Jazz Pharmaceuticals plc (NASDAQ:JAZZ) Q2 2023 Earnings Call Transcript

Jazz Pharmaceuticals plc (NASDAQ:JAZZ) Q2 2023 Earnings Call Transcript August 9, 2023

Jazz Pharmaceuticals plc beats earnings expectations. Reported EPS is $4.51, expectations were $4.46.

Operator: Good afternoon and thank you for attending the Jazz Pharmaceuticals Second Quarter 2023 Financial Results Call. My name is Elissa, and I will be your moderator for today’s call. All lines will be muted during the presentation portion of the call with an opportunity for questions and answers at the end. I would now like to pass the call over to the Jazz Pharmaceuticals team. You may proceed.

Andrea Flynn: Thank you, operator, and good afternoon, everyone. Today, Jazz Pharmaceuticals supported its second quarter 2023 financial results. The slide presentation accompanying this webcast is available on the Investors section of our website. Investors may also refer to the press release we issued earlier today, which is also posted to our website. On the call today are Bruce Cozadd, Chairman and Chief Executive Officer; Renee Gala, Executive Vice President and Chief Financial Officer; Dan Swisher, President and Chief Operating Officer; and Rob Iannone, Executive Vice President, Global Head of R&D; Kim Sablich, Executive Vice President and General Manager of United States, will join the team for Q&A. On Slide 2, I’d like to remind you that today’s webcast includes forward-looking statements, such as those related to our future financial and operating results, growth potential and anticipated development and commercialization milestones and goals which involve risks and uncertainties that could cause actual events, performance and results to differ materially from those contained in these forward-looking statements.

We encourage you to review the statements contained in today’s press release, in our slide deck and in our latest SEC disclosure documents, which identify certain factors that may cause the Company’s actual events, performance and results to differ materially from those contained in the forward-looking statements made on today’s webcast. We undertake no duty or obligation to update our forward-looking statements. Turning to Slide 3. On this webcast will discuss non-GAAP financial measures. Descriptions of these non-GAAP financial measures and reconciliations of GAAP to non-GAAP financial measures are included in today’s press release and the slide presentation available on the Investors section of our website. I’ll now turn the call over to Bruce.

Bruce Cozadd: Thanks, Andrea. Good afternoon, everyone, and thank you for joining us today. I’ll start on Slide 5. In the second quarter of 2023, we once again delivered strong commercial results, advanced our efforts to unlock the tremendous potential of our pipeline, and built on our record of driving operational excellence. In particular, our results in the second quarter highlight the durability and growth potential of our commercial portfolio, the capabilities and productivity of our R&D efforts, and our focus on operational excellence. We are pleased to report strong execution across our commercial portfolio with all three key growth drivers of our commercial business, Xywav, Epidiolex, Rylaze achieving year-over-year double-digit growth.

Xywav grew by 39% in the second quarter compared to the same period last year and is annualizing at well over $1 billion in revenue. Xywav Wave continues to be the oxybate of choice and the only approved therapy for idiopathic hypersomnia. We expect our oxybate franchise to contribute $2 billion of the $5 billion in total revenue component of Vision 2025 and are well positioned to reach this target. As a reminder, our 2023 neuroscience revenue guidance, which we are raising at the midpoint today and Vision 2025, both account for the availability of high sodium oxybate authorized generics or AGs and branded fixed dose high sodium oxybate. Epidiolex growth remains strong, and we are confident in its potential to reach blockbuster status. We achieved double-digit net sales growth in 2Q ’23 compared to the same period last year as we continued to drive prescriber growth across our global markets.

Our launch in Europe is gaining momentum, with additional international launches and indication expansions expected this year. In oncology, Rylaze has continued to grow in the U.S., underpinned by strong demand and our increasing emphasis on the adolescent and young adult market. Moving to our pipeline. Given the level of productivity in our R&D organization, I’m going to call out just a few items. Rob will cover our R&D progress in more detail later in the call. Our pipeline continues to advance towards meaningful catalysts with the potential for as many as four late-stage data readouts through 2024, the first being JZP150 late this year, followed by suvecaltamide and zanidatamab in GEA next year and top line PFS for Zepzelca in combination with Tecentriq, a in first-line extensive-stage small cell lung cancer at the end of 2024 or early 2025.

