Illumina, Inc. (NASDAQ:ILMN) Q1 2024 Earnings Call Transcript

Illumina, Inc. (NASDAQ:ILMN) Q1 2024 Earnings Call Transcript May 2, 2024

Illumina, Inc. misses on earnings expectations. Reported EPS is $-0.79245 EPS, expectations were $0.03. Illumina, Inc. isn’t one of the 30 most popular stocks among hedge funds at the end of the third quarter (see the details here).

Operator: Good day, ladies and gentlemen, and welcome to the First Quarter 2024 Illumina Earnings Conference Call. At this time, all participants are in a listen-only mode. After the speakers’ presentation, there will be a question-and-answer session. Please be advised that today’s conference is being recorded. I would now like to hand the conference over to Salli Schwartz, Vice President of Investor Relations.

Salli Schwartz: Hello, everyone, and welcome to our earnings call for the first quarter of 2024. During the call today, we will review the financial results we released after the close of market and offer commentary on our commercial and regulatory activity, after which we will host a question-and-answer session. Our earnings release can be found in the Investor Relations section of our website at illumina.com. Providing prepared remarks for Illumina today will be Jacob Thaysen, Chief Executive Officer; and Ankur Dhingra, Chief Financial Officer. Jacob will provide an update on the state of Illumina’s business and Ankur will review our financial results, which include GRAIL. Joydeep Goswami who is serving as an advisor to the company through June 30 will then join us for Q&A.

As a reminder, GRAIL must be held and operated separately and independently from Illumina, pursuant to the transitional measures ordered by the European Commission, which prohibited our acquisition of GRAIL under the EU merger regulation. This call is being recorded and the audio portion will be archived in the Investors section of our website. It is our intent that all forward-looking statements regarding our financial results and commercial activity made during today’s call will be protected under the Private Securities Litigation Reform Act of 1995. Forward-looking statements are subject to risks and uncertainties. Actual events or results may differ materially from those projected or discussed. All forward-looking statements are based upon current available information, and Illumina assumes no obligation to update these statements.

To better understand the risks and uncertainties that could cause actual results to differ, we refer you to the documents that Illumina files with the Securities and Exchange Commission including Illumina’s most recent Forms 10-Q and 10-K. With that, I’ll now turn the call over to Jacob.

Jacob Thaysen: Thank you, Salli. Good afternoon, everyone. Before going into our first quarter results, I want to take a moment to thank our former Chief Financial Officer, and Chief Strategy and Corporate Development Officer, Joydeep Goswami, for his many contributions to Illumina over more than four years. As Salli noted, Joydeep will stay on an advisory role through June to support a smooth transition. I also wanted to welcome our new CFO, Ankur Dhingra, who you will hear from shortly, and congratulate Jakob Wedel, who has now been named as Chief Strategy and Corporate Development Officer. Jakob joined Illumina in November and has been heavily involved in our long-term strategy planning. Throughout the quarter, I continued to meet with customers around the world and had the opportunity to bring a number of them to our San Diego headquarters to discuss new ways to collaborate, innovate, and shape what their future looks like with Illumina.

Some of our customers shared how they are scaling up their projects with NovaSeq X to unlock greater discovery power. One key area of focus is harnessing whole genome opportunities in minimal residual disease. Other customers are starting to sequence deeper and are adding multiomics layers to their projects, while others are looking at epigenomic biomarkers and methylation to help diagnose and characterize disease. We are seeing a significant opportunity to expand in multiomics. Customers are looking for more sophisticated solutions to support their work, and we are exploring all avenues to create value in this space. Our recent acquisition of Partek, a specialized multiomics software solution, is a building block of our expansion into this space.

Our intent is to collaborate with our customers to understand how we can provide more sample to answer solutions. Illumina is at the heart of the ecosystem and we will continue to catalyze the industry with an even greater focus on our customers’ priorities. Turning to our first quarter results, I’ll focus my comments on Core Illumina. In Q1, we delivered Core Illumina revenue of approximately $1.06 billion ahead of our expectations. While it was a decent start to the year, we remain cautious due to the persistently challenging global macro environment where customers are still constrained in their purchasing decisions. As expected, we are seeing this playing out across our regions, notably with lower NovaSeq X placements versus the first quarter of 2023, where we shipped our first X instrument to fulfill a strong pre-order book.

