Brett Monia: Sure, James. There was a lot there, especially in the second part of your question, we can talk about, but I’ll try to be brief. So Angelman will be brief because we don’t have anything more to report at this time, except that we feel very good. We feel very confident in the execution of the study. It’s going very well. Biogen has not laid out a time line for data dissemination from the Phase I/II study. We are working through the potential efficacy endpoints that would support a Phase III study now. We are making great progress with regulators as to what would constitute a clinically meaningful benefit end point for patients with Angelman syndrome for a potential Phase III start. I have to leave it at that right now.
Hopefully, Biogen will provide an update later this year. But we’re very — feeling very good about the Angelman study. With respect to monetization, what we partner, what we keep and so forth, I’ll take a stab with that maybe then Onaiza could chip in a little bit, too. So today, we have a wealth of assets that are in front of us for Ionis from our R&D organization. We focus on the late-stage pipeline. We have a really rich mid-stage pipeline as well as a lot of new drugs coming into development right now. And we are very carefully deciding on as we did recently with eplontersen, olezarsen and donidalorsen which of those assets make sense for Ionis to keep and to bring to the market ourselves. And we’re looking forward versus those that we think will be — will do better, will be better off with a potential partner down the road.
We’re looking forward to providing an update on what I referred to as the next wave of Ionis commercial opportunities in the second half of this year beyond eplontersen, olezarsen and donidalorsen. Right now, we’re laser-focused on launching those drugs. As far as monetization goes, I think you asked, we’re not planning — there are no plans to do any royalty work at the royalty monetization like we did for pelacarsen in SPINRAZA earlier this year Royalty pharma. But do you want to talk a little bit about prioritization and how we go through that.
Onaiza Cadoret: Yes, sure. I think you covered mist of it, maybe I think I’ll give you a lens into the second half of the year. as we focused on these 3 near-term commercial opportunities, we’re also looking from a line of sight as to what comes next in the mid-stage pipeline. And we look at a lot of factors. I think Brett mentioned a couple. We have in the time frame within which they would be on market, can we maximize the full potential of the product. If we can, then does that actually fit with some of the kind of customer-facing synergies that we see. And if they don’t, can we actually do it in a very efficient way. So that’s probably a bit of our schematic over here in terms of criteria to make those selections. We see a really nice cadence of products coming in from the neurology franchise.