In addition to its strong commercial performance in the U.S., we are extremely pleased that we recently received a positive CHMP opinion on our marketing authorization application for JZP458 marketed as Rylaze in the U.S. and expect European Commission approval later this year. Since we added zanidatamab to our pipeline last year, it has continued to impress, and we’re excited by its broad applicability, which we believe represents $2 billion-plus in peak sales potential. Positive pivotal data from our Phase IIb trial in biliary tract cancers or BTC, were featured in an oral session at this year’s ASCO conference and concurrently published in the Lancet Oncology. These data were also selected for the best of ASCO meeting. top line data readout from the ongoing Phase III gastroesophageal adenocarcinoma, or GEA, trial is expected in 2024.

I’m also pleased to report that we recently received IND clearance for JZP898, an engineered interferon alpha cytokine prodrug that is activated specifically within the tumor micro environment where it can stimulate interferon alpha receptors on cancer-fighting immune effector cells. With this milestone achieved, we remain on track to initiate a Phase I trial of JZP898 later this year. On the operational side, we generated continued top and bottom line growth in the second quarter. Our commercial execution, coupled with our focus on operational excellence has put us in a strong financial position enabling us to execute a focused capital allocation strategy to invest in the products, pipeline programs and corporate development opportunities with the highest potential to deliver sustainable growth and enhanced value.

Given our financial strength and our current stock price, we have resumed share repurchases under our existing program, which Renee will expand upon shortly. Based on our performance in the first half of 2023 and expectations for the remainder of the year, we are raising our full year financial guidance for 2023. And longer term, we believe we are well positioned to achieve Vision 2025. Renee will provide additional commentary on our financials and guidance later in the call. Turning to Slide 6. We are excited about the progress we’ve achieved in the second quarter and believe it has substantially advanced us in all three areas of Vision 2025, and we are well positioned to achieve these important milestones in our transformation to a high-growth global biopharma leader.

I’ll now turn the call over to Dan to review our commercial performance, after which Rob will share an update on our R&D progress, Renee will provide a financial overview, and then we’ll open the call to Q&A. Dan?

Dan Swisher: Thanks, Bruce. I’m excited to provide an update on our commercial progress. Starting on Slide 8, with neuroscience and oxybate, we remain confident in the strength and durability of our oxybate franchise as Xywav continues to be the oxybate choice and the only approved therapy for IH. Xywav revenues were $327 million for the second quarter of 2023 and representing growth of 39% compared to the same period in 2022. I’ll note, this growth was against the backdrop of high sodium oxybate competition entering the market in January of this year. In narcolepsy, our focus remains on educating patients and prescribers on the benefits of reducing sodium intake and this message continues to resonate. In addition to health benefits of liver sodium, based on our discussions with health care professionals and experienced oxybate patients dosing flexibility to value attribute to Xywav.

Exiting the second quarter, approximately 9,300 narcolepsy patients were taking Xywav, and Xywav continues to be the oxybated choice in the marketplace. In IH, we see continued growth of new prescribers with approximately 2,200 patients taking Xywav for treatment of IH exiting the second quarter. IH is a 24-hour sleep disorder despite sleeping a normal or longer than normal and ultimate type people with IH may still experience debilitating symptoms during the day. Xywav is the first and only treatment approved by FDA to treat the full condition of IH. We are focused on educating prescribers on the importance of proper diagnosis and identifying appropriate patients who can benefit from Xywav therapy. And a survey of sleep specialists indicated that 70% anticipate increasing their prescribing in the next six months.

With regard to the average number of patients on Xywav exiting the quarter, there was an operational change in our specialty pharmacy, which caused delays in getting refills on time for some Xywav patients. This is being addressed and importantly, overall second quarter Xywav HCP and patient demands were in line with our expectations in prior quarters. As Renee will review in more detail, we have raised our neuroscience revenue guidance at the midpoint reflecting our continued confidence in the growth opportunity for Xywav wave and the durability of oxybate. Total revenues for the combined oxybate business, including royalties from a high sodium oxybate a decreased 2% to $492 million in the second quarter compared to the same period in 2022.

There were approximately 16,200 total average active Jazz oxybate patients in the second quarter, a decrease compared to the end of the first quarter, primarily reflecting the expected impact of Xyrem as a result of the availability of a high sodium oxybate AG. Our focus is on continuing to grow low study and Xywav across both narcolepsy and IH, and we are pleased with Xywav’s growth across both indications even as additional high sodium oxybate competition is available for patients with narcolepsy. The continued growth of Xywav is one of the factors that contributed to our increased 2023 neuroscience revenue guidance. And as Bruce mentioned, we are well positioned to achieve our Vision 2025 target of $2 billion in revenue from our oxybate franchise.