Three of our regions declined year-over-year. America’s revenue was down 4%. EMEA revenue was down 3%. And Greater China revenue was down 14%. Europe revenue was up 7% year-over-year although we expect a decline in Q2 given the last year’s strong X shipment in Europe in the second quarter. Nonetheless, Illumina management team continues to make significant progress executing against my three key priorities to accelerate value creation across the company. My first priority, driving our top line, is grounded in a growing installed base and helping customers realize the full potential of our instruments. In Q1, we shipped an additional 55 NovaSeq X instruments, bringing our total X installed base to more than 400 instruments. This is a solid start of the year and we expect momentum to continue to build.

We also saw promising consumables demand throughout the quarter as our customers continue to scaling their operations and expand their sequencing projects. With the launch of the 25B Reagent Kit in Q4 and the 1.5B in Q1, and alongside with the well-received upgrade of the 10B flow cell, we are now providing our customers with the full suite of NovoSeq X products. In Q1, we also made XLEAP-SBS chemistry available to our mid-throughput customers with the launch of our P4 flow cell on the existing NextSeq 1K, 2K instruments. In the first several weeks post-launch, we have received exceptional feedback from customers who are reporting reads that exceed specs for quantity and quality. Customers are positive about the simple migration that’s enabled them to run spatial and single-cell projects, and they are impressed with the accuracy they see with the dragon on board.

Illumina continues to pursue strategic partnership and alliances to drive the entire genomics ecosystem forward. As a recent example, Pillar Biosciences announced FDA approval for its pan-cancer IVD for general tumor profiling on the Illumina MiSeq DX system. We’ve been partner with Pillar since 2017 and are excited for this important milestone. Also in the quarter, Bristol Myers Squibb joined our previously announced collaboration with Johnson & Johnson Innovative Medicine on the development of our multi-cancer whole genome sequencing based molecular residual disease assay to better understand disease recurrence. You should expect to see more of these types of activities going forward. Now turning to my second priority. I’m continuing my focus on delivering operational excellence by driving margin improvement through increased productivity by sustaining innovation and growth.

It has been my goal to align our organization in a way that best supports our customers’ evolving needs. In March, we brought together our marketing and commercial teams under one customer first global function. I’m confident that combining these teams into one global commercial organization will build our agility to better serve customers, while delivering more sustained growth and margins over time. Additionally, we are focused on driving further improvements throughout our end-to-end supply chain and are taking a disciplined approach to improve our cost structure. In Q1, we implemented new initiatives to adjust pricing across our portfolio to better cover our global operational cost. We also made progress in streamlining our real estate footprint as we exited select facilities in the Bay Area and in San Diego.

These actions add to the number of ongoing initiatives that will continue to support our margins and increase further flexibility for investment in high growth areas. We are also tightly focused on stabilizing our Greater China business. And in Q1, we brought on Jenny Zheng as Head of Region. Jenny has deep expertise in healthcare and global organization and a strong leadership and execution mindset. She’s already proving to be a great leader of our China team and is introducing changes to make our business more in China for China, which will include improving our local manufacturing and partnerships in the region. Moving on to my third priority, which is working to resolve GRAIL as quickly as possible. In April, we reached an important milestone in the divestment process when the European Commission approved our divestment plan for GRAIL.

The approved plan contemplates both sales and capital markets options and we have made progress on both paths, consistent with the European Commission’s divestiture. In the event of a capital market transaction, we are required to capitalize GRAIL with approximately $1 billion, reflecting two and a half years of funding based on GRAIL’s long-range plan. The amount includes cash on GRAIL’s balance sheet. We are on track to finalize the terms of the transactions by the end of the second quarter. I look forward to having additional updates for you soon. Overall, I’m encouraged by the progress we have achieved in the quarter and optimistic about delivering on our initiatives here in 2024. Now I’ll ask Ankur to share more detail on our first quarter results and outlook.

Ankur Dhingra: Thank you, Jacob. And hello, everyone. I’m very excited to join Team Illumina to improve human health by unlocking the power of the genome. I’m passionate about making a positive, meaningful impact in health care. I am very familiar with the role Illumina has played in establishing and advancing the genomics industry over the last 25 years. Building on that strong foundation, I’m confident we can continue leading, supporting our customers, and delivering on the promise of what genomics can do for patients around the globe. I would also like to express my thanks to Joydeep for his support as I transition into my role. It’s been a great first two and a half weeks. I’ll start by reviewing our segment results for Core Illumina and GRAIL, followed by consolidated financial results, and then conclude with my remarks on our current outlook for 2024.

