For those of you who are familiar with Foundation ICEas it exists today, the overall interface here will be familiar but the look and feel has been completely revamped. In the standards here, you will see a table that contains all of the patients for which foundation testing has been ordered. For patients who have reports already resulted, you see their name in blue and that links directly to the patient’s report. The diagnosis for each of those patients is listed along with now all of the genomic findings pulled right up under this work list. This is a new feature of ICE 2 that allows users at a glance to see the genomic distribution and see how those genomic findings are distributed across subsets of their patients.
If a user is a super user, for example, office manager or a nurse, they can see multiple physicians, potentially of multiple facilities, all in one interface. The final column shows the report status for a report that has already been resulted, the dateof that report is listed. For a report that is still in progress, for a sample that is still being processing, those results are shown in their stage of processing for the user. For example, that is not yet received by the lab, it is listed as pending specimen and that is an opportunity for that physician potentially to reach out to their pathology lab and make sure that that sample has been sent. A sample has been received and is already processing, it is listed either at sequencing, orif it is done, sequencing is analyzing results. Again, to allow the physicians to be as informed as possible about where their sample is in the process.
We have also significantly enhanced our search capability. With this one search box, a user can search their entire work list by patient name if they’re looking for a particular patient or record number and now, by gene and diagnosis. A physician or a user or an administrator who wants to find, let us say, all of the patients who have been found to have ALK mutations, then simply type ALK into this box and in real time, their entire work was just filtered. This is the feature that we have heard that is extremely helpful for physicians who wants to identify it, say, in a patient before with a particular combination of diagnosis and genomic finding or perhaps for clinical research coordinator who wants to see if there is enough patients who match a particular genomic profile to recruit a clinical trials to their institution.
Next, I’ll show you a detailed view of a patient report. The patient report again has been visually revamped to optimize for the physician and the user’s interaction. All of the components of the report that users are familiar with are still present, the patient demographics, the genomic findings, the associated therapies and the clinical trials. We have now built the interface so the users can get an overview of all of these findings at once and dive in to the features and get more details as needed.
We have pulled out all the genomic findings upfront withan individual brick for each gene and alteration has been identified. We have also listed the number of therapies that are associated with that finding. By clicking on one of these bricks, the user is able to go in and see details about why that gene is associated in this tumor type and what the implications are.
Next, we have called out all of the therapies that a user may consider based on the genomic findings. We have broken this down by therapies that are FDA approved in this tumor type and FDA approved therapies in other tumor types. Each of those therapies can be expanded in place to show the target and rationale for including that therapy in this report. Any references that maybe applicable which the user can then click through directly to PubMed and any clinical trials that are associated with that that a user might want to enroll their patient in.