Slide 9 highlights the compelling low sodium and health benefits we are sharing with health care professionals and patients. As narcolepsy is a debilitating chronic condition we have focused on educational efforts around the lifelong burden of high sodium intake for narcolepsy patients who live with a 2x to 3x higher risk than the general population of cardiovascular comorbidities such as stroke and heart failure. Xywav is the only approved low sodium oxybate and the only oxybate without a label warning about high sodium intake as 92% less sodium than high studying oxydates. The American Heart Association recommends a maximum of 1,500 milligrams of sodium per day. While high sodium AGs and branded oxybate of 1,100 to 1,640 milligrams of sodium, Xywav has only 100 to 140 milligrams, a reduction of 1,000 to 1,500 milligrams of sodium per day.

To put this in perspective, it would take 12 years of treatment with Xywav to equal the sodium intake of one: year of high sodium oxybate treatment. This has significant potential health benefits, including lower blood pressure and improved cardiovascular health. To add to the literature on sodium impact, we presented data at this year’s American Academy of Neurology Meeting that showed narcolepsy patients treated with high sodium oxybate at a higher risk of new onset hypertension diagnosis or anti-hypertensive medication initiation within 180 days of starting therapy when compared to a matched control group of narcolepsy patients not being treated with high sodium oxybate. In fact, the risk of those taking high sodium oxybate was approximately twice that of the control group.

We believe these data highlight that sodium intake is a health concern for all narcolepsy patients and one that can have near-term consequences. FDA has recognized that the difference in sodium content between Xywav and high sodium oxybate, including Xyrem, AG Xyrem and LUMRYZ is likely to be clinically meaningful in all patients with narcolepsy and that Xywav is safer in all such patients. LUMRYZ is a recently launched branded fixed-dose high-sodium oxybate that has the same sodium content as Xyrem. We believe that the majority of patients and health care providers will continue to prioritize long-term health when evaluating oxybate therapy. With respect to competition from high sodium oxybate authorized generics or AGs, Amneal announced the launch of their AG in early July.

Two additional companies, Lupin and Par also have rights to launch AG products. At this time, Par and Lupin have elected not to launch. These three AG suppliers are each restricted to a low single-digit percentage of Xyrem sales volume. As a reminder, earlier this year, Hikma launched the volume unlimited AG. Jazz receives meaningful royalties on all high sodium oxybate AGs. Moving to Slide 10. We remain confident in the blockbuster potential of Epidiolex with yet another quarter of double-digit year-over-year revenue growth. Net product sales increased 15% to $202 million in the second quarter compared to the same period in 2022, driven by underlying demand. We have seen increased penetration in the long-term care setting, driven by additional in-person engagement with physicians, and we have additional opportunities for growth.

Turning to Slide 11. We are focused on multiple opportunities to drive Epidiolex to blockbuster status. We continue to see a positive impact from our educational efforts focused on optimal dosing and caregiver reported outcomes beyond seizure control from the become survey, which further differentiates Epidiolex from other anti-seizure medicines. In particular, reports from the field indicates that the become data has been very impactful with both HCPs and caregivers. The compelling clinical data regarding the use of Epidiolex in combination with clobazam versus using the agents individually continues to resonate. Our commercial team also has an enhanced focus on further penetration into the adult setting. We are also pleased our commercialization efforts outside the U.S. continue to gain momentum.

Slide 12 illustrates our progress in expanding Epidiolex outside of the U.S. Epidiolex is now launched and reimbursed in 23 countries around the world, including all five key European markets. While it’s early, we are very encouraged by initial uptake in these markets with favorable pricing and access. We anticipate additional reimbursement decisions and submissions through this year and next. Moving to our oncology franchise beginning on Slide 13. Net product sales for Rylaze were $102 million for the second quarter, a 39% increase year-over-year in our fourth consecutive quarter of growth. We continue to see strong demand for Rylaze, reflecting the significant unmet patient need for a high-quality, reliable supply of erwinia asparaginase for patients with acute lymphoblastic leukemia.