I will be discussing non-GAAP results, which include stock-based compensation. I encourage you to review the GAAP reconciliation of these non-GAAP measures which can be found in today’s release and in the supplementary data available on our website. Starting with our segment financials. Core Illumina first quarter revenue was $1.06 billion dollars, which is down 2% year-on-year, both on a reported and constant currency basis. This revenue performance exceeded our expectations and was primarily driven by three areas. First, strong performance in high throughput consumables. Second, timing of revenue from certain strategic partnerships. And third, some customers accelerating delivery of a few NovaSeq X instruments from Q2 into Q1. Core Illumina sequencing consumables revenue of $698 million was up 1% year-over-year, primarily due to growth in high throughput.

On a sequential basis, NovaSeq X consumables grew in the double digits following the successful launch of the 25B flow cell. Total sequencing GB output on our connected high and mid-throughput instruments grew over 35% year-over-year and grew at a high single digit rate quarter-over-quarter. The research and applied activity benefited as transition to the NovaSeq X continues to ramp and 25B adoption grew at large core labs. Clinical activity continued to be driven predominantly by the NovoSeq 6000. As a reminder, we believe this data is a useful reference that shows the general activity trends across our install base and is directionally correlated with revenue over time. Sequencing instruments revenue for Core Illumina of $110 million declined 29% year-over-year in Q1 2024.

The year-over-year decline was driven both by, one, an expected decline in mid-through-put shipments as capital and cash flow constraints continue to impact purchasing behavior and moderate instrument placements, and second, lower NovaSeq X placements as compared to significant pre-order launch-related shipments in the first quarter of 2023. For NovaSeq X, as Jacob noted, we shipped 55 instruments in Q1. Core Illumina sequencing service and other revenue of $151 million was up 27% year-over-year, driven primarily by an increase in revenue from strategic partnerships and higher instrument service contract revenue on a growing install base. Moving to the rest of the Core Illumina P&L. Core Illumina non-GAAP gross margin of 67.1% for the quarter increased 190 basis points year-over-year, driven primarily by a more favorable mix of sequencing consumables and execution of our operational excellence priorities that delivered cost savings, including freight and improved productivity.

This was partially offset by certain strategic partnership revenue, that is lower margin, and increased warranty and fuel service cost. Core Illumina non-GAAP operating expenses of $491 million were down $23 million year-over-year, primarily due to decreased labor expense as a result of reduced headcount and continued savings from our cost containment initiatives. Core Illumina non-GAAP operating expenses were lower than expected due to timing of project spend shifting from Q1 into Q2 and lower stock-based compensation expense due to one-time reversals. Putting it all together, Core Illumina non-GAAP operating margin was 20.6% in Q1 2024 compared to 17.4% in Q1 2023. Transitioning to financial results for GRAIL. GRAIL revenue of $27 million for the quarter grew 35% year-over-year, driven primarily by adoption of Galleri.

GRAIL non-GAAP operating expenses totaled $197 million and increased $24 million year-over-year, driven primarily by increased headcount to support commercial expansion and research and development. Moving to consolidated financial results. In the first quarter, consolidated revenue of $1.08 billion was down 1% year-over-year, both on a reported and constant currency basis. Non-GAAP net income was $14 million or $0.09 per diluted share, which included dilution from GRAIL’s non-GAAP operating loss of $185 million for the quarter. Non-GAAP EPS exceeded our expectations, driven primarily by higher core revenue and lower core operating expenses in the quarter. Our Q1 non-GAAP tax rate was 46.4% compared to 27.3% in Q1 2023, with both periods including a meaningful impact from the consolidations of GRAIL’s operating loss, which increased by $21 million year-over-year.

Absent the impact of GRAIL, our Q1 2024 and Q1 2023 tax rates were in the mid-20s. Our non-GAAP weighted average diluted share count for the quarter was approximately 159 million. Moving to consolidated cash flow and balance sheet items for the quarter. Cash flow provided by operations were $77 million. Capital expenditures were $36 million and free cash flow was $41 million and we did not repurchase any common stock. We ended the quarter with approximately $1.12 billion in cash, cash equivalents and short-term investments. Moving now to 2024 guidance. As a reminder, Illumina is moving as quickly as possible to resolve GRAIL, and the company is focusing its 2024 financial outlook on Core Illumina, given the uncertainty around the specific timing and impact of the GRAIL divestment.

