David Berman: Yes. Michael, so the association with survival we have validated in uveal melanoma in two independent trials. So when it comes to uveal melanoma, ctDNA, we have really strong confidence. With cutaneous melanoma, as we have emerging confidence, but we, of course, don’t have randomized trials, and we don’t have long-term survival. So we will be looking both at ctDNA directionally, as an early potential surrogate, and we’ll be looking at survival in parallel. We hope that this trial will begin to set up the associations that we have seen in uveal in cutaneous melanoma. But we acknowledge that we’ll need to see both ctDNA and survival and integrate both of those at this early time.
Operator: Thank you. Our next question comes from the line of Ahu Demir with Ladenburg. Please proceed with your question.
Ahu Demir: Good morning, thank you so much for taking my questions and congrats on the quarter. Two questions from us. First one is on the PRAME melanoma readout in the second quarter. In terms of the patient follow-up, could you give us a sense of the majority of patients, how long they were followed-up for? And the second question I have is expectation for the HIV med study. What does success look like?
Bahija Jallal: Thank you, Ahu. David and maybe Mohammed as well.
David Berman: Yes. In terms of the PRAME melanoma, I do think we have sufficient follow-up in order to show durability. I don’t have the exact follow-up with me right now, but I would say Ahu, that it’s going to be sufficient in order to interpret the data. And that’s because — and the reason I say is because we enrolled a lot of those patients throughout 2023. In terms of HIV, it’s a good question because no one has ever been able to show a reduction in the reservoir or a functional cure. So for the reduction of the reservoir, we’ll be looking in the blood to see whether we can reduce CD4 T cells with HIV. And in terms of what success looks like that, I think we’re going to have to generate the data, share it with the KOLs and then we’ll share that data and we’ll be able to interpret what success looks like.
In terms of a delay of survival rebound, that also is a very novel. No one has been able to show that. So I think we’re going to have to look at the data, discuss with KOLs and then we’ll share the data. I think any sign of the delay in rebound that we can attribute biologically to the drug would be a success as an initial step in HIV treatment.
Operator: Thank you. Our next question comes from the line of Rajan Sharma with Goldman Sachs. Please proceed with your question.
Rajan Sharma: Hi, just a quick one on KIMMTRAK and just kind of thinking about how confident you are in maintaining pricing in a scenario where you do get these additional settings that you’ve talked to which obviously potentially significantly increase the number of aids on therapy. I think this time you flagged 6,000 potential patients versus 1,000 currently. So I’d be keen to understand how you see that playing out.
Bahija Jallal: Hi Rajan, thank you. No, I think it would be a good problem to have, but go ahead Ralph.
Ralph Torbay: I agree. Thank you for the question. So look, the way we look at pricing is really the PRAME that we use is the value that it brings to patients, value that it brings to society. So as Bahija said, it’s a little bit early for us to comment on that. So once we see the data, we hope that this is bringing significant value. Therefore, the price erosion would be minimal.
Operator: Thank you. There are no further questions at this time. I would now like to hand the call back over to Bahija Jallal for any closing remarks.
Bahija Jallal: Thank you very much. So, in closing, I would like to express really my gratitude to our patients, to our shareholders and to the team. This past year has been a testament to our drive to bring contract to patients, our innovation into bringing more novel targets and entering a new therapeutic area, and as always, our commitment to patients by working with sense of urgency. And as we move forward into the next fiscal year, we remain steadfast in our mission to drive growth, create value and deliver results. I would like to end this call by thanking all of you for your support. Thank you.
Operator: Thank you. That does conclude today’s teleconference. We appreciate your participation. You may disconnect your lines at this time. Enjoy the rest of your day.