Based on the availability of Rylaze, health care professionals have indicated they are returning the best clinical practice in switching therapy at the first signs of hypersensitivity. We continue to receive positive feedback from health care providers about the adoption of the Monday, Wednesday, Friday dosing regimen, which allows a dosing schedule that is more in line with preferred clinical practice. Rylaze has been almost universally adopted in pediatric oncology protocols, and we are encouraged to see that there is increasing use of Rylaze in the treatment of adolescents and young adults or the AYA market, which is an area of increased emphasis for us in 2023. Outside of the U.S., we recently received a positive CHMP opinion. With the positive opinion granted, we anticipate EC approval of our MAA submission later this year.

Regarding the market opportunity, I’ll note that there is competition in many European markets. Jazz has consistently delivered a reliable, high-quality supply of this important therapy in the U.S., and we are excited for patients and health care providers in Europe to have the opportunity to complete their full course of asparaginase therapy. Turning to Slide 14. We rapidly established Zepzelca as a treatment of choice in second-line small cell lung cancer. Net product sales increased 3% to $70 million in the second quarter compared to the same period in 2022. We have achieved significant penetration in the second line setting, but there remains significant unmet need for patients diagnosed with small cell lung cancer with five-year overall survival rates of less than 10% and median overall survival of 6 to 24 months depending on the stage of diagnosis.

Given this prognosis, there is a further opportunity to both improve patient lives and drive growth through our pivotal Phase III trial in first-line small cell lung cancer in combination with Tecentriq. We expect top line PFS data readout at the end of 2024 or early 2025. In the U.S., there are approximately 27,000 first-line small cell lung cancer patients treated annually. Zepzelca has the potential to increase the duration of response with these earlier-stage patients. With that, I’ll turn it over to Rob for an update on our pipeline and upcoming milestones. Rob?

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Rob Iannone: Thanks, Dan. Starting on Slide 16. We provided an overview of the key clinical programs in our diversified pipeline. We are excited about the advances we’ve made so far this year with the potential for as many as four late-stage data readouts through 2023 and 2024, which include JZP150 in PTSD, suvecaltamide in essential tremor, zanidatamab in GEA and Zepzelca in combination with Tecentriq in first-line small cell lung cancer. I’ll discuss a few of our programs in more detail shortly, but I wanted to broadly highlight our progress across the pipeline before moving on. Starting with neuroscience. We expect top line data from our Phase II trial of JZP150 in PTSD by the end of the year. For JZP441, our Orexin-2 receptor agonist that has the potential to treat narcolepsy, IH and other sleep disorders, we anticipate initial proof of concept in healthy volunteers later this year.

In addition, we have ongoing trials for suvecaltamide in both essential tremor or ET and Parkinson’s disease tremor, with top line data from the ET trial expected in the first half of 2024. Moving to oncology. Zanidatamab is a priority program for us. We aim to advance Zanidatamab to the market as rapidly as possible with second-line BPC representing our first potential commercial indication. We are planning for a potential accelerated approval of Zanidatamab in second-line BTC and have aligned it with the FDA on a confirmatory trial in first-line metastatic BTC where there remain unmet patient needs. We are also evaluating Zanidatamab in GEA, breast cancer and other HER2-positive solid tumors. For Zepzelca, we expect top line PFS data readout at the end of 2024 or early 2025.

Small cell lung cancer patients have particularly poor outcomes, with a five-year overall survival rate of less than 10%. Currently, Zepzelca’s indicated to treat patients in the second-line setting, but we see a clear mechanistic rationale or Zepzelca to potentially benefit more patients and increase the duration of response in the first line setting as maintenance therapy in combination with the standard of care. Beyond small cell lung cancer, we have elected to close our Phase II basket trial based on limited responses in three solid tumor cohorts. We’re analyzing the findings from that trial and continue to explore additional tumor types that may benefit from treatment with Zepzelca. As Dan and Bruce mentioned earlier, we are very pleased that received a positive CHMP opinion on JZP458, which is marketed as Rylaze in the U.S. With Monday, Wednesday, Friday, at every 48-hour dosing regimens, as well as IV and IM administration.