Our guidance does not assume any impact from the potential divestment of GRAIL in 2024. We will provide non-GAAP EPS guidance for 2024 upon completion of the divestment. We are encouraged by our results in Q1 that came in ahead of our expectations, both for top line and margins. We’ve also seen the seasonal rebuild of our total performance obligations, our backlog, which increased more than 20% from the end of Q4. At the same time, we’re still not seeing any significant improvement in the macroeconomic environment or our business in China. And we are monitoring the impact of a strengthening US dollar. While we are seeing early strength in consumables to start the year, it’s being offset by capital constraints that are continuing to weigh on instrument purchases.

As such, we are reiterating our full year 2024 Core Illumina revenue guidance of approximately flat from 2023, and non-GAAP operating margin of approximately 20%. Our operating margin expectations continue to reflect the benefit of gross margin improvement and disciplined management of our expenses, including reduced headcount, offset by normalization of our performance-based compensation, as well as the impacts of inflation. For the second quarter of 2024, we expect Core Illumina revenue in the range of $1.072 billion to $1.084 billion, reflecting a year-over-year decline of 6.5 to 7.5 percentage points. The year-over-year decline is predominantly because of the lower NovaSeq X instrument shipments, given the significant backlog we worked through early last year following the launch.

At the midpoint, this guidance reflects a $22 million sequential increase from Q1 of 2024. For the second quarter, we expect Core Illumina non-GAAP operating margin of approximately 18%, resulting from a seasonal step up in operating expenses in Q2 compared to Q1, primarily due to an increase in stock-based compensation expenses from the timing of equity grants. We also expect an increase due to some project spending shifting into Q2 from Q1. With that, I will now turn it back over to Jacob for his closing remarks. Thank you.

Jacob Thaysen: Thanks, Ankur. Before we close and move to Q&A, I’d like to comment on our upcoming strategy update event. Illumina’s leadership team has been reexamining our strategy, the roadmap and initiatives for achieving it, and the profitable growth we believe it can produce. Our strategy will continue to play to Illumina strength of building the genomics ecosystem and maintaining a tight customer focus in an increasingly competitive space. Central to this is our goal of making customers the heroes in their labs. In every customer meeting we are listening intently to understand what they need to unleash the full power of their Illumina instruments and making their priorities the core of our strategy. You will see us continue to develop more sample-to-answer solutions to enable the genomics and multiomics ecosystem.

We’ll maintain our open platform approach and continue to drive the innovation that our customers need to succeed and for which Illumina is known. Illumina has long been the standard at NGS. Our strategic, hands-on support for customers globally, our deep experience and expertise across multiple research and clinical markets, and our decade-long technology roadmap position us well to continuing leading the industry and enabling our customers to improve human health. I am excited to announce that we will be sharing our comprehensive strategy work with you during a virtual event in the fall of this year. We will have more information in the coming month. Thank you for joining. I’ll now invite Ankur and Joydeep to join me for Q&A.

Operator: Thank you. [Operator Instructions] Our first question comes from the line of Doug Schenkel with Wolfe Research.

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Q&A Session

Doug Schenkel: Hey, good afternoon and thank you for taking my question. Jacob, I want to start with a high level one that kind of builds off of the announcement you just made, and then I want to ask a specific cleanup question on the quarter. So first, it’s hard to believe, but we’re now just over, I think it’s eight months into your tenure as CEO of the company. From the outside we see the changes you are starting to make to leadership, to the broader organization, and in moving towards a resolution on GRAIL. That said, there continues to be a lot of uncertainty about things like, first, I’d say your view on Illumina’s long-term growth profile, especially given uncertainty about the competitive landscape and the outlook for market elasticity.

Secondly, what are reasonable operational targets? And then thirdly, ultimately, whether the company as we sit here today is positioned to play offense. Would you be willing to share at least a little bit more today about where you are in the process of moving from data gathering and business assessment to maybe putting some stakes in the ground regarding the medium and long-term outlook for the company from a growth and operating margin standpoint? And I know that was a lot, but let me let me sneak in the mathematical follow up question on the quarter. It seems like high throughput sequencing consumable revenue grew low to mid teens. Is that right? And if so, what does that tell you about evolving competitive dynamics and questions regarding elasticity?

