Exact Sciences Corp (EXAS): Billionaire David E. Shaw’s D E Shaw Ups Its Stake

Page 4 of 6 – SEC Filing

Item 1.
	(a)	Name of Issuer
		Exact Sciences Corporation
	(b)	Address of Issuer’s Principal Executive Offices
		441 Charmany Drive Madison, WI 53719
Item 2.
	(a)	Name of Person Filing
		D. E. Shaw & Co., L.P. David E. Shaw
	(b)	Address of Principal Business Office or, if none, Residence
		The business address for each reporting person is: 1166 Avenue of the Americas, 9th Floor New York, NY 10036
	(c)	Citizenship
		D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware. David E. Shaw is a citizen of the United States of America.
	(d)	Title of Class of Securities
		Common stock, par value $0.01
	(e)	CUSIP Number
		30063P105
Item 3.		If this statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) or (c), check whether the person filing is a:
Not Applicable
Item 4.		Ownership

As of August 15, 2016:

(a)

Amount beneficially owned:

	D. E. Shaw & Co., L.P.:	5,440,212 shares This is composed of (i) 3,306,923 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 2,069,789 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 63,500 shares under the management of D. E. Shaw Investment Management, L.L.C.
	David E. Shaw:	5,440,212 shares This is composed of (i) 3,306,923 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 2,069,789 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 63,500 shares under the management of D. E. Shaw Investment Management, L.L.C.

(b)

Percent of class:

	D. E. Shaw & Co., L.P.:	5.0%
	David E. Shaw:	5.0%