We anticipate EC approval later this year. Moving to Slide 17. The I’ll expand on my earlier comments regarding Zanidatamab. Zanidatamab is a novel bispecific antibody that can simultaneously bind two non-overlapping epitopes of HER2, known as biparatopic binding. This unique design results in multiple mechanisms of action including dual HER2 signal blockade, receptor clustering on the cell surface, leading to internalization biparatopic binding and potent effector functions, including antibody-dependent cellulose cytotoxicity, antibody-dependent cellular phagocytosis and complement-dependent cytotoxicity leading to encouraging antitumor activity in patients. Zanidatamab has shown compelling activity across a broad range of HER2-positive tumors and we presented promising efficacy and early survival data at both ASCO and ASCO GI this year.

Additional data presentations are planned for later this year, including quality of life outcomes from the HERIZON-BTC-01 pivotal study at the European Society of Medical Oncology annual Congress. This slide speaks to our development strategy presenting, which is focused on four key areas: First, target areas no approved HER2 agents, such as the significant unmet need second-line HER2-positive BTC as well as other solid tumors. Second, maximize the opportunity in GEA and other HER2-positive tumors, where we believe Zanidatamab has the potential to be the HER2-targeted treatment of choice, simpleminded HER2-targeted agents. Compelling data demonstrated that Zanidatamab has the potential to be a foundational treatment for patients with HER2-positive GEA.

Third, we see substantial opportunity in setting tower Zanidatamab could be used in combination with standard of care for other novel therapies, particularly in breast cancer and in earlier lines of treatment. Fourth, we plan to build upon the compelling activity we’ve seen across a broad range of HER2-positive tumors to address the patient need in additional tumor types. We believe this approach will allow us to deliver an important new therapeutic option to patients and maximize the value of Zanidatamab. On Slide 18, I want to provide more insight into our excitement about the long-term potential of Zanidatamab, which we believe could go beyond addressing significant unmet needs in BTC and GEA include breast cancer as well as multiple additional cancers that over express HER2.

With the potential to transform the current standard of care in multiple HER2-positive cancers, we are committed to rapidly advancing and expanding our development program. We believe that Zanidatamab has the opportunity to be a differentiated bispecific treatment of choice for HER2-positive cancers. We expect to enter the market first in second-line BTC where physicians will gain important experience with Zanidatamab. The approach is supported by recent compelling data presented at ASCO in previously treated HER2 positive BTC. We are pleased to share that we are planning for a potential accelerated approval zanidatamab and second-line BTC based on the HERIZON-BTC-01 data, and are working to rapidly bring this therapy to patients in critical need.

We’ve shared the impressive second-line data with the FDA can have alignment on a confirmatory trial in first-line metastatic BTC where there remains an important unmet patient need. We are continuing to work with FDA regarding time lines and as our conversations progress. We will expect to be able to provide further updates. Following market entry in BTC, we expect to have a path to approval in first-line GEA with a supplemental BLA submission, which provides a more streamlined approval process compared to a full BLA. With the treatment landscape evolving following recent data readouts, we continue to strongly believe that substantial opportunity remains to address the unmet patient need in first-line GEA, including the HER2-positive PD-L1 negative patient population where the standard of care remains trastuzumab plus chemotherapy.

For patients who are PD-L1 positive, we continue to believe that Zanidatamab has the potential to be a HER2-targeted treatment of choice, while also combining with BeiGene, tislelizumab in order to treat those who are eligible to receive anti-PD-1 therapy GEA. Further, there remains an opportunity to move into earlier stages of GEA, where we see the potential to help those patients prior to the metastatic setting in the neoadjuvant and adjuvant settings. GEA represents a significantly larger patient opportunity compared to BTC. And a prior approval in BC may also accelerate adoption into GEA treatment guidelines and protocols. We look forward to additional data from the ongoing pivotal Phase III GA trial HERIZON-GEA-01 expected to read out in 2024, which may support U.S. 10 global regulatory submissions.

Breast cancer also represents a considerable opportunity,x supported by promising early data as monotherapy in multiple combinations across lines of therapy. Based on the efficacy and safety seen in studies to date, we believe Zanidatamab is well suited for early-stage disease, including potential use of neoadjuvant and adjuvant therapy. Further, we believe there is potential to help patients previously treated with trastuzumab deruxtecan or TDXD or for those patients who are ineligible to receive treatment with TDXD. Zanidatamab has also shown promise in HER2-positive and hormone receptor positive breast cancer as part of a novel combination. Supporting this, we have ongoing trials in neoadjuvant breast cancer and the opportunity to expand into both combination regimens and later lines of therapy and HER2-positive and HER2 HR-positive breast cancer.