Thank you.

Jacob Thaysen: Well, Doug, thank you very much. That was a long question and I think also happy birthday to you. So I’ll do my best here to answer the first question. And I think actually I’m just a little bit over seven months into my tenure. So maybe I should have them another month before we ask this question. But definitely I’m spending — I continue to spend a lot of time with our customers, with our employees. I’m excited every time I go and walk over in the R&D building and uncover new innovations that we are doing. There’s a lot going on in this company. And in the meantime, we are also spending a lot of energy on looking into, of course, where — how are we — in what direction are we footing Illumina going forward?

And I think we covered a little bit then in my prepared remarks is that we see a lot of opportunities in — both in genomics now with the X coming out there and we see a lot of elasticity in that area already with many customers are using that to go into single cell, into spatial and doing bigger and bigger program and deeper and deeper analysis. This is not something that is in the future. It’s already happening now but, obviously, at the same time we’re running through that change in price point and, of course, we expect to see elasticity to really help us here over the next period of time. So while I’m not ready to share with you where we would go from an overall growth perspective, long range, I can guarantee you that we still are optimistic about the growth of Illumina going forward.

Secondly, as I think you saw here in Q1, we are highly dedicated to continue to expand our margins. And I’m really pleased with what all the work that went into with the team here and how we saw the gross margin expansion here for the quarter. So, I think that’s just an evidence on what we are committed to do to continue to drive up. And I don’t think there’s anything that holds us back to drive up margins over the next period of time to where we have been in historic levels. But then again, I do want to wait a little more to have everything lined up from a strategic point of view and thereby also our growth algorithm and our cost structure algorithm to really go out and share the details. But fundamentally, I truly believe that Illumina has a great opportunity of being and continuing to what we have done the last decade of leading the genomics industry, being in the middle of the ecosystem, really go out there and support our customers.

But now in the future, where the customer expectations are aren’t different from what they have been in the past, to really focus on end-to-end workflows, but also new innovations into the multiomics space that we highly committed to. So that was where I’m right now. I think then maybe — yes, on — Joydeep can help us a little bit on the consumable question.

Joydeep Goswami: Yes, look, I think — hey, happy birthday again, Doug. On consumables, we — as expected, saw strong growth with X consumables. And we saw X consumable revenues offset, or growth in X consumables revenues offset the expected decline in 6K consumers, right? So that’s a good piece. We also are seeing very strong sequencing activity growth driven by X and X customers, right? So this is a really positive thing and it underpins a lot of what Jacob talked about in terms of new applications or expanded applications in clinical and in research, right? So we’re excited about that and we expect that to continue as the 25B flow cell gets more adopted and more used in regular activities that are customers.

Operator: Thank you. The next question comes from the line of Puneet Souda with Leerink Partners.

Puneet Souda: Hi guys, thanks for taking my questions. Let me focus a bit on the mid-throughput segment. I just want to understand, can you provide us what was the growth in that mid-throughput segment for both consumables and more importantly, instrumentation? There are increasingly more questions as customers in the core labs that don’t necessarily have an X or a 6K are taking on a competitor system because it’s lower price, I mean, or lower cost per gigabase, almost half of what XLEAP is in the next week. So just wondering, can you elaborate a bit more on what’s happening in that segment? And how do you address that? Thank you.

Jacob Thaysen: Yes, thanks for that, Puneet. I think as a starting point, we are not providing details on the growth on the mid-throughput segment, but let me just try to address some of your questions anyway is that, we, of course, are very committed to the mid-throughput, and I’m really excited with the XLEAP’s chemistry now coming out on the 1K/2K. It’s only been a few weeks out there but we have seen, as I mentioned also before, tremendous excitement from our customers that this doesn’t need a new instrument you can pretty much with a software upgrade, you can add — you can use new flow cells and you can get higher quality scores, you can get more capacity and you can also, of course, with a low price point. So a lot of our customers are super excited about that and it really makes us highly competitive in that space.

That said, you’re right, there is competition and by the way, we take competition very seriously in our whole segment but mid-throughput is clearly aware that there’s more activity — competitive activities than maybe other spaces. We are seeing that mostly in China still, but in the rest of the world there’s also that. But we will continue to innovate in this space. I think the XLEAP, as I mentioned, was a good step in that direction. But it’s an area we will continue to compete in and also we expect to fight for every market share points out there.

