So we also remain optimistic on a worldwide basis that Epidiolex can become cornerstone of therapy for this treatment-resistant epilepsy and be a blockbuster product for us.
Jason Gerberry: Great. Thanks, guys.
Operator: Please stand by for our next question. Our next question comes from David Amsellem with Piper Sandler. Your line is open.
David Amsellem: Hey, thanks. So two for me. One is, on the long-term targets, the 2025 goals, one of the things you talked about is margin expansion getting — I think, it was near 48% or close to 50% in 2025. And I’m wondering out loud, just particularly in the context of your nabiximols commentary, how much of that expansion is expense control and particularly R&D, just putting aside in process R&D, of course, but just organic R&D. How should we think about that, given that you’re at about, what, $490 million to $520 million in your guidance this year? So that’s number one. Number two is on Epidiolex, you talked about new prescriber growth. I’m just wondering, if you’re in a position to disclose how penetrated you are in your target audience? And what’s your general view regarding the pace of new prescriber growth as we move into and through 2023? Thanks.
Renée Galá: David, its Renée. I’ll take your first question in terms of margin expansion. So, certainly, we’ve been highly focused on operational excellence. And, yes, we have set out a 2025 adjusted operating margin ambition of being at 48%, in terms of the midpoint of our guidance today and my comments for the full year being in a position where we’re already at 49% for 2022. We’ve accomplished that through a number of areas. Of course, we said R&D was favorable, largely due to the nabiximols program decision as well as continued discipline. But as we look forward at what we’re trying to accomplish, ultimately, we’re looking to better leverage SG&A overall to be able to accommodate additional business development, to be able to accommodate additional investments in R&D in our pipeline.
And so, by being in the position that we are already, it gives us the opportunity to, between now and 2025, invest in our business, invest in the brands that we’re launching, the pipeline, our capabilities, continue to leverage that G&A footprint as our top line grows so that we can scale effectively and efficiently, and then still have the capacity to be active in future corporate development, which, of course, could result in additional commercial or R&D expenses. But we certainly have a commitment to continuing to expand our R&D pipeline. We now have enhanced capabilities across the pipeline coming out of our transaction with GW, and that’s an area we would expect over time, will continue to generate more value for patients and for shareholders.
And then I’ll turn it over to Dan to answer your second question.
Dan Swisher: Yes. Thanks, Renée. So on the Epidiolex, yes, we’re not giving specific penetration rates, but we had said in the past that Dravet is a little more penetrated because of the smaller indication. LGS and TSC, we see more opportunity. We also just see broadly that the drug works in a number of different seizure types and there’s many that make up these refractory populations that don’t have FDA-approved therapy. So then it’s a question of physician use and experience and market access. And that’s all going beneficially for us as well. There’s a lot of focus in terms of retention, and we’ve seen very strong retention. So when patients start the drug, they find this to be a very beneficial within a polypharmacy setting.
