But we believe that long-term, we are positioned for a first-line placement in treatment of ulcerative colitis. And yes, so the outlook for mirikizumab. It’s exciting from a competitive landscape perspective, we don’t have bad to have data. But if we compare the data we have seen so far, we believe that mirikizumab compares very favorable both versus what’s currently in the marketplace as well as what’s in the pipeline with other companies across JAK inhibitors S1Ps and other IL-23s as well. So exciting to launch mirikizumab the first half of this year. When it comes to lebri, I think actually, we are uniquely positioned to really upgrade the expected outcomes of patients with atopic dermatitis. We have here an asset that is actually targeting the most relevant cytokine when it comes to treating atopic dermatitis, IL-13 and it does that with a high binding affinity, high potency and a slow off rate.
And I think that probably explains the data that we have seen so far. We’re extremely pleased with the Phase III data, and we sold more than 80% of patients achieving skin clearance at Week 16, maintaining that at Week 52, but also very importantly, statistical and clinically meaningful improvements across both each, which is probably the most disturbing factor for patients with atopic dermatitis, sleep and quality of life. And we saw similar results across both the Q2W and Q4W formulation. We actually believe that lebrikizumab has the potential to become a first-line biologic. It’s important to have in mind that we announced the submission at the Q3 earnings call, and we expect that traditional regulatory pathway. Yes, we will not launch until most likely Q4 of 2023.
But a lot of excitement from both health care providers and tier community as well on the payers to get leverage to the market.
Joe Fletcher: Thank you, Patrick. Dave, to wrap up?
Dave Ricks: Great. I think that’s the last question. I appreciate the questions across the portfolio. And we appreciate your participation in today’s earnings call and your interest in our company. 2022 was another productive year for the company, and we generated strong financial results and delivered important pipeline progress in each of our core therapeutic areas on behalf of the patients we serve. We aim to continue our momentum in 2023 and execute on the meaningful launch and pipeline opportunities that we have ahead of us. So thanks for dialing in, and please follow up with IR, if you have questions that we didn’t get to you today. Have a great day.
Operator: Thank you. And ladies and gentlemen, this does conclude our conference for today. And this conference will be made available for replay beginning at 1:00 today, running through February 9 at midnight, and you may access the AT&T replay system at any time by dialing 866-207-1041 and entering the access code 4283950. International dialers can call 402-970-0847. Again those numbers are 1866-207-1041 and 402-970-0847 with the access code 4283950. And that does conclude our conference for today. Thank you for your participation and for using AT&T Event Conferencing. You may now disconnect.