We are also evaluating Zanidatamab through multiple earlier stage trials in other tumor types, where few HER2-targeted treatment options are available. Zanidatamab has shown clinical activity across a diverse set of HER2-positive indications such as colorectal cancer, non-small cell lung cancer and multiple other cancers where there remain a few targeted treatment options available to the patients. Turning to Slide 19. I would like to highlight JZP150, our novel, highly selective fatty acid amide hydrolase or FAAH inhibitor, is currently in clinical development for the potential treatment of PTSD with Phase II top line data expected later this year. PTSD is a psychiatric disorder that affect millions of people and patients frequently have uncontrolled symptoms that impact their ability to perform activities of daily living and function socially.

Only two antidepressants have received approval from FDA for the treatment of PTSD symptoms in the past 20 years. Current first-line pharmacological treatment for PTSD such as selective serotonin reuptake inhibitors mitigate some symptoms of PTSD that are not designed to address the core underlying problem, peer extension learning and its consolidation. Response rates to existing pharmacological treatments rarely exceed 60% and even fewer patients achieved clinical remission. We have been granted FDA Fast Track designation for JZP150, underscoring the significant unmet needs of PTSD patients. JZP150 is a once-daily oral medication that has the potential to impact the pathophysiology and symptoms of PTSD. Data to-date have demonstrated benefits with for extension and stress response in healthy volunteers.

Slide 20 shows the PTSD pathophysiology and JZP150 mechanism of action and treatment rationale. PTSD can result from direct or indirect exposure the traumatic experience as an event. Individuals with PTSD have intense and disturbing thoughts and feelings related to their experience that persist long after their dramatic event and they may relive the event through flashback or nightmares and feel sadness, fear, anger and detachment from other people. In PTSD, fear extinction deficits contribute to the persistence of traumatic memories, interventions to promote fear extinction learning or foundation of PTSD treatment. Preclinical and clinical data indicates that exposure to stress and anxiety is associated with activation of fatty acid amide hydrolase or FAAH.

Inhibition of FAAH has the potential to directly target pathophysiological processes of PTSD. FAAH is the enzyme responsible for the degradation of anandamide. Anandamide is reduced in PTSD and failure of anandamide to return to normal levels can result in a number of behavioral conditions underlying PTSD, including increased anxiety and impaired extinction processing of emotional memory. Inhibition of FAAH results and an increase in anandomide. This has been shown to reduce anxiety, improved fear extinction and recall and improve sleep architecture and self-reported sleep quality. JZP150 is a potent, highly selective and irreversible inhibitor of FAAH designed to address the underlying cause of PTSD. Moving to Slide 21. We have outlined the design of the Phase II PTSD trial.

The primary endpoint of the trial is change in total symptom severity score using the clinician-administered PTSD scale or CAPS-5 from baseline to the end of treatment. CAPS-5 is a structured 30-item clinical interview as a validated instrument considered the standard for diagnosing and assessing patients with PTSD and is an endpoint that has been determined to be appropriate for regulatory purposes. Beyond PTSD diagnosis, it also allows physicians to evaluate the severity of symptoms an impact on social and occupational function. The trial has several secondary endpoints, including changes in scores on clinical global impression of severity in the patient global impression of severity scales from baseline to the treatment. The ongoing trial is enrolling approximately 270 patients and assessing two doses of JZP150 compared to placebo, which we believe adequately powers the trial to assess whether JZP150 is clinically meaningful in this patient population.

We expect top line data by the end of this year. We are excited about the potential of JZP150 and look forward to updating you on our progress. Turning to Slide 22. I we are pleased to recently receive IND clearance for JZP898 and expect to initiate a Phase I trial later this year. JZP898 is an engineered interferon alpha cytokine pro drop that is activated specifically within the tumor microenvironment where it can stimulate interferon alpha receptors on cancer fighting immune effector cells. High-dose interferon alpha therapy is approved in multiple tumor types, but is used sparingly based on its toxicity profile. Systemic delivery of cytokines can cause serious toxicities and peripheral tissues. This leads to poor clinical outcomes of an ineffective antitumor immune activation and unmanageable toxicity in patients.

JZP898 is conditionally activated interferon alpha which is selectively activated in the tumor microenvironment. Through this approach, biologically relevant exposures are coupled with optimal cytokine potency while limiting toxicity and other tissues. We are excited to bring this novel molecule into the clinic later this year. Overall, our R&D team continues to advance multiple programs from our neurosciences and oncology pipelines, and we’re looking forward to multiple near-term data readouts. Now, I will turn over the call to Renee for a financial update. Renee?