Joydeep Goswami: Maybe to add, right. So two things we continue to see consumables growth, so elasticity in that mid-throughput segment so that’s one. And two, we had as we had told you when we set our budget for the year, we had already anticipated a certain level of competition and what we’re seeing in the market is in line with what we had expected. And again, I want to emphasize that some of the forecasts that we had given from mid-throughput accounted for the macroeconomic headwinds that we had expected to see going through this year. And we — actually, those have come to bear, right? So again, it’s in line with what we had told you.

Operator: Thank you. Your next question comes from the line of Vijay Kumar with Evercore ISI.

Vijay Kumar: Hey, guys. Thanks for taking my question. Ankur, welcome. I guess my first question is on the guidance here. And, Jacob, maybe you can chime in on this, right? So, sequentially, core revenues are up by about $30 million-ish. Is that all being driven by consumables? I think you mentioned you saw improving consumable pull through on the X throughout the quarter as the quarter progressed. So, maybe some color on what the exit rate is and where is that increase coming from?

Jacob Thaysen: Yes, I think Ankur can certainly also chime in here, but we saw actually strengths throughout the quarter. There was nothing of this being the last few weeks of the quarter, but we continue to see customers adopt the X consumables. Now where we have a full portfolio of both the 25B, the 10B, and the 1.5B, we see a lot of more applications coming on from our customers. So it has really been truly by the X, as Joydeep also was talking about before, that we have seen improvement. Besides that, we have also — so the beat was very nice on the consumers, but we’ve also seen our BD revenue grow. We have seen some partnerships that has been accelerated and we’re just excited about that because it’s a big part of our strategy also to continue to develop together with our partners. So that was also part of our performance. Ankur, you have more…

Ankur Dhingra: Yes, I think that was well covered. The only thing I would add specifically that the sequential increase in business that we’re forecasting and built in the guidance comes both from instruments and consumables. So we’re expecting both of that positive trend to continue.

Operator: Thank you. Your next question comes from the line of Dan Brennan with TD Cowen.

Dan Brennan: Great, thank you, Ankur. Welcome aboard. Maybe just a question on multiomics and some of the new products that, Jacob, you’ve been talking about and it’s been kind of in the Illumina proxy as well. Can you just give us some color, maybe start with maybe the SomaLogic kind of partnership? Is that the multiomic excitement that you’re expressing? And then any other color you could provide about like sample-to-answer and some of the newer areas that you’re looking to explore timing-wise, when do you think we’ll get an update on that? Will it be on Investor Day? Or just how do we think about potential opportunity for Illumina? Thank you.

Jacob Thaysen: Yes, for sure. Thanks, Dan. And you’re absolutely right. I mean, overall, I’m excited about the way that sequences can play in multiomics. And I’m excited about what — how we can help also partners and customers stimulate that market. And that goes for all the multiomic spaces, if you look into them. But of course, we are — if you just look short term here, we’re, of course, very excited about our relationship with SomaLogic and where we can go with the proteomics. We are still in early access. So ’24 will be the year where we are going out with a few handfuls of customers and really going in and make sure we truly understand the power, but already the feedback from customers so far has been very positive on that.

So I’m certainly excited about that. But we will continue to look into options for us to play even stronger into multiomics going forward across all the opportunities there, both organically, but of course, also together with our partners out there. If you look into end-to-end workflows, I think that’s really a great opportunity, as I mentioned also before, that I see customers obviously, are looking for the best technology, but they’re also looking for ease of use. That is not only about the sequence itself, but sample-to-answer. And the more we can automate, the more we can simplify both from, of course, sample prep, but of course, also from informatics, I think we can really make sure that our customers can spend the time on where they can create most value.

So we’ll speak more about that, as you mentioned also in our strategy update. And I think Illumina has a great opportunity to cover whole workflows and create great applications for our customers.

Operator: Thank you. Your next question comes from the line of Daniel Arias with Stifel.

Unidentified Analyst: Hey, guys. This is Paul on for Dan. Thanks for the questions. I think just one from us. In terms of [POPSEQ] (ph), could we get some commentary on that? It seems like all of us has seen some budget pressure. There’s been some news flow there with recent cuts. Does that create any risk to the consumables forecast for the year? And maybe on the flip side, in Europe with genome of Europe, there’s been some chatter about that picking up? Is that something you could see increased activity in 2025 that would be meaningful?

