D. E. Shaw & Co Raises Exposure to Biocryst Pharmaceuticals Inc (BCRX)

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Page 6 of 6 SEC Filing

SIGNATURE

After reasonable inquiry and to the best of their knowledge
and belief, the undersigned certify that the information set forth in this statement is true, complete and correct. A Power of
Attorney, dated December 16, 2014, granted by David E. Shaw in favor of Nathan Thomas, is attached hereto.

Dated: March 14, 2016

D. E. Shaw & Co., L.P.
By: /s/ Nathan Thomas
Nathan Thomas
Chief Compliance Officer
David E. Shaw
By: /s/ Nathan Thomas
Nathan Thomas
Attorney-in-Fact for David E. Shaw

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