Bristol-Myers Squibb Company (NYSE:BMY) Q4 2022 Earnings Call Transcript

So more to follow on that in appropriate time to come. But really pleased with that. And the last question that you had on the additional fibrosis programs, we’re looking at LPA1 from two perspectives right now. One is the IPF program and the other one is the progressive or pulmonary fibrosis. But that Phase II data is going to be reading out later this year. So we’re looking at those two things for now.

Timothy Power : Samit, I think we’re running short on time. Maybe we can go to our last question please, Dennis.

Operator: Today’s final question will come from the line of Colin Bristow with UBS.

Colin Bristow : Maybe just a couple of very quick pipeline questions. I see you have another TYK2 inhibitor in Phase I. Could you just give us any color on the matter and how you’d anticipate it differentiating versus the TYK2? And then just another one on 207, you recently terminated Phase 1 development in non-small cell. This is one of our anti-TIGIT. I think you cited safety issues. I was just wondering if you could specifically say what these issues were?

Samit Hirawat : Sure. Thank you. In terms of your first question around the Phase I that is ongoing with the next TYK2 inhibitor. In general, we always have one or two programs that we look at in terms of having the next generation of molecules in development. And so this is just phases of development of general pipeline that we have additional TYK2 inhibitor. We also have a CNS penetrant TYK2 inhibitor that is in Phase I. So there is nothing special at this time to talk about. But certainly, as the data arises, as the data evolves, we will be able to share those data in the future. For the TIGIT program, remember, this is a trial that was being conducted in patients with non-small cell lung cancer looking at a combination with nivolumab and ipilimumab.

And what we have seen thus far, I’m not going into the specifics because those data will be presented at some future conference, but we do see that there is a toxicity that is observed when combined with dual I-O therapy for this particular TGT inhibitor. And so more data to come as we get more insights and more specifics on that and then the presentation will be done. But because of those safety reasons, we have decided to terminate this particular trial at this time.

Giovanni Caforio : Thank you, Samit, and thanks to all of you for your participation. As you’ve seen, it’s an exciting time for the company. We have another important year ahead, lots of things to talk about, but we know it’s a very busy morning for all of you, so we’re going to end the call here. And as always, please reach out to our team if you have any additional questions. So thanks, everyone, and have a great day. Thank you.

Operator: This does conclude the Bristol-Myers Squibb’s Fourth Quarter 2022 Earnings Conference Call. Thank you for your participation. You may now disconnect.