Operator: Thank you. Our next question comes from the line of Justin Zelin with BTIG. Please proceed with your question.
Justin Zelin: Thanks for taking the question. Maybe for David, can you just walk us through – obviously, you’re moving forward PRAME here in the first line versus KIMMTRAK in – and second and third in cutaneous melanoma. Can you just walk us through just the numbers for the accessible market for gp100 versus PRAME and cutaneous.
David Berman: Yes, Justin. So the current Phase 2/3 study TEBE-AM and KIMMTRAK, we estimate to be 2,000 to 4,000 patients per year, and that patients have progressed on ipilimumab and BRAF-targeted therapy and anti-PD-1s. For PRAME in first-line, part of the reason we’re so excited about this, the opportunity is greater than 10,000 patients per year. That’s the difference in terms of size.
Operator: Thank you. Our next question comes from the line of Graig Suvannavejh with Mizuho. Please proceed with your question.
Graig Suvannavejh: Thank you and good morning. Congrats on the progress from me as well. A lot of questions on PRAME, but I would just want to focus on KIMMTRAK and the cutaneous melanoma opportunity. Well, actually, uveal, I know that there’s been developments on the competitive landscape, and I know that there are thoughts around potentially combining KIMMTRAK with PRAME. So can you just give us your overall strategy there in uveal melanoma? Thanks so much.
David Berman: Yes, I’m happy to take that and invite anyone else to join also. So KIMMTRAK had a great survival benefit and there’s a lot of patients who benefit. We are really excited about our combination of KIMMTRAK plus PRAME. It’s – we’re currently doing the dose escalation optimization. They’re both very active drugs and the idea there would be to study KIMMTRAK plus PRAME in the first-line setting. So once we have that data available and we can have a good regimen, we’ll be able to share that data.
Operator: Thank you. Our next question comes from the line of Justin Kim with Oppenheimer. Please proceed with your question.
Justin Kim: Hi. Good morning and thanks for taking the question. Maybe just to pivot a little bit to the HIV program. We’re hearing a lot more interest in sort of the program as we see potential data near term. Can you just frame for us how we should expect the initial data cut to look? And what exactly is the expectation for patients who withdraw ART over a 12-week time frame?
Bahija Jallal: Thanks. David, you are –
David Berman: Yes, I’m happy to take that. So in terms of the data, we were doing the multiple ascending dose where we treat patients for 12 weeks with intra-patient escalation and then at a target dose. We expect to have multiple cohorts completed, multiple-dose escalations completed when we share the data. The data will include, of course, safety and biomarkers during the initial 12-week run in. After 12 weeks, we will interrupt both our bispecific as well as the antiretroviral therapy, and there we’ll look for a rebound of the virus. Historically, I think the virus will rebound usually within a few weeks. I think most of the patients usually rebound within four weeks. We have a 12-week planned interruption. And so, in terms of what we’re looking for there, it’s a new field. I mean no one has ever really had a functional care in HIV. So we’re really excited to see where this data leads us.
Operator: Thank you. Our next question comes from the line of Michael Schmidt with Guggenheim. Please proceed with your question.
