and still the relevant commercial opportunity for both first-line but also for refactoring AML. So, I think I would say that the AML opportunity is, in a way, independent of solid tumor. But I also would want to say that the impetus to work on MDM2 was to go also beyond heme oncology. So, we have, hopefully, exciting plans that we can share with you based on biomarker strategies that see us expanding in solids as well.

Eric Joseph: Great. I appreciate it. Thanks for taking the question.

Operator: Thank you. The next question is from the line of Kalpit Patel from B. Riley. Please go ahead.

Unidentified Analyst: Hi, this is Jeff for Kalpit. Thanks for taking my question. Just one on the STAT6 program, the question is, if you have the opportunity to discuss the development of your STAT6 degrader with a Sanofi. If so, could you share any insights into why perhaps Sanofi opted to collaborate with another STAT6 degrader company instead? Thank you.

Nello Mainolfi: Yes, so as we said repeatedly in the past, I’ll say this again today, we started this program a few years ago. We have built a conviction around our ability to use oral degraders in immunology starting from an early stage in our report. And we have decided that we have no interest in partnering our immunology pipeline in order to, at least in the foreseeable future, in order to fulfill our vision to building a global integrated company. I’m not going to obviously share discussions that we’ve had with Sanofi, but I would say generally this is a program that has been pursued from other parties quite heavily in terms of potential partnership. But our communication has been very clear that we believe this is a program that we want to develop as a standalone independent company for the foreseeable future.

I will also remind everybody that we are the first company to take a STAT6 degrader. Actually, I would say STAT6 agent overall in the clinic was the first company to demonstrate the preclinical activity of such an agent. And everybody else is obviously years behind us.

Unidentified Analyst: Okay. Thank you. That’s very helpful.

Operator: Thank you. The next question is from the line of Andy Chen from Wolfe Research. Please go ahead.

Andy Chen: Hey, good morning. Thank you for taking the question. Two related questions also on STAT6. Just curious if you can talk about tissue distribution, so I see deep degradation in the skin in non-human primates. I’m just curious how well this tissue distribution translates to humans. I’m curious if you can cite several precedents where this non-human primate distribution is highly correlated to humans. And also, in the first half of 2025, are we going to gain any insight on this exact topic? What kind of metrics will we have when determining whether STAT6 is indeed acting on the skin in humans? Thank you.

Nello Mainolfi: Yes. No, it’s a great question. So, first, for people that have followed us over the past few years know that we don’t discuss preclinical data of PK and distribution besides the degradation data that we show in our presentations. And that’s only because we believe those are highly confidential and important data that we want to keep for ourselves at this point. But I will say that if you look at the data we presented, we’ve shown that KT-621 degrades STAT6 equally effectively in several tissues, in skin, in lung, in blood. And I believe in spleen too. I’m not sure we’ve shown that or not. But we’ve shown that the distribution of the drug allows for, I would say, generally equivalent degradation across all TH2-relevant tissues.

And so, our expectation is to see in the clinic the same level of response. And we’ve seen good translation of preclinical into clinical in terms of distribution across different species. I would say that, yes, in the first half of 2025, our goal is to share Phase I data. If it’s being publicly disclosed, then the Phase I data will involve both blood and skin biomarkers.

Andy Chen: Thank you.

Operator: Thank you. The next question is from the line of Derek Archila from Wells Fargo. Please go ahead.

Unidentified Analyst: Hey, guys. Good morning. This is [Yvonne] (ph) for Derek. Thanks for taking our question. So, a quick one from us, kind of like following up on the last question, on the STAT6 Phase 1 study, will you be including a cohort of patients to achieve this proof of concept, kind of like how you did with 474? Or will this only be including healthy volunteers? Thanks.

Nello Mainolfi: Well, at this point, I think all we said today was that the initial evaluation would be healthy volunteers. We’ll share more at a later date.

Unidentified Analyst: Okay, thanks.

Operator: Thank you. The next question is from the line of Divya Rao with TD Cowen & Company. Please go ahead.

Divya Rao: Hi, guys. This is Divya. I’m for Mark. Thanks for taking our question. Similar to the earlier question, what is the scope of kind of the disclosure that we should get from KT-333 at EHA? And then as a follow-up, I guess, what do you need to see in this Phase 1 trial, which I guess you’re planning on completing at the end of the year, and liquid tumors to continue development in both liquid and solid tumors?

Nello Mainolfi: I’ll take the second, and I’ll let Jared answer the first part of your question. So, the second part was around what do we need to see. So, as I said in the past also, our bar for continuing investment is having meaningful opportunity with a clear path to a sizable patient population with big clinical and commercial impact. And so, obviously, the more obvious answer to your question is that solid tumor opportunities would be able to make a much easier case for further investment. As I’ve said in the past, we don’t expect to see single-agent activity in solid tumor, as we haven’t seen preclinically. But we’re evaluating the biomarker — tumor biomarker effect to then tie it with preclinical data that we’ve already demonstrated in this potential solid tumor combo opportunity.

So, that is one. And then, obviously, having strong anti-tumor activity as a single-agent in liquid tumor is important for two reasons. One, because there are potential liquid tumor opportunities that are sizable enough to be interesting, but also to confirm that the drug is active and it’s worthwhile further investment in expanding the opportunity. Jared, do you want to comment a bit on the expectations for EHA?

Jared Gollob: Sure. If you recall that at ASH this past December, we presented data on 29 patients that we had enrolled so far. And we showed very encouraging safety data, which was allowing us to continue to dose escalate. We showed very strong pharmacodynamic data, including strong STAT3 knockdown in blood and tumor, as well as strong immunomodulatory effects in blood and tumor, such as that interferon gamma response that was predictive of potential combination with anti-PD-1. And we also showed these promising clinical responses in CTCL, as well as in Hodgkin’s lymphoma. So, the aim for the EHA presentation is really to build on that as we continue to dose escalate to provide further data around safety as we’ve been dose escalating, to provide additional pharmacologic data on target knockdown and immunomodulation in blood and whatever we may have in tumor, and to provide additional clinical response data.

