Is Arrowhead Pharmaceuticals (ARWR) Still a Great Investment Pick?

Baron Funds, an asset management firm, published its “Baron Health Care Fund” third quarter 2021 investor letter – a copy of which can be downloaded here. A return of 1.18% was delivered by the fund’s institutional shares for the third quarter of 2021, outperforming both its S&P 500 and Russell 3000 Health Care benchmarks that delivered 0.58% and 0.17% returns respectively for the same period. You can take a look at the fund’s top 5 holdings to have an idea about their best picks for 2021.

Baron Funds, in its Q3 2021 investor letter, mentioned Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) and discussed its stance on the firm. Arrowhead Pharmaceuticals, Inc. is a Pasadena, California-based biopharmaceutical company with an $8.4 billion market capitalization. ARWR delivered a 5.21% return since the beginning of the year, while its 12-month returns are up by 21.49%. The stock closed at $80.73 per share on November 5, 2021.

Here is what Baron Funds has to say about Arrowhead Pharmaceuticals, Inc. in its Q3 2021 investor letter:

Arrowhead Pharmaceuticals, Inc. is a biotechnology company developing RNAi (i=interference) drugs. Shares dropped after a July announcement that the company was pausing its early stage clinical trial for a treatment for cystic fibrosis. A few weeks after the July announcement, the company presented positive data for a treatment targeting a protein in kidney cancer. We retain conviction in Arrowhead and the long-term prospects of RNAi as a drug category.”

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Based on our calculations, Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) was not able to clinch a spot in our list of the 30 Most Popular Stocks Among Hedge Funds. ARWR was in 30 hedge fund portfolios at the end of the first half of 2021, compared to 20 funds in the previous quarter. Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) delivered a 24.60% return in the past 3 months.

Hedge funds’ reputation as shrewd investors has been tarnished in the last decade as their hedged returns couldn’t keep up with the unhedged returns of the market indices. Our research has shown that hedge funds’ small-cap stock picks managed to beat the market by double digits annually between 1999 and 2016, but the margin of outperformance has been declining in recent years. Nevertheless, we were still able to identify in advance a select group of hedge fund holdings that outperformed the S&P 500 ETFs by 115 percentage points since March 2017 (see the details here). We were also able to identify in advance a select group of hedge fund holdings that underperformed the market by 10 percentage points annually between 2006 and 2017. Interestingly the margin of underperformance of these stocks has been increasing in recent years. Investors who are long the market and short these stocks would have returned more than 27% annually between 2015 and 2017. We have been tracking and sharing the list of these stocks since February 2017 in our quarterly newsletter.

At Insider Monkey, we scour multiple sources to uncover the next great investment idea. For example, billionaire John Paulson is loading up on the miners, so we are checking out stock pitches like this mining stock. We go through lists like the 10 best EV stocks to pick the next Tesla that will deliver a 10x return. Even though we recommend positions in only a tiny fraction of the companies we analyze, we check out as many stocks as we can. We read hedge fund investor letters and listen to stock pitches at hedge fund conferences. You can subscribe to our free daily newsletter on our homepage.

Disclosure: None. This article is originally published at Insider Monkey.