Dan Skovronsky : Yes. Sure. As I was just saying I mean obesity is clearly a chronic often lifetime disease. And for such diseases patients often need to take therapy for chronically — potentially life of the disease here. A lot of times in medicine that doesn’t happen of course, people come off of therapies, because either the therapy is working, and they think they don’t need anymore or there’s a benefit they can’t see. I’m not sure either of those are the case for a drug like tirzepatide. People clearly can observe the benefits that the drug is having on their health. And perhaps unfortunately, but not different really than any other drug that we have for any other disease. When you stop taking the drug, it’s likely that it can no longer work, and patients may see that as well.
So I think those factors will combine to have a pretty long duration of therapy. We have to wait and see in the marketplace maybe Mike has some early signals from patients, but still pretty early on. Anything there, Mike?
Mike Mason : Yes, no hard data yet on that. But qualitatively what we hear is what patients who’ve used Mounjaro, what they like and what they realize once they start using it is that it really does reduce the appetite, and they enjoy the benefits of reducing appetite. It helps them lose their — lose weight and stop being as consumed as much during today about 80%. And we do know that when — what we heard from our investigators and our studies is that when people stop taking Mounjaro that their appetite goes back to the level, it was before. So that’s something very noticeable something that a patient values from taking the therapy and then when they stop the therapy, they then see this reversed. And so we do believe that people are going to stop, and see if they can lose weight if they can great.
But I do think that they’re going to see a very powerful signal very quickly to reinforce going back on the product. So I do think that will help reinforce the chronic use of tirzepatide for type two diabetes, and eventually for obesity if we get approved. The question on Trulicity. Mounjaro if you look at Mounjaro’s use right now and compare it to how many customers are using that versus Trulicity at this time, it’s a lot broader population than we saw with Trulicity is because the market is a lot bigger a lot more people are riding the treatment. If you compare Mounjaro to the number of Trulicity riders today there are more people riding Trulicity just, because it’s been on the market longer. They’ve gone through the adoption curve and Trulicity has better access, access and especially in Medicaid that drives additional prescribers to use that.
So overall I’d say the Mounjaro is within the universe of the doctors who write Trulicity at this point.
Joe Fletcher : Thank you, Geoff for the question. Lois, next question.
Operator: The next question is from Tim Anderson from Wolfe Research. Please go ahead.
Tim Anderson : Thank you. I have a question on donanemab. I’m wondering if Lilly would agree that there is highly likely going to be higher area E and area H rates with your drug versus lecanemab when TRAILBLAZER-ALZ 2 reports out. The prior data would certainly suggest that. If so, relative to lecanemab, doesn’t that create a potential risk benefit conundrum for FDA assuming efficacy comes in around the same levels. I guess the bottom line here is there a regulatory concern to contemplate maybe this is why FDA issued the CRL they want to see the full results from your second study. You don’t just want to capture a few more patients to bring that total to 100, or am I being too bearish here? Thank you.
