Matt McGrew: Yes. No, I mean I think if you are going through the full year, the math is what it is at around 30% adjusted OP margins, I think sort of that takes care of itself. As far as what we are going to look like as we sort of get to the other side of this. I mean I talked a little bit about Cepheid kind of was 20% to 25% pre-pandemic, peaked up at 45% and 35% to 40%. I mean I think if you sort of use that frame plus what we have in diagnostics, that sort of gets you where we think roughly the margin profile will be. Biotech is probably the other one after we get through some of these costs. The same math there was biotech was, call it, high 30s prior to the pandemic. Again, it peaked at around, call it, 45% and change.
And after we sort of get through what I think we are going to do there, they are probably going to be more like low-40s. So, again better than they were pre-pandemic given the fact that they are a bigger business. But those two pieces, I think you can slide into what ‘24 might look like. And then life sciences, that should be kind of plus or minus where we have been here. That has not been a margin that’s moved around quite a bit. A little bit of COVID stuff as we had in ‘22 and ‘21, but I think you can kind of get a sense of what the margins are there. So, maybe it’s just a high-level framework, you are probably high-30s, low-40s with Cepheid, you can kind of assume some other stuff for the diagnostics, biotech, probably low-40s than what we are seeing in LS.
But we will obviously sort of come back to that later, still pretty early in ‘23, but just to give you a very high level view.
Dan Brennan: Great. Thanks Matt. Thanks guys.
Rainer Blair: Thanks Dan.
Operator: And we will take our next question from Jack Meehan with Nephron. Please go ahead.
Rainer Blair: Good morning Jack.
Jack Meehan: Thanks. Good morning. Another question on bioprocessing. Can you share what was your total order rate in the quarter? Is there any color you can just share around how the quarter played out? Have things weakened throughout the quarter. Just curious about how things are trending.
Rainer Blair: Sure, Jack. So, once again, first quarter, our orders were down modestly sequentially. So, relative to the fourth quarter, down modestly. But year-over-year, they declined 20%, okay. And so what we have been seeing is the inventory burn down that we have been talking about Matt and myself, is occurring, and we see that in our order book here for the first quarter. And then again, we have laid out why we believe that the current activity level supports sort of a similar progression of the quarters here throughout the year as we had in the first quarter.
Jack Meehan: Great. Thank you. And then just as a follow-up, I was curious what impact, if any, did you see from the banking crisis, which took place in the quarter. I understand you probably didn’t have any direct exposure to that, but how are your customers reacting sort of across the business?
Rainer Blair: Right. So, direct exposure was not material in any sense of the word. As it relates to the impact on our businesses, particularly in bioprocessing, to a much lesser extent in life sciences, we do think that, that provides that additional inflection point here in the first quarter for liquidity tightening up and that prioritization that we are seeing here in the emerging biotech segment, call it emerging biotech, and once again, those companies working on earlier stage projects. So, that’s where we have seen a more pronounced conservation of cash and that plays out in OpEx, CapEx and you can – and we talked about how that played out with mid-teens contraction as opposed to sort of a mid-teens growth versus prior periods.
Jack Meehan: Thank you, Rainer.
Rainer Blair: Thanks Jack.
Operator: And we will take our final question from Rachel Vatnsdal with JPMorgan. Please go ahead.
Rainer Blair: Good morning Rachel.
Rachel Vatnsdal: Great. Good morning. Thank you for taking the questions you guys. And so I appreciate all the comments that you have given on emerging biotech softness in bioprocessing with that customer set really down mid-teens in 1Q. So first, just a clarifying question. Did you say that you expect that emerging biotech to remain at mid-teen declines for the year? And then kind of shifting more longer term, can you talk about your assumptions around when you expect emerging biotech to return to growth? And at what point can this funding issue really pressure the long-term growth outlook for the bioprocessing market?
Rainer Blair: So, just to confirm on the topic of emerging biotech, our assumption is and our guide reflects that the activity level in emerging biotech stays for the remainder of the year as it played out in the first quarter. So, we are not assuming any change there including that it doesn’t get significantly worse. Now, as it relates to how that segment progresses here, that’s from today’s point of view, hard to predict. We need to see where capital markets go, liquidity availability and yes, a stabilization and return to some degree of normality in the banking sector. But for the visibility that we have today, we are not expecting an improvement in that segment for the remainder of the year.
Rachel Vatnsdal: Got it. And then maybe a few questions on China here. So, one of your peers recently signed China bioprocessing, I think you also mentioned that in one of your answers to earlier question. So, can you talk about how did bioprocessing performed during 1Q in China? And can you just give us some context of how big China is for bioprocessing for Danaher? Looking forward, how are those orders trending within China, specifically around some of the localized manufacturers. And then last question, just stepping back, you previously had guided to low-single digit growth for China for the year. 1Q was well above expectations. So, what’s the total co-outlook for China? Thanks.
Rainer Blair: Well, as it relates to bioprocessing in China, we have had a very good and strong business there in China for years. And it helped quite significantly in China in order to build the capacity for vaccines and for other biologics. And what we see today, much like we have seen in the U.S. is that the Emerging Biotech segment, which is an important part of China’s efforts to build a local biopharma industry is also impacted by capital constraints. So, we have seen that play out in China as well. And in fact, that’s what is the primary impact on our China numbers here. In the first quarter, which on the whole were better than expected, primarily because of the patient volumes and the diagnostic businesses being stronger.
Now, as it relates to the full year in China, we expect our full year in China to be up low-single digits for Danaher overall based on the market recovery, exiting COVID as well as, if you will, a normalization of the activity level in bioprocessing.
