Biocryst Pharmaceuticals Inc (BCRX): Billionaire David E. Shaw’s Fund Increases Stake

Page 4 of 6 – SEC Filing
Item 1.
(a) Name of Issuer
BioCryst Pharmaceuticals, Inc.

(b)

Address of Issuer’s Principal Executive Offices

4505 Emperor Blvd., Suite 200

Durham, NC 27703

Item 2.
(a) Name of Person Filing

D. E. Shaw & Co., L.P.

David E. Shaw

(b) Address of Principal Business Office or, if none, Residence

The business address for each reporting person is:

1166 Avenue of the Americas, 9th Floor

New York, NY 10036

(c)

Citizenship

D. E. Shaw & Co., L.P. is a limited partnership organized
under the laws of the state of Delaware.

David E. Shaw is a citizen of the United States of America.

(d) Title of Class of Securities
Common stock, par value $0.01
(e) CUSIP Number
09058V103

Item 3.

If this statement is filed pursuant to Rule
13d-1(b) or 13d-2(b) or (c), check whether the person filing is a:

Not Applicable

Item 4. Ownership

As of August 11, 2016:

(a) Amount beneficially owned:

D. E. Shaw & Co., L.P.:

3,740,239 shares

This is composed of (i) 1,912,534 shares in the name
of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,426,384 shares in the name of D. E. Shaw Oculus Portfolios,
L.L.C., and (iii) 401,321 shares under the management of D. E. Shaw Investment Management, L.L.C.

David E. Shaw:

3,740,239 shares

This is composed of (i) 1,912,534 shares in the name
of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,426,384 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii)
401,321 shares under the management of D. E. Shaw Investment Management, L.L.C.

(b) Percent of class:
D. E. Shaw & Co., L.P.: 5.1%
David E. Shaw: 5.1%

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