Jacob Thaysen: I think overall, we have — if you look at the longer run, we are — long horizon or midterm horizon. I’m very excited about the PopGen — not only for PopGen but what it really constitute in terms of [indiscernible] really looking into big genomic studies to — in the end to implement into the health care system. And we have more than 30 programs ongoing right now, and we have at least the same number in the funnel for opportunities for the future. But we’re not banking on any one individual program. So it’s clear with these big programs, where you have sovereigns have to make the systems and budgets and so on that there’s a little bit puts and takes in that. And thereby, we are not really budgeting and building our budgets based on individual programs. So I don’t foresee that any of them are making a big impact on our either 2024, 2025 opportunity. But obviously, we are doing our best to stimulate the market out there.

Operator: Thank you. Your next question comes from the line of David Westenberg with Piper Sandler.

David Westenberg: Great. Thank you for taking the questions. So I just want to start with the continuation of Puneet’s question on the mid-throughput side. How has XLEAP helped maybe in that mid-throughput — or how do you anticipate it helping it. And Joydeep, I think you mentioned some — there is some elasticity there. I think there, it’s a little bit less clear in the X department, you definitely see the whole genome from exome, you see a lot more single cell kind of stuff. Can you just reiterate some of that elasticity and how to prevent that from being a race to the bottom, just given that the — as you mentioned, the competitor is using price there? And then on the high throughput side, you did say that you expect the order rate momentum to build. Is that based on actual orders in the book? Is it very late in the cycle orders or it’s just anticipation of budgets? I mean, any way you can walk us through how — make us a little more clear on that? Thank you.

Jacob Thaysen: Yes. No, thanks. Let me try to give a little more color on the mid-throughput is that we’re actually seeing with — XLEAP’s chemistry is — as I said, there’s really two dimension to it is high quality of sequencing, but it’s also higher capacity with a lower cost. So it really gives customers an opportunity to do more with the sequences. And thereby, we also see that there are customers that were looking to maybe go into single cell or even spatial that they felt they couldn’t afford or they couldn’t do on — with the capacities or with the cost positioning that was previously that now opens up for that space. So I think we are seeing again an elasticity game that will play out over the next period of time. I think in the end, customers are really looking to work with innovators here in the field.

And they — I think XLEAP chemistry is just another example that we continue to innovate in all our segments. And so while it is an environment right now that’s also been impacted by the macro, I actually am pretty excited about what the XLEAP chemistry will do for us over the next period of time and what new applications it will bring on also in the mid throughput. As you mentioned, there are a lot of things going on in high throughput also but we see some of the same things happening in mid-throughput.

Joydeep Goswami: Yes. I think I think just to comment on and add to what Jacob has said, right? XLEAP, remember, was a way for us to help our customers use the same instruments that are already out in the field and with a simple software change, right, they basically can get increased output, better accuracy, better performance. And I think we saw that come through very clearly with our launch in Q1. I want to emphasize too, right? You’re seeing the elasticity and really immediately in the research domain, right, where a lot of what Jacob was talking about in terms of multiomics, single cell, spatial things do tend to get performed first on the research side on mid-throughput. We are also continuing to see that we can maintain, because of our innovation and our technical superiority, a price premium over what others are offering in the market, right?

So we’re seeing a lot of that continue, and we are encouraged by that. The macroeconomic pieces are there, but they will end at some point, and we do expect that at that point, some of the cash constraints that our customers are facing will lift.

Jacob Thaysen: Yes. And then I think you had the question about how orders on the X. And I would say, first of all, the — we’ve seen the X orders being up year-over-year. So we’re certainly encouraged by that. And as you know also know that we actually expect that we will have improvements during the — momentum during the year. So at this point, we are just expecting this to look better. And especially since we have a lot of customers that bought one or maybe two Xs have done validation work on that. And we are starting to see these multiple orders coming in now up to 10 instruments at a time. So I think you will see that momentum go through the year also.

Joydeep Goswami: But Dave, this is not based on some magic new budget thing, right? We as — just to reiterate, we have expected to see the macroeconomic conditions continue as they are right now.

Operator: Your next question comes from the line of Subha Nambi with Guggenheim.