And our goal of course, is to have the information required to go back into the FDA for ROR2 and get a picture of that. We also should have, we’re going to update in May, but we’re hoping to have a much better picture of what our recruitment rate is in the head and neck. And then of course, we’ll hopefully get a snapshot of what’s happening on the circulating tumor cell assay and melanoma.
Brian Cheng: Great, thank you. Thanks for taking my question.
Jay Short: By the way, Brian, just one thing. We have to submitted to one of the upcoming conferences. We haven’t got feedback yet from the meeting, but we intend to present the exposure response analysis data as soon as possible so people can get a flavor and get under the hood on these other more frequent, dose intense regimens.
Brian Cheng: For the ROR2.
Jay Short: For ROR2 and AXL.
Operator: Our next question comes from the line of Kelly Shi with Jefferies.
Kelly Shi: Thank you for taking my questions. My first question is about AXL program in UPS. You mentioned at a more frequent dosing, 3Q4W.The DLT window has been cleared for first six patients in LMS subtype. I’m curious, would you share the efficacy outcome for the six patients in near term and also for the Phase 2, part 2, you’re going to evaluate two different dosing, 3Q4W, and a 2Q3W in the first 40 patients. I’m curious, does FDA require another meeting after these 40 patients and talking about efficacy and safety for the decision on the dosing regimen for the next 40 patients in part 2? Thank you.
Brian Cheng: Thank you, Charlie. I’m going to let Philly help me on this one a little bit, but I’m going to start by saying you did get snapshot in January of the first scan of one of the patients at the 3Q4W when we reported out in Leiomyosarcoma that we saw 29.6% tumor reduction on first scan. So that was the first patient. But we are moving toward 10 to 15 patients, and we believe that we’re just going to wait until we get those because we think they’ll come in in a timely fashion for second half of this year. But obviously, we’re very hopeful that we’re going to see some interesting data coming out of that. But Philly, maybe you can add to this answer.
Philippe Martin: Yes. With regard to the timelines for the 3Q4W LMS score, we’ll wait until we have approximately 15 patient worth of data, which is expected in second half of this year, as Jay mentioned. And then your question about FDA requirement. FDA does not require us to meet with them after the first 40 patients, but that’s certainly our intention is to meet with them and to make sure that we align on the dose we are selecting for the next 40 patients to be enrolled, because that will be the dose we ask to be registered. And so we’ll be planning on having a meeting with the agency once we have the first 40 patient enrolled in UPS.
Kelly Shi: Okay, thank you very much. I also have a follow up, if I may. So for the UPS Phase 2, do you plan to provide any data updating this year? And also at the moment, would you be able to share the information regarding how many sites have been activated?
Jay Short: Philip, if you €“
Philippe Martin: Yes, so the data we just provided in this update is the data on all the UPS patient we’ve treated to date. The median PFS has evolved from the last time we reported the data. We are now at approximately 11 months and which I think the last time we reported date we were at about 6.8 months, something like that. So the PFS is evolving positively. Some patients are still on treatment, so that might continue to evolve. But I think you got a very basically, the data we are reporting today is very close to the final data in UPS. What was your other question? I’m sorry.
