Stephen Scala : We noted that Bristol initiated a milvexian SSP Phase III trial with primary completion in November 2026 and that additional Phase IIIs will be started in the first half of this year. But Bayer studies are expected to read out a full year earlier. Is this consistent with your perception that Bristol is a year behind Bayer? I should add that you are not first with Eliquis and ended up dominating, but let me let you answer the question.
Samit Hirawat : Thank you, Steve. Samit here. Thank you for the question. Look, we planned the studies, and we put a timeline with those studies in terms of the enrollment. And then of course, these are event-driven trials. So we’ll have to wait for the events to happen before we read out and report the results. So we have to take all of those into account, but of course, the clinical trials we can impact them by looking at what the enrollment rates are and how these trials are involved. So I think what you see on trials.gov is our guesstimate of when the trials are going to be reading out it is that we might be leading out earlier. It is possible our competitors will be reading out later. But these are early days, and we’ll update you as the trial progresses if the time lines do shift.
Operator: The next question is from the line of Tim Anderson with Wolfe Research.
Timothy Anderson : A few questions back on Sotyktu. Can you just quantify where you are on market access in ’22 in terms of number of lives covered? And where you do have access, are there any step that is requiring Otezla first? And then on your Bridge program, will that last all the way through ’23? Or will you begin to phase it out before year-end?
Christopher Boerner : Thanks for the question. So with respect to market access, we think we have about 10% of patients who are in plans that have open or preferred access. And obviously, that’s going to continue to increase as we continue to engage with payers. And as we said, our base case for a much more favorable access position at large across the major PBMs is for 2024, but we’re doing everything we can to accelerate that. As for the Bridge programs, Bridge programs are typical in this market, and I think we would typically think about keeping those Bridge programs open until we find that we are in a position where we’ve got the volume to negotiate a much faster access or more favorable access with the big PBMs. The nice thing that we’re seeing, Tim, with Sotyktu is that the vast majority of patients are going into our hub.
What that enables us to do is monitor the status of those patients with respect to formulary positioning. And so even if that Bridge program is open, we have the ability to transition those patients to commercial drug, the moment we certify that their plans are able to take them on commercial drug. And so it’s a more dynamic process than might be indicated just in the discussions that we’ve had. In fact, we have the ability to look at this on a more real-time basis. But we do anticipate that those Bridge programs will remain open certainly as we get into 2024.
Operator: The next question is from the line of Evan Seigerman with BMO Capital Markets.
Evan Seigerman : On Abecma, you went from kind of struggling to meet patient demand in early 2022 to now expanding into earlier lines of therapy. Now how should we think about bridging this gap, really I’m talking about expanding capacity and when we could potentially see more slots come online for both your cell therapies?
