Page 8 of 9 – SEC Filing Name Date Number of Shares Transaction Price/Share Footnotes 667, L.P. 8/12/2016 465,439 Sale 5.0000 Baker Brothers Life Sciences, L.P. 8/12/2016 2,834,561 Sale 5.0000 667, L.P. 8/12/2016 48,744 Sale 5.2541 1 Baker Brothers Life Sciences, L.P. 8/12/2016 296,856 Sale 5.2541 1 667, L.P. 8/15/2016 56,417 Sale 4.8276 2 Baker Brothers Life Sciences, L.P. 8/15/2016 343,583 Sale 4.8276 2 667, L.P. 8/16/2016 140 Sale 4.2887 3 Baker Brothers Life Sciences, L.P. 8/16/2016 850 Sale 4.2887 3
(1) The reported price is a weighted average price. These shares were traded in multiple transactions
at a prices ranging from $5.04 to $5.47. The Reporting Persons undertake to provide the Issuer, any security holder of the Issuer,
or the staff of the Securities and Exchange Commission (the “Staff”), upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(2) The reported price is a weighted average price. These shares were
traded in multiple transactions at prices ranging from $4.70 to $5.12. The Reporting Persons undertake to provide the Issuer, any
security holder of the Issuer, or the Staff, upon request, full information regarding the number of shares traded at each separate
price within the ranges set forth in this footnote.
(3) The reported price is a weighted average price. These shares were traded in multiple transactions
at prices ranging from $4.20 to $4.30. The Reporting Persons undertake to provide the Issuer, any security holder of the Issuer,
or the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set
forth in this footnote.
(d) Certain securities of the Issuer
are held directly by 667, a limited partnership the sole general partner of which is Baker Biotech Capital, L.P., a limited partnership
the sole general partner of which is Baker Biotech Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members
of Baker Biotech Capital (GP), LLC.
Certain securities of the Issuer are held directly by Life Sciences,
a limited partnership the sole general partner of which is Baker Brothers Life Sciences Capital, L.P., a limited partnership the
sole general partner of which is Baker Brothers Life Sciences Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling
members of Baker Brothers Life Sciences Capital (GP), LLC.
(e) Not applicable.
| Name | Date | Number of Shares | Transaction | Price/Share | Footnotes | |||||||||||||||
| 667, L.P. | 8/12/2016 | 465,439 | Sale | 5.0000 | ||||||||||||||||
| Baker Brothers Life Sciences, L.P. | 8/12/2016 | 2,834,561 | Sale | 5.0000 | ||||||||||||||||
| 667, L.P. | 8/12/2016 | 48,744 | Sale | 5.2541 | 1 | |||||||||||||||
| Baker Brothers Life Sciences, L.P. | 8/12/2016 | 296,856 | Sale | 5.2541 | 1 | |||||||||||||||
| 667, L.P. | 8/15/2016 | 56,417 | Sale | 4.8276 | 2 | |||||||||||||||
| Baker Brothers Life Sciences, L.P. | 8/15/2016 | 343,583 | Sale | 4.8276 | 2 | |||||||||||||||
| 667, L.P. | 8/16/2016 | 140 | Sale | 4.2887 | 3 | |||||||||||||||
| Baker Brothers Life Sciences, L.P. | 8/16/2016 | 850 | Sale | 4.2887 | 3 | |||||||||||||||
(1) The reported price is a weighted average price. These shares were traded in multiple transactions
at a prices ranging from $5.04 to $5.47. The Reporting Persons undertake to provide the Issuer, any security holder of the Issuer,
or the staff of the Securities and Exchange Commission (the “Staff”), upon request, full information regarding the
number of shares traded at each separate price within the ranges set forth in this footnote.
(2) The reported price is a weighted average price. These shares were
traded in multiple transactions at prices ranging from $4.70 to $5.12. The Reporting Persons undertake to provide the Issuer, any
security holder of the Issuer, or the Staff, upon request, full information regarding the number of shares traded at each separate
price within the ranges set forth in this footnote.
(3) The reported price is a weighted average price. These shares were traded in multiple transactions
at prices ranging from $4.20 to $4.30. The Reporting Persons undertake to provide the Issuer, any security holder of the Issuer,
or the Staff, upon request, full information regarding the number of shares traded at each separate price within the ranges set
forth in this footnote.
(d) Certain securities of the Issuer
are held directly by 667, a limited partnership the sole general partner of which is Baker Biotech Capital, L.P., a limited partnership
the sole general partner of which is Baker Biotech Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members
of Baker Biotech Capital (GP), LLC.
Certain securities of the Issuer are held directly by Life Sciences,
a limited partnership the sole general partner of which is Baker Brothers Life Sciences Capital, L.P., a limited partnership the
sole general partner of which is Baker Brothers Life Sciences Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling
members of Baker Brothers Life Sciences Capital (GP), LLC.
(e) Not applicable.