Again, as you said, this is meant to be a clinical update, and then the plan will be then later in the year, once we anticipate completing dose escalation, to provide a final data set at a medical meeting later in 2024.

Divya Rao: Thank you.

Operator: Thank you. The next question is from the line of Thomas Smith from Leerink Partners. Please go ahead.

Nat Charoensook: Good morning. This is Nat Charoensook on for Thomas Smith. Thanks for taking the question. We have two, both in I&I. So, the first one is, what’s the getting factor to initiate a Phase 1 trial for KT-621, and what data can we expect from the readout in the first half of 2025 to help prioritize the indications for the subsequent development in I&I indications?

Nello Mainolfi: Okay, great. So, as we said on the call today and in the press release, so we’re in IND-enabling studies, and we’re going to leave it at that. We don’t usually provide a specific update on where exactly we are on the process. So, obviously completing that Phase 1 and IND and initiating Phase I is what’s between us and that. In terms of indication prioritization for STAT6, I think the only thing I would say is, as we said in the past also, we are focused on getting this drug to as many patients as possible, starting with large indications where we’ve seen injectables can really have low penetration for many, many reasons. So, I would say we’re prioritizing the larger indications, but that doesn’t mean we will not pursue others. I think that will happen, but just in a probably different stage in the manner.

Nat Charoensook: Got it. And for the IRAK4 program with data expected in the first half as well of next year, Sanofi will make the decision of going forward or not, but you also have an opt-in decision, like how are you approaching the opt-in and what do you need to see to make a decision?

Nello Mainolfi: Yes, so after Phase, 2 but before Phase 3. So, Phase 3 needs to be in the planning stage when we will have the opportunity to decide to opt-in or not. And the decision will be based on obvious reasons, the excitement we have around the opportunity with the drug, the investment that we have across our pipeline, the cash needs that will be needed across the investments across our pipeline. I would say, maybe naively, the best case is if the drug is as active as we expected it would be, it would be value accruing for us to opt-in, and so it would be probably an easy decision to make. But as you know, it’s hard to make decisions in a vacuum, so when we’re there, we will make the decisions based on all the other parameters I mentioned.

Operator: Thank you. The next question is from the line of Vikram Purohit from Morgan Stanley. Please go ahead.

Vikram Purohit: Hi, good morning. Thanks for taking our questions. So, we also had a couple of questions on 474. Apologies if you mentioned this in your prior Q&A and we missed it, but we were just curious on how you and Sanofi are currently thinking about indication expansion, 474, beyond HS and AD, and when some of those decisions could be made and how you’re thinking about them for the time being ahead of the HS and AD data sets coming in the first half of next year. And then secondly, on a more logistical point, should we hold the expectation that the HS and AD data sets would come together, or is that not necessarily the case? And if you have any visibility at this point on which venues or which forms might be appropriate to showcase those data sets, that would be a helpful color to get from your perspective? Thanks.

Nello Mainolfi: Thanks, Vikram. You got three questions in. Well done. So, let’s start with the last one. It’s hard for us to know, actually, both the timing and where. As the program’s timelines have been presented in clinicaltrials.gov with disclosures from both Sanofi and us, we’re seeing that both studies should be able to read out in the first half of 2025. I still feel we’re too early to know whether they’ll be disclosed together or separately. And so, give us more time. I think when we’re closer, we might be able to answer that question. In terms of the indication expansion, as I’ve said, in the past, we’ve Sanofi and Kymera have worked diligently on evaluating many other opportunities, many of these are obvious other indications that this biology has been validated in or known to be relevant.

I think there is sensitivity about disclosing what they are, just because I think the team right now is focused on executing on these studies. I believe Sanofi will be the one maybe disclosing other indications first, and then we’ll be happy to provide more colors. In terms of timing, again, I can’t speak for them, but let’s say for now we’re focused on executing on these studies. And I believe this is a personal opinion. As we get through some of these inflection points, we’ll be able to share more.

Vikram Purohit: Got it. Thank you.

Operator: Thank you. The next question is from the line of Geoff Meacham from Bank of America. Please go ahead.

Geoff Meacham: Hey, thank you. So, I guess I have a quick question on, given capital constraints, do you think that there’s a scenario where you guys might partner out some of your oncology assets? Like, what factors would you take into consideration when evaluating the potential for a partnership?

Nello Mainolfi: Yes, so thanks for the question. So, generally, as we’ve said we believe partnering is an option to continue to grow the company and need to serve a purpose. Rarely, rarely, not always, but rarely I would say that financials drive partnerships. But it has to be really financials only, right? There will have to be a win-win opportunity. I think it’s partnering in oncology is something that we’ve discussed in the past. It might be something that we’d be open to do for some of our oncology programs. I just can’t speak too specifically, given that we’re still in the midst of generating important data that will, first of all, tell us the level of commitment that Kymera on its own wants to invest in this program. I think after that we’ll be able to have a clearer view of what’s the best path for value creation for our oncology pipeline.

And it’s always partnership is a tool that any company should use to think about long-term value creation, as we can’t reinvent the wheel in every single program. Go ahead.

Geoff Meacham: Okay, great. And then, what are your BD priorities for this year?

Nello Mainolfi: Say that again? BD?

Geoff Meacham: Yes, Business Development.

Nello Mainolfi: Yes, I mean, I think I’ve answered that question already. Next question.

Operator: Thank you. The next question is from the line of Kelly Shi from Jefferies. Please go ahead.