Mara Goldstein : So firstly, on the covered prescription rate, you mentioned you anticipate about 20% free drug. So that would indicate you’re at 70% covered at this point in time or 71%. How quickly do you expect to get to that incremental difference? And is it consistent among vitiligo and atopic dermatitis? And secondarily, can you talk a little bit about the expectations for the rollout of RUX QD and how we should think about how that will affect Jakafi?
Barry Flannelly : Sure. So Mara, this is Barry. So the covered rate — actually, the commercial patients that have access to commercial drug through their insurance is about 84% right now. In terms of coverage beyond that, it’s about 90%. But obviously, these numbers don’t match up because there’s a lag in getting utilization criteria written and so forth. But we’re very happy with the coverage that has happened thus far. We’re very happy with, for example, Medicaid coverage, which is covered in all 50 states. And like I said, the commercial insurance continues to get better and better. We still have some work to do and improving a variety of things, including co-pay and utilization criteria that might not be exactly where we want it to be.
In terms of AD and vitiligo, the coverage is essentially the same. The commercial coverage is essentially the same. The Medicaid, VA, DoD coverage is essentially the same. The only thing about vitiligo is there’s some less, but it’s improving every day. The number of utilization criteria that have been written related to Opzelura and vitiligo. But I have to say, compared to when we launched atopic dermatitis, the number of issues, problems with getting vitiligo scripts filled is very, very low. In fact, we don’t hear that much about it at all. In terms of RUX QD, I think we mentioned already that the PDUFA date comes in March. We plan on launching sometime after that, a few weeks after that in April. And when we announce the approval, we’ll give you some more information about how we’re going to roll this out, the positioning and so forth of RUX QD.
But we’re very excited about the upcoming launch. We think it really gives an opportunity for better convenience for patients, which could lead to better compliance for patients; and at least for some patients, better compliance could lead to better outcomes. So we’re really looking forward to that.
Operator: Next question is coming from Ren Benjamin from JMP Securities.
Reni Benjamin : Thanks for taking the questions and congratulations on a great quarter. Just looking at the GVHD market, can you talk a little bit about the split between chronic versus acute? And how is the drug being used, especially in comparison to, let’s say, ibrutinib. And I guess I’m curious, where does axa kind of fit into this program, especially after the pivotal data expected in mid ’23? And if I can just squeeze one extra one. Can you just give us some thoughts on tafa and what the — how you’re thinking about the reduced expectations for 2023, at least in the U.S?
Barry Flannelly : Sure. This is Barry. So in terms of the split between acute and chronic, there’s about 1,500 patients in steroid-refractory acute GVHD. As I said before, we’re the #1 drug used there in steroid-refractory acute GVHD. But there’s much less patients and they’re treated for a shorter period of time. So it might be, for example, six months for acute GVHD. For chronic GVHD, there’s 14,000 patients, maybe 7,500 that are steroid-refractory. So most of the growth is coming from chronic GVHD and the persistence in chronic GVHD. Now most of the time, the claims that would come in don’t really differentiate between acute and chronic. But as far as we can tell, the vast majority of scripts that are coming in now are all for chronic GVHD.