Renee Gala: Thanks, Rob. I’ll start with our top and bottom line results on Slide 24. As a reminder, our full financial results are available in our press release and 10-Q. In the second quarter of 2023, we achieved $957 million in total revenues. This was driven by growth of our key products in both neuroscience and oncology, including another quarter of double-digit growth of Xywav, Epidiolex and Rylaze compared to 2Q ’22. We’re particularly pleased with the continued trajectory of Xywav even with competition since the beginning of the year, coupled with the continued Epidiolex momentum and strong growth for Rylaze, we saw total revenue increased 3% compared to 2Q ’22. Our disciplined capital allocation and focus on operational excellence drove adjusted net income of $325 million growth of 6% compared to the same quarter in 2022.

We continue to generate significant cash from our business, recording approximately $617 million of cash from operations in the first half of 2023, an increase of more than $100 million compared to the same period in 2022. Our strong overall financial position means we have significant flexibility to invest in priority commercial and R&D programs as well as corporate development opportunities. Corporate development is a core component of Vision 2025, and we remain active in exploring opportunities to expand our commercial portfolio and pipeline. Turning to Slide 25. We are updating our total 2023 revenue guidance to a range of $3.725 billion to $3.875 billion, reflecting a $25 million increase at the midpoint. This update is underpinned by an increase of $20 million at the midpoint of our neuroscience revenue guidance.

Our increased 2023 neuroscience revenue guidance incorporates our continued confidence in the durability of our oxybate franchise in part based on the performance and growth of Xywav during the first half of the year, a time period in which we saw the introduction of high sodium oxybate competition. With regard to high sodium authorized generics, we expect our royalties from Hikma, which is the only volume unlimited authorized generic to be significantly higher in the second half of 2023 relative to the first half. During the second half of 2023, the royalty rate from Hikma to Jazz becomes fixed at a rate where we and Hikma both have substantial economics. We also received royalties on other high sodium oxybate AGs, all of which are restricted to a low single-digit percentage of Xyrem sales volume.

As Dan noted earlier, currently, only one additional AG has been launched. Our 2023 oncology guidance remains unchanged and reflects expectations of continued double-digit growth for this franchise led by Rylaze with a revenue range of $950 million to $1.05 billion and a midpoint of $1 billion. Continuing to Slide 26. Our capital allocation strategy includes investment in commercial brands to drive top line growth in our pipeline to drive long-term growth and in corporate development where we remain actively engaged in assessing opportunities and which remains an important pillar of our growth strategy. We are maintaining our prior non-GAAP SG&A and R&D guidance for 2023. Consistent with our capital allocation strategy, our enhanced investment in R&D is a direct result of our success in diversifying and advancing our pipeline as well as prioritizing those programs that we believe will have the biggest impact for patients while delivering value and contributing to our growth.

We believe there is tremendous unrecognized value potential in our stock and therefore, supported by our strong cash flows and aligned to our strategic and disciplined approach to capital allocation, we have resumed share repurchases under our existing repurchase program. In the second quarter, we completed approximately $100 million of share repurchases. As of the end of the second quarter, approximately $336 million remained available for share repurchases under our current plan. Importantly, given our strong overall financial position, we are able to repurchase shares without compromising our ability to execute business development opportunities and invest in our innovative R&D program. On the bottom line, we expect to continue to deliver strong adjusted net income, or ANI, and have increased our non-GAAP ANI guidance to $1.29 billion to $1.34 billion, which implies a 41% year-over-year ANI growth at the midpoint.

I would also like to highlight, we raised our non-GAAP adjusted EPS guidance to a range of $185 to $19 and an increase of $1.20 at the midpoint, primarily driven by our increased revenue and ANI outlook as well as reductions in our fully diluted shares outstanding. The decrease to our weighted average ordinary share guidance relates to both our share repurchase and to our recent irrevocable election to settle in cash the principal of our $575 million exchangeable senior notes due in 2024, thereby limiting potential dilution from these instruments. With our strategic investments, expanding product portfolio, R&D progress and focus on operational excellence, we believe we are well positioned to achieve Vision 2025 and deliver further diversification, sustainable growth and enhanced value to patients and shareholders.

I’d now like to turn the call back to Bruce.

Bruce Cozadd: Thanks, Renee. I’ll conclude our prepared remarks on Slide 28. The first half of 2023 has been driven by focused execution and strong commercial results, evidenced by the durability of our oxybate franchise continued growth of Epidiolex and strength in Rylaze sales. We continue to advance our pipeline and invest in long-term growth, and we have as many as four late-stage data readouts through 2024 and that have the potential to further diversify and transform our business. Our latest pipeline addition, Zanidatamab is approaching several near-term clinical and regulatory milestones. Given its applicability across multiple tumor types and lines of therapy, we believe Zanidatamab has $2 billion-plus in peak sales potential.

We also remain focused on strategic capital allocation. With our strong cash flow, balance sheet and margins, we have the financial flexibility to make significant investments across commercial, pipeline and corporate development to drive sustainable growth and enhance value. That concludes our prepared remarks. I’d now like to turn the call over to the operator to open the line for Q&A.

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Q&A Session

Operator: We will now begin the Q&A session. [Operator Instructions] The first question comes from the line of Jason Gerberry with Bank of America. Your line is now open.

Jason Gerberry: Mine is on the Phase III Zani GEA study that’s going to read out first half next year. Can you help frame what sort of data we can expect on the primary efficacy measures, the PFS OS? Is this a first interim? I’m just wondering if PFS and OS will be mature or the focus really is on ORR in this data cut?

Bruce Cozadd: Rob, maybe I’ll throw that one to you.

Rob Iannone: So just to clarify, what we said previously was in 2024, we didn’t specify exactly when. And in that, we are referring to PFS as the initial readout. Does that clarify your question?

Operator: The next question comes from the line of Joseph Thome with TD Cowen. Your line is now open.

Joseph Thome: Maybe one on the upcoming PTSD readout. Maybe what’s a clinically meaningful benefit on that cap scale? And when you talk about the type of patients enrolled or the on concomitant SSRI or the SRI treatment failures? Can you just put that in context a little bit for us? That would be great.

Bruce Cozadd: Yes. Go ahead, Rob.

Rob Iannone: Sure. So, we haven’t said specifically what treatment effect that we’ve powered to, but you could draw some of your own inferences by looking at the sample sizes, et cetera, that’s listed on ct.gov. And you’ll note that it’s a placebo-controlled trial with two dose levels in the total sample size. Patients are allowed other concomitant medications.

Operator: Thank you. The next question comes from the line of Marc Goodman with Leerink Partners. Your line is now open.

Marc Goodman: Could you please give us a little more color on the comment that you made regarding the operational issues with the specialty pharmacy and the oxybate franchise and just give us a sense of how much you think it may have impacted patients in the quarter or whatever you think it may have impacted or is it impacting anything in the third quarter?

Bruce Cozadd: Kim, you want to take that?

Kim Sablich: Sure. I’d be happy to. So let me start out by saying that we continue to be very confident in the strength and durability of our activate franchise as low sodium Xywav continues to be the activate of choice and the only approved therapy for IH. The decrease in total average active Jazz oxybate patients this quarter primarily reflects the expected impact to Xyrem as a result of Xywav adoption and the availability of AG Xyrem. In terms of Xywav and the average number of patients on Xywav exiting the quarter there was what we’re calling an operational change at our specialty pharmacy, which unfortunately caused delays in some Xywav patients getting their refills on time. So this has been addressed. And importantly, I think to understand is that the overall 2Q Xywav HCP and patient demand, the overall market demand for Xywav was in line with our expectations and with what we saw in prior quarters.

So this really was an issue at the pharmacy that affected patients. Some patients getting refills, not with the overall demand for Xywav. The benefits of reducing sodium intake in the market continue to resonate with our customers, and we’re very confident in the growth opportunity for Xywav and the durability of the franchise. And while we expect Xyrem to continue to decline in line with the Xywav and AG adoption, as you heard, we’ve raised our full year 2023 financial guidance. and increase our neuroscience revenue guidance at the midpoint. So overall, our increased neuroscience revenue guidance accounts for the performance and growth of Xywav during the first half of the year in the time period in which we saw the introduction of high sodium oxybate competition.

So our focus remains on continuing to grow the low sodium Xywav, which is already, as you saw annualizing at well over $1 billion, and we remain very confident in the durability of the